An Overview of Neisseria meningitidis by Hollingshead, S, Tang, C

“…Neisseria meningitidis (the meningococcus) is a member of the normal nasopharyngeal microbiome in healthy individuals, but can cause septicemia and meningitis in susceptible individuals. …”

Genealogical typing of Neisseria meningitidis. by Didelot, X, Urwin, R, Maiden, M, Falush, D

“…Here, we propose that different typing schemes should be compared on the basis of their power to infer clonal relationships and investigate the utility of sequence data for genealogical reconstruction by exploiting new statistical tools and data from 20 housekeeping loci for 93 isolates of the bacterial pathogen Neisseria meningitidis. Our analysis demonstrated that all but one of the hyperinvasive isolates established by multilocus enzyme electrophoresis and MLST were grouped into one of six genealogical lineages, each of which contained substantial variation. …”

Functional genomics of Neisseria meningitidis pathogenesis. by Sun, Y, Bakshi, S, Chalmers, R, Tang, C

“…The pathogenic bacterium Neisseria meningitidis is an important cause of septicemia and meningitis, especially in childhood. …”

Development of natural immunity to Neisseria meningitidis. by Pollard, A, Frasch, C

“…Although meningococcal disease is rare in industrialized nations, Neisseria meningitidis holds a prominent position amongst pediatric infections because of the dramatic clinical presentation of the disease, high mortality, epidemic potential and the recent disappearance of many other important infectious diseases in developed countries through improvements in public health and vaccination. …”

Correlates of protection against Neisseria Meningitidis. by Pollard, A

“…Over the past two decades, the leading cause of meningitis in childhood and the leading infectious cause of death in the UK has been Neisseria meningitidis. There is now the potential for broad control of this serious disease by vaccination. …”

Interactions between Neisseria meningitidis and the complement system. by Schneider, M, Exley, R, Ram, S, Sim, R, Tang, C

“…Meningococcal infection remains a worldwide health problem, and understanding the mechanisms by which Neisseria meningitidis evades host innate and acquired immunity is crucial. …”

THE INTERACTION BETWEEN FACTOR H AND NEISSERIA MENINGITIDIS by Tan, L, Schneider, M, Caesar, J, Kugelberg, E, Zhang, Q, Lea, S, Tang, C

Humoral immune responses to Neisseria meningitidis in children. by Pollard, A, Galassini, R, van der Voort, E, Booy, R, Langford, P, Nadel, S, Ison, C, Kroll, J, Poolman, J, Levin, M

“…Serum bactericidal activity was poor in children under 12 months of age despite recent infection with Neisseria meningitidis. The highest levels of bactericidal activity were seen in children over 10 years of age. …”

Temperature triggers immune evasion by Neisseria meningitidis. by Loh, E, Kugelberg, E, Tracy, A, Zhang, Q, Gollan, B, Ewles, H, Chalmers, R, Pelicic, V, Tang, C

“…Neisseria meningitidis has several strategies to evade complement-mediated killing, and these contribute to its ability to cause septicaemic disease and meningitis. …”

Temperature triggers immune evasion by Neisseria meningitidis by Loh, E, Kugelberg, E, Tracy, A, Zhang, Q, Gollan, B, Ewles, H, Chalmers, R, Pelicic, V, Tang, C

“…Neisseria meningitidis has several strategies to evade complement-mediated killing, and these contribute to its ability to cause septicaemic disease and meningitis. …”

Description and nomenclature of Neisseria meningitidis capsule locus by Harrison, O, Claus, H, Jiang, Y, Bennett, J, Bratcher, H, Jolley, K, Corton, C, Care, R, Poolman, J, Zollinger, W, Frasch, C, Stephens, D, Feavers, I, Frosch, M, Parkhill, J, Vogel, U, Quail, M, Bentley, S, Maiden, M

“… <p>Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. …”

Sequence conservation of pilus subunits in Neisseria meningitidis. by Cehovin, A, Winterbotham, M, Lucidarme, J, Borrow, R, Tang, C, Exley, R, Pelicic, V

“…The rapid onset and dramatic consequences of Neisseria meningitidis infections make the design of a broadly protective vaccine a priority for public health. …”

Cellular immune responses to Neisseria meningitidis in children. by Pollard, A, Galassini, R, Rouppe van der Voort, E, Hibberd, M, Booy, R, Langford, P, Nadel, S, Ison, C, Kroll, J, Poolman, J, Levin, M

“…There is an urgent need for effective vaccines against serogroup B Neisseria meningitidis. Current experimental vaccines based on the outer membrane proteins (OMPs) of this organism provide a measure of protection in older children but have been ineffective in infants. …”

Functional significance of factor H binding to Neisseria meningitidis. by Schneider, M, Exley, R, Chan, H, Feavers, I, Kang, Y, Sim, R, Tang, C

“…Neisseria meningitidis is an important cause of septicemia and meningitis. …”

Identification and characterization of genes required for competence in Neisseria meningitidis. by Sun, Y, Exley, R, Li, Y, Goulding, D, Tang, C

“…We have identified genes required for competence of Neisseria meningitidis, a naturally transformable human pathogen. …”

The spread of chloramphenicol-resistant Neisseria meningitidis in Southeast Asia by Batty, EM, Cusack, T-P, Thaipadungpanit, J, Watthanaworawit, W, Carrara, V, Sihalath, S, Hopkins, J, Soeng, S, Ling, C, Turner, P, Dance, DAB

“…<p><strong>Objectives:</strong><br /> Invasive disease caused by Neisseria meningitidis is a significant health concern globally, but our knowledge of the prevailing serogroups, antimicrobial susceptibility patterns, and genetics of N. meningitidis in Southeast Asia is limited. …”

Towards an improved serogroup B Neisseria meningitidis vaccine. by Perrett, K, Pollard, A

“…To date, however, the development of a universally safe, immunogenic and effective serogroup B Neisseria meningitidis vaccine has remained a challenge. This review details the many conventional vaccine strategies and the more recent genome-derived technological approaches being used in serogroup B vaccine development. …”

Variation of the factor H-binding protein of Neisseria meningitidis. by Brehony, C, Wilson, D, Maiden, M

Neisseria meningitidis lactate permease is required for nasopharyngeal colonization. by Exley, R, Goodwin, L, Mowe, E, Shaw, J, Smith, H, Read, R, Tang, C

“…Neisseria meningitidis is a human specific pathogen that is part of the normal nasopharyngeal flora. …”

Complete and variant forms of the 'gonococcal genetic island' in Neisseria meningitidis. by Snyder, L, Jarvis, SA, Saunders, N

“…Comparative genome hybridization using the pan-Neisseria microarray identified genes from the gonococcal genetic island (GGI) within Neisseria meningitidis strains of serogroups W-135, H, and Z. …”