Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults by Gaskell, H, Derry, S, Moore, R, McQuay, H, Moore, M

“…Background: Oxycodone is a strong opioid agonist used to treat severe pain. …”

Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults. by Gaskell, H, Derry, S, Moore, R, McQuay, H

“…BACKGROUND: Oxycodone is a strong opioid agonist used to treat severe pain. …”

Review: tricyclic antidepressants, capsaicin, gabapentin, and oxycodone are effective for postherpetic neuralgia. by Lancaster, T, McQuay, H

Abuse-deterrent extended-release oxycodone and risk of opioid-related harm by Paljarvi, T, Strang, J, Quinn, PD, Luciano, S, Fazel, S

“…</p> <p><strong>Participants:</strong> Patients aged 18–64 years at index health-care visit with any indication for an oral opioid analgesic, with no past 12-month history of oral oxycodone use or substance use disorder, and who were alive at the end of the 1-year follow-up (new episode of prescription oral ADF oxycodone [OxyContin], n = 45 045; new episode of non-ADF oxycodone opioid preparation, n = 1 377 359).…”

Single dose oral ibuprofen plus oxycodone for acute postoperative pain in adults. by Derry, S, Derry, C, Moore, R

“…For ibuprofen 400 mg alone the proportion was 50%, producing no significant difference between ibuprofen 400 mg + oxycodone 5 mg and ibuprofen 400 mg alone. For oxycodone 5 mg alone the proportion was 23%, giving an NNT for ibuprofen 400 mg + oxycodone 5 mg compared with oxycodone alone of 2.9 (2.3 to 4.0).Ibuprofen + oxycodone resulted in longer times to remedication than with placebo. …”

Opioids for cancer pain - an overview of Cochrane reviews. by Wiffen, P, Wee, B, Derry, S, Bell, R, Moore, R

“…</p> <h4> <p>Reviews on buprenorphine, codeine with or without paracetamol, hydromorphone,methadone, tramadol with or without paracetamol, tapentadol, and oxycodone did not have information about the primary outcome of mild or no pain at 14 days, although that on oxycodone indicated that average pain scores were within that range. …”

Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study. by Hawton, K, Bergen, H, Simkin, S, Wells, C, Kapur, N, Gunnell, D

“…The reduction in prescribing of co-proxamol following its withdrawal in 2005 was accompanied by increases in prescribing of several other analgesics (co-codamol, paracetamol, codeine, co-dydramol, tramadol, oxycodone, and morphine) during 2005-2010 compared with 1998-2004. …”

Global, regional, and national consumption of controlled opioids: a cross-sectional study of 214 countries and non-metropolitan territories by Richards, GC, Aronson, JK, Mahtani, KR, Heneghan, C

“…Consumption was the highest in Germany (480 mg/person), followed by Iceland (428 mg/person), the United States (398 mg/person) and Canada (333 mg/person). Oxycodone (35%) was the most heavily consumed controlled opioid globally, followed by morphine (15.9%), methadone (15.8%) and tilidine (14%). …”

Trends of dispensed opioids in Catalonia, Spain, 2007–19: a population-based cohort study of over 5 million individuals by Xie, J, Strauss, VY, Collins, GS, Khalid, S, Delmestri, A, Turkiewicz, A, Englund, M, Tadrous, M, Reyes, C, Prieto-Alhambra, D

“…<br><strong> Main exposure and outcomes: </strong>The exposures were all commercialized opioids and their combinations (ATC-codes): codeine, tramadol, oxycodone, tapentadol, fentanyl, morphine, and other opioids (dihydrocodeine, hydromorphone, dextropropoxyphene, buprenorphine, pethidine, pentazocine). …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Long duration of action (≥ 8 hours) was found for etoricoxib 120 mg, diflunisal 500 mg, oxycodone 10 mg + paracetamol 650 mg, naproxen 500/550 mg, and celecoxib 400 mg.Not all participants had good pain relief and for many drug/dose combinations 50% or more did not achieve at last 50% maximum pain relief over four to six hours. …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Long duration of action (≥ 8 hours) was found for etoricoxib 120 mg, diflunisal 500 mg, oxycodone 10 mg + paracetamol 650 mg, naproxen 500/550 mg, and celecoxib 400 mg.Not all participants had good pain relief and for many drug/dose combinations 50% or more did not achieve at last 50% maximum pain relief over four to six hours. …”