Iron overload in mild sideroblastic anaemias. by Peto, T, Pippard, M, Weatherall, D

“…Life-threatening iron overload may occur without severe anaemia in patients with sideroblastic disorders. …”

IRON OVERLOAD IN NON-TRANSFUSED SIDEROBLASTIC ANEMIAS by Pippard, M, Peto, T, Weatherall, D

Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes. by Roy, N, Myerson, S, Schuh, A, Bignell, P, Patel, R, Wainscoat, J, McGowan, S, Marchi, E, Atoyebi, W, Littlewood, T, Chacko, J, Vyas, P, Killick, S

“…Transfusion-dependent myelodysplastic (MDS) patients are prone to iron overload. We evaluated 43 transfused MDS patients with T2* magnetic resonance imaging scans. 81% had liver and 16·8% cardiac iron overload. …”

COMPREHENSIVE GENETIC TESTING IS REQUIRED FOR PATIENTS WITH UNEXPLAINED IRON OVERLOAD by Bignell, P, Merryweather-Clarke, A, Lok, C, Schuh, A, Robson, K

Porphyria cutanea tarda and beta-thalassaemia minor with iron overload. by Chapman, R

Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. by Chapman, R, Morgan, M, Laulicht, M, Hoffbrand, A, Sherlock, S

“…However, in alcoholics with significant liver disease serum ferritin concentrations did not reflect iron stores accurately, although with normal values iron overload is unlikely. Serum iron concentration and percentage saturation of total iron-binding capacity were of little value in assessing iron status in either alcoholics or patients with hemochromatosis. …”

Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload. by Sado, D, Maestrini, V, Piechnik, S, Banypersad, S, White, S, Flett, A, Robson, MD, Neubauer, S, Ariti, C, Arai, A, Kellman, P, Yamamura, J, Schoennagel, B, Shah, F, Davis, B, Trompeter, S, Walker, M, Porter, J, Moon, J

“…PURPOSE: To explore the use and reproducibility of magnetic resonance-derived myocardial T1 mapping in patients with iron overload. MATERIALS AND METHODS: The research received ethics committee approval and all patients provided written informed consent. …”

Hemochromatosis gene (HFE) mutations in South East Asia: a potential for iron overload. by Pointon, J, Viprakasit, V, Miles, K, Livesey, K, Steiner, M, O'Riordan, S, Hien, T, Merryweather-Clarke, A, Robson, K

“…We suggest that the presence of the IVS5+1 G-->A and H63D mutations should be considered when investigating iron overload in Vietnamese patients and those of mixed origin as co-inheritance of both mutations is likely to be a risk factor for iron overload.…”

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload. by Townsend, A, Drakesmith, H

“…Hereditary haemochromatosis is an iron overloading disorder caused by common mutations in the HFE gene. …”

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload by Townsend, A, Drakesmith, H

The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload by Mohammad, G, Matakidou, A, Robbins, PA, Lakhal-Littleton, S

“…Under conditions of excess iron availability, male and female mice harboring this allele had milder kidney iron overload, but greater systemic iron overload relative to controls. …”

Erratum: Role of HFE in iron metabolism, hereditary haemochomatosis, anaemia of chronic disease and secondary iron overload (Lancet (March 2) (786)) by Townsend, A, Drakesmith, H

Role of HFE in iron metabolism, hereditary haemochomatosis, anaemia of chronic disease, and secondary iron overload (vol 359, pg 786, 2002) by Townsend, A, Drakesmith, H

THE USE OF NEXT-GENERATION SEQUENCING TO SCREEN FOR MUTATIONS IN 16 GENES INVOLVED IN IRON HOMEOSTASIS AS AN AID TO GENETIC DIAGNOSIS FOR PATIENTS WITH IRON OVERLOAD OR IRON DEFICIENCY by Bignell, P, Burns, A, Schuh, A, Robson, K

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload by Schwartz, A, Das, N, Ramakrishnan, S, Jain, C, Jurkovic, M, Wu, J, Nemeth, E, Lakhal-Littleton, S, Colacino, J, Shah, Y

“…This pathway is perturbed in diseases that cause iron overload. Additionally, intestinal HIF-2α is essential for the local absorptive response to systemic iron deficiency and iron overload. …”

Hepatic hepcidin/intestinal HIF-2a axis maintains iron absorption during iron deficiency and overload by Schwartz, A, Das, N, Ramakrishnan, S, Jain, C, Jurkovic, M, Wu, J, Nemeth, E, Lakhal-Littleton, S, Colacino, J, Shah, Y

“…This pathway is perturbed in diseases that cause iron overload. Additionally, intestinal HIF-2a is essential for the local absorptive response to systemic iron deficiency and iron overload. …”

Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species. by Arezes, J, Costa, M, Vieira, I, Dias, V, Kong, XL, Fernandes, R, Vos, M, Carlsson, A, Rikers, Y, Porto, G, Rangel, M, Hider, RC, Pinto, JP

“…NTBI is responsible for the toxicity associated with iron-overload pathologies but the mechanisms leading to NTBI uptake are not fully understood. …”

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project. by Lehmann, D, Schuur, M, Warden, DR, Hammond, N, Belbin, O, Kölsch, H, Lehmann, MG, Wilcock, G, Brown, K, Kehoe, P, Morris, C, Barker, R, Coto, E, Alvarez, V, Deloukas, P, Mateo, I, Gwilliam, R, Combarros, O, Arias-Vásquez, A, Aulchenko, Y, Ikram, M, Breteler, M, van Duijn, C, Oulhaj, A, Heun, R

“…Iron overload may contribute to the risk of Alzheimer's disease (AD). …”

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia by Fortin, P, Fisher, S, Madgwick, K, Trivella, M, Hopewell, S, Doree, C, Estcourt, L

“…Iron chelation therapy is used to prevent or treat iron overload, but it can be a demanding regimen, and have unwanted side effects. …”

Transferrin and HFE genes interact in Alzheimer's disease risk: The Epistasis Project by Lehmann, D, Schuur, M, Warden, DR, Hammond, N, Belbin, O, Kölsch, H, Lehmann, MG, Wilcock, G, Brown, K, Kehoe, P, Morris, C, Barker, R, Coto, E, Alvarez, V, Deloukas, P, Mateo, I, Gwilliam, R, Combarros, O, Arias-Vásquez, A, Aulchenko, Y, Ikram, M, Breteler, M, van Duijn, C, Oulhaj, A, Heun, R

“…Iron overload may contribute to the risk of Alzheimer's disease (AD). …”