Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial. by Geddes, J, Gardiner, A, Rendell, J, Voysey, M, Tunbridge, E, Hinds, C, Yu, L, Hainsworth, J, Attenburrow, M, Simon, J, Goodwin, G, Harrison, P

“…The combination of lamotrigine plus quetiapine potentially offers improved outcomes for people with bipolar depression. …”

Quetiapine more effective than placebo for depression in bipolar I and II disorder. by Goodwin, G

An economic assessment of quetiapine and haloperidol in patients with schizophrenia only partially responsive to conventional antipsychotics. by Tilden, D, Aristides, M, Meddis, D, Burns, T

“…The total treatment cost over 5 years was 38,106 pounds for quetiapine and 38,350 pounds for haloperidol, a cost saving of 244 pounds in favor of quetiapine. …”

Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randomised double blind placebo controlled trial. by Ballard, C, Margallo-Lana, M, Juszczak, E, Douglas, S, Swann, A, Thomas, A, O'Brien, J, Everratt, A, Sadler, S, Maddison, C, Lee, L, Bannister, C, Elvish, R, Jacoby, R

“…RESULTS: 31 patients were randomised to each group, and 80 (86%) started treatment (25 rivastigmine, 26 quetiapine, 29 placebo), of whom 71 (89%) tolerated the maximum protocol dose (22 rivastigmine, 23 quetiapine, 26 placebo). …”

Study protocol for a randomised pragmatic trial comparing the clinical and cost effectiveness of Lithium and Quetiapine augmentation in treatment resistant Depression (the LQD study) by Marwood, L, Taylor, R, Goldsmith, K, Romeo, R, Holland, R, Pickles, A, Hutchinson, J, Dietch, D, Cipriani, A, Nair, R, Attenburrow, M-J, Young, AH, Geddes, JR, McAllister-Williams, RH, Cleare, AJ

“…Lithium and the atypical antipsychotic quetiapine are two such add-on therapies and are currently recommended as first line options for treatment resistant depression. …”

Short-term quetiapine treatment alters the use of reinforcement signals during risky decision-making and promotes the choice of negative expected values in healthy adult males. by Rock, P, Harmer, C, McTavish, S, Goodwin, G, Rogers, R

“…Here, we investigated the effects of (short-term) treatment with quetiapine on the risky decision-making of healthy human adults. …”

Lithium vs. valproate vs. olanzapine vs. quetiapine as maintenance monotherapy for bipolar disorder: a population-based UK cohort study using electronic health records. by Hayes, J, Marston, L, Walters, K, Geddes, J, King, M, Osborn, D

“…We aimed to compare rates of monotherapy treatment failure in individuals prescribed lithium, valproate, olanzapine or quetiapine by a population-based cohort study using electronic health records. 5,089 patients with bipolar disorder were prescribed lithium (N=1,505), valproate (N=1,173) olanzapine (N=1,366) or quetiapine (N=1,075) as monotherapy. …”

Pharmacological treatment and risk of psychiatric hospital admission in bipolar disorder by Goodwin, G, Joas, E, Karanti, A, Song, J, Lichtenstein, P, Landén, M

“…Lithium was more effective than quetiapine and olanzapine. The effects of specific drugs depended on the polarity of the mood episode.…”

Adverse renal, endocrine, hepatic, and metabolic events during maintenance mood stabilizer treatment for bipolar disorder: a population-based cohort study by Hayes, J, Marston, L, Walters, K, Geddes, J, King, M, Osborn, D

“…We included patients who had a diagnosis of bipolar disorder and were prescribed lithium (n = 2148), valproate (n = 1670), olanzapine (n = 1477), or quetiapine (n = 1376) as maintenance mood stabilizer treatment. …”

Lamotrigine Therapy for Bipolar Depression: Analysis of Self-Reported Patient Data by Nzeyimana, A, Saunders, KEA, Geddes, JR, McSharry, PE

“…A double-blinded randomized placebo-controlled trial (comparative evaluation of Quetiapine-Lamotrigine [CEQUEL] study) was conducted to evaluate the efficacy of lamotrigine plus quetiapine versus quetiapine monotherapy in patients with bipolar type I or type II disorders. …”

Self-harm, accidental injury, and suicide in bipolar disorder during maintenance mood stabilizer treatment: a UK population-based electronic health records study by Hayes, J, Pitman, A, Marston, L, Walters, K, Geddes, J, King, M, Osborn, D

“…After propensity score adjustment, accidental injury rates were lower in lithium compared to valproate (HR 1.32; 95%CI 1.10-1.58) and quetiapine (HR 1.34; 95%CI 1.07-1.69), but not olanzapine. …”

Comparative efficacy and acceptability of antimanic drugs in acute mania: A multiple-treatments meta-analysis by Cipriani, A, Barbui, C, Salanti, G, Rendell, J, Brown, R, Stockton, S, Purgato, M, Spineli, L, Goodwin, G, Geddes, J

“…Olanzapine, risperidone, and quetiapine led to significantly fewer discontinuations than did lithium, lamotrigine, placebo, topiramate, and gabapentin. …”

Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. by Cipriani, A, Barbui, C, Salanti, G, Rendell, J, Brown, R, Stockton, S, Purgato, M, Spineli, L, Goodwin, G, Geddes, J

“…Olanzapine, risperidone, and quetiapine led to significantly fewer discontinuations than did lithium, lamotrigine, placebo, topiramate, and gabapentin. …”

Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial by Tunbridge, E, Attenburrow, M, Gardiner, A, Rendell, J, Hinds, C, Goodwin, G, Harrison, P, Geddes, J

“…<p><strong>Objectives</strong> CEQUEL (Comparative Evaluation of QUEtiapine plus Lamotrigine combination versus quetiapine monotherapy [and folic acid versus placebo] in bipolar depression) was a double‐blind, randomized, placebo‐controlled, parallel group, 2×2 factorial trial that examined the effect of adding lamotrigine and/or folic acid (FA) to quetiapine in bipolar depression. …”

A systematic review of the use of atypical antipsychotics in autism. by Barnard, L, Young, A, Pearson, J, Geddes, J, O'Brien, G

“…Olanzapine and clozapine may also be effective; however, there is little evidence for using amisulpride or quetiapine in this population. Randomized trials are required to clarify the effectiveness of these agents.…”

Bipolar disorder by Goodwin, G

“…For an early treatment effect, quetiapine, lurasidone (unlicensed indication) or olanzapine can be useful. …”

Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder by Cipriani, A, Barbui, C, Rendell, J, Geddes, J

“…Results: Six placebo-controlled trials comparing aripiprazole, olanzapine, quetiapine and ziprasidone were found in the FDA website. …”

Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder. by Cipriani, A, Barbui, C, Rendell, J, Geddes, J

“…RESULTS: Six placebo-controlled trials comparing aripiprazole, olanzapine, quetiapine and ziprasidone were found in the FDA website. …”

Bipolar disorder by Goodwin, G

“…For an early treatment effect quetiapine is useful. Lamotrigine requires dose titration but is well tolerated and a possible monotherapy in BD-II. …”

Associations between individual antipsychotics and the risk of arrests and convictions of violent and other crime: a nationwide within-individual study of 74 925 persons by Sariaslan, A, Leucht, S, Zetterqvist, J, Lichtenstein, P, Fazel, S

“…We found that clozapine (aRRs: 0.28–0.44), olanzapine (aRRs: 0.46–0.72), and risperidone (aRRs: 0.53–0.64) were associated with lower arrest and conviction risks than other antipsychotics, including quetiapine (aRRs: 0.68–0.84) and haloperidol (aRRs: 0.67–0.77). …”