The role of oral methotrexate as a steroid sparing agent in refractory eosinophilic asthma. by Bilocca, D, Hargadon, B, Pavord, I, Green, R, Brightling, C, Bradding, P, Wardlaw, A, Martin, N, Murphy, A, Siddiqui, S

“…The use of oral methotrexate for refractory eosinophilic asthma in a tertiary asthma referral centre, Glenfield Hospital, Leicester, was evaluated between January 2006 and December 2014. …”

Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. by Shaw, D, Berry, M, Hargadon, B, McKenna, S, Shelley, M, Green, R, Brightling, C, Wardlaw, A, Pavord, I

“…Multivariate analysis was performed on data collected from 1,197 consecutive patients with asthma seen at the respiratory outpatient clinic at Glenfield Hospital between 1997 and 2004. Relationships between induced sputum total neutrophil and differential eosinophil cell counts, and prebronchodilator and postbronchodilator lung function were examined. …”

Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlle... by Gonem, S, Berair, R, Singapuri, A, Hartley, R, Laurencin, M, Bacher, G, Holzhauer, B, Bourne, M, Mistry, V, Pavord, I, Mansur, A, Wardlaw, A, Siddiqui, S, Kay, R, Brightling, C

“…We hypothesised that fevipiprant (QAW039), an antagonist of prostaglandin D2 receptor 2, might reduce eosinophilic airway inflammation in patients with moderate-to-severe eosinophilic asthma.We performed a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial at Glenfield Hospital (Leicester, UK). We recruited patients with persistent, moderate-to-severe asthma and an elevated sputum eosinophil count (≥2%). …”

Randomised controlled trial and parallel economic evaluation of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CE... by Peek, G, Elbourne, D, Mugford, M, Tiruvoipati, R, Wilson, A, Allen, E, Clemens, F, Firmin, R, Hardy, P, Hibbert, C, Jones, N, Killer, H, Thalanany, M, Truesdale, A

“…SETTING: The ECMO centre at Glenfield Hospital, Leicester, and approved conventional treatment centres and referring hospitals throughout the UK. …”