"I think of Chaplin": Poetry and the Tramp in Cold War America by Potts, G

Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model by Philippou, Y, Sjoberg, HT, Murphy, E, Alyacoubi, S, Jones, KI, Gordon-Weeks, AN, Phyu, S, Parkes, EE, McKenna, WG, Lamb, AD, Gileadi, U, Cerundolo, V, Scheiblin, DA, Lockett, SL, Wink, DA, Mills, IG, Hamdy, FC, Muschel, RJ, Bryant, RJ

“…TRAMP-C1 allografts were then treated with 3 × 5 Gy ± anti-PD-L1.…”

Investigating radiotherapy response in a novel syngeneic model of prostate cancer by Haughey, CM, Mukherjee, D, Steele, RE, Popple, A, Dura-Perez, L, Pickard, A, Patel, M, Jain, S, Mullan, PB, Williams, R, Oliveira, P, Buckley, NE, Honeychurch, J, S McDade, S, Illidge, T, Mills, IG, Eddie, SL

“…Compared to the commonly used TRAMP C1 model, generated with SV40 large T-antigen, DVL3 tumours are immunologically cold, with a lower proportion of CD8+ T-cells, and high proportion of immunosuppressive myeloid derived suppressor cells (MDSCs), thus resembling high-risk PCa. …”

Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing. by Wang, S, Stevenson, A, Kearsey, S, Watt, S, Bähler, J

“…Fission yeast Cid14, a component of the TRAMP (Cid14/Trf4-Air1-Mtr4 polyadenylation) complex, polyadenylates nuclear RNA and stimulates degradation by the exosome for RNA quality control. …”

Tumour irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumour effects in preclinical prostate cancer by Sjoberg, H, Philippou, Y, Magnussen, A, Tullis, I, Bridges, E, Chatrian, A, Lefebvre, J, Tam, KH, Murphy, E, Rittscher, J, Preise, D, Agemy, L, Yechezkel, T, Smart, S, Kinchesh, P, Gilchrist, S, Allen, D, Scheiblin, D, Lockett, S, Wink, D, Lamb, A, Mills, I, Harris, A, Muschel, R, Vojnovic, B, Scherz, A, Hamdy, F, Bryant, R

“…</p> <p><strong>Methods:</strong> We investigated whether sequential delivery of FRT followed by VTP 7 days later improves flank TRAMP-C1 PCa tumour allograft control compared to monotherapy with FRT or VTP.…”