Opportunity Knocks? The Possibilities and Levers for Improving Job Quality by Findlay, P, Warhurst, C, Keep, E, Lloyd, C

Knock-out and transgenic mouse models of tauopathies. by Denk, F, Wade-Martins, R

“…Here we review the range of Mapt knock-out and MAPT transgenic mouse models which have proven successful at providing insights into the molecular mechanisms of neurodegenerative disease. …”

Knock measurement for fuel evaluation in spark ignition engines by Hudson, C, Gao, X, Stone, R

Increasing knock-in efficiency in mouse zygotes by transient hypothermia by Bouchareb, A, Biggs, D, Alghadban, S, Preece, C, Davies, B

“…Taken together, our data suggest that a transient cold shock could offer a simple and robust way to improve knock-in outcomes in both stem cells and zygotes. …”

Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7. by Kessler, B, Fortunati, E, Melis, M, Pals, C, Clevers, H, Maurice, M

Gene Correction of a Duchenne Muscular Dystrophy Mutation by Meganuclease-Enhanced Exon Knock-In by Popplewell, L, Koo, T, Leclerc, X, Duclert, A, Mamchaoui, K, Gouble, A, Mouly, V, Voit, T, Pâques, F, Cédrone, F, Isman, O, Yáñez-Muñoz, R, Dickson, G

Knocking out pain in livestock: can technology succeed where morality has stalled? by Shriver, A

Knock-down of ELMO1 in paediatric Rhabdomyosarcoma cells by nanoparticle mediated siRNA delivery by Huang, X, Townley, H

“…The ARMS subtype has higher rates of metastasis, as well as higher levels of ELMO1, which is thought to be involved in cell migration. Therefore, the knock-down of ELMO1 by targeted siRNA could provide a mechanism to prevent the metastatic behaviour of ARMS cells. …”

Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. by Tuoc, T, Radyushkin, K, Tonchev, AB, Piñon, M, Ashery-Padan, R, Molnár, Z, Davidoff, MS, Stoykova, A

Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice. by Piñon, M, Tuoc, T, Ashery-Padan, R, Molnár, Z, Stoykova, A

“…Herein, we analyzed the role of Pax6 in molecular arealization and development of thalamocortical connections in the juvenile cortex-specific conditional Pax6 knock-out mice (Pax6cKO). Using a set of molecular markers of positional identity (Id2, Cadherin6, COUP-TF1, RZRbeta, and EphA7), we show that, in the juvenile Pax6cKO, the relative size of caudal cortical areas (putative visual and somatosensory) are mildly enlarged, whereas the rostral domain (putative motor) is severely reduced. …”

MODELLING CALCIUM HANDLING MECHANISMS IN NORMAL AND NEURONAL NITRIC OXIDE SYNTHASE KNOCK-OUT MOUSE HEARTS by Li, L, Niederer, SA, Idigo, W, Zhang, Y, Casadei, B, Smith, N

Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. by Sakura, H, Ashcroft, S, Terauchi, Y, Kadowaki, T, Ashcroft, F

“…Glucose fails to stimulate insulin secretion in mice in which the glucokinase gene has been selectively knocked out in the beta cell. We tested the hypothesis that this effect results from defective metabolic regulation of beta cell ATP-sensitive potassium (K(ATP)) channels. …”

Rescue of secretion of rare-disease associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells by Tax, G, Guay, K, Pantalone, L, Ceci, M, Soldà, T, Hitchman, C, Hill, J, Vasiljevic, S, Lia, A, Modenutti, C, Straatman, K, Santino, A, Molinari, M, Zitzmann, N, Hebert, D, Roversi, P, Trerotola, M

Imaging synaptic vesicles using VGLUT1-venus knock-in mice: insights into the dynamic nature of intersynaptic vesicle exchange. by Padamsey, Z, Jeans, A

DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact by Rawlings-Mortimer, F, Gullino, LS, Rühling, S, Ashton, A, Barkus, C, Johansen-Berg, H

“…Here, we assess whether Dusp15 is reduced in the hippocampus of mice with conditional knock-out of Myrf in oligodendrocyte precursor cells. …”

The pyrethroid knock-down resistance gene in the Anopheles gambiae complex in Mali and further indication of incipient speciation within An. gambiae s.s. by Fanello, C, Petrarca, V, della Torre, A, Santolamazza, F, Dolo, G, Coulibaly, M, Alloueche, A, Curtis, C, Touré, Y, Coluzzi, M

“…The population structure of An. gambiae s.l. was analysed in three villages in the Bamako and Sikasso areas of Mali and the frequency of pyrethroid resistance of the knock-down resistance (kdr) type was calculated. …”

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice by Volta, M, Beccano-Kelly, DA, Paschall, SA, Cataldi, S, MacIsaac, SE, Kuhlmann, N, Kadgien, CA, Tatarnikov, I, Fox, J, Khinda, J, Mitchell, E, Bergeron, S, Melrose, H, Farrer, MJ, Milnerwood, AJ

“…LRRK2 pathophysiology remains unclear, but reduced dopamine and mitochondrial abnormalities occur in aged G2019S mutant knock-in (GKI) mice. Conversely, cultured GKI neurons exhibit increased synaptic transmission. …”

Characterization of the Frmd7 Knock-Out Mice Generated by the EUCOMM/COMP Repository as a Model for Idiopathic Infantile Nystagmus (IIN) by Salman, A, Hutton, SB, Newall, T, Scott, JA, Griffiths, HL, Lee, H, Gomez-Nicola, D, Lotery, AJ, Self, JE

“…<div>In this study, we seek to exclude other pathophysiological mechanisms by which&nbsp;Frmd7&nbsp;knock-down may cause Idiopathic Infantile Nystagmus (IIN) using the&nbsp;Frmd7^.tm1a&nbsp;and&nbsp;Frmd7^.tm1b&nbsp;murine models. …”

Paclitaxel sensitivity of ovarian cancer can be enhanced by knocking down pairs of kinases that regulate MAP4 phosphorylation and microtubule stability by Yang, H, Mao, W, Rodriguez-Aguayo, C, Mangala, L, Bartholomeusz, G, Iles, L, Jennings, N, Ahmed, A, Sood, A, Lopez-Berestein, G, Lu, Z, Bast, R

Control of knock-on damage for 3D atomic scale quantification of nanostructures: Making every electron count in scanning transmission electron microscopy by Van Aert, S, De Backer, A, Jones, L, Martinez, G, Béché, A, Nellist, P

“…An important challenge is therefore to develop experimental strategies to optimize the electron dose by balancing atom-counting fidelity vs the risk of knock-on damage. To achieve this goal, a statistical framework combined with physics-based modeling of the dose-dependent processes is here proposed and experimentally verified. …”