Plant cell polarity: the ins-and-outs of sterol transport. by Betts, H, Moore, I

“…Recent studies highlight the important role of membrane sterols in plant cell polarity and suggest that sterols may influence the dynamic trafficking of proteins with polar distributions in the plasma membrane.…”

Shmoos, rafts, and uropods- the many facets of cell polarity. by Dustin, M

Epithelial cell polarity: A major gatekeeper against cancer by Royer, C, Lu, X

“…The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. …”

ADF/cofilin controls cell polarity during fibroblast migration. by Dawe, H, Minamide, L, Bamburg, JR, Cramer, L

“…Cell polarity was rescued by coexpressing an active, nonphosphorylatable Xenopus AC (CA XAC) with the CA LIMK. …”

Epithelial cell polarity: a major gatekeeper against cancer? by Royer, C, Lu, X

“…The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. …”

Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. by Hagemann, T, Wilson, J, Burke, F, Kulbe, H, Li, N, Plüddemann, A, Charles, K, Gordon, S, Balkwill, F

Ovarian cancer cells polarize macrophages towards a tumor-associated phenotype by Hagemann, T, Wilson, J, Burke, F, Kulbe, H, Li, N, Pluddemann, A, Charles, K, Gordon, S, Balkwill, F

ST2 regulates allergic airway inflammation and T-Cell polarization in epicutaneously sensitized mice by Savinko, T, Karisola, P, Lehtimäki, S, Lappeteläinen, A, Haapakoski, R, Wolff, H, Lauerma, A, Alenius, H

ST2 regulates allergic airway inflammation and T-cell polarization in epicutaneously sensitized mice. by Savinko, T, Karisola, P, Lehtimäki, S, Lappeteläinen, A, Haapakoski, R, Wolff, H, Lauerma, A, Alenius, H

Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability. by Kim, H, Claps, G, Möller, A, Bowtell, D, Lu, X, Ronai, Z

“…In all, our studies demonstrate the role of Siah2 in regulation of TJ integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.…”

Planar cell polarity effector proteins inturned and fuzzy form a Rab23 GEF complex by Gerondopoulos, A, Strutt, H, Stevenson, N, Sobajima, T, Levine, T, Stephens, D, Strutt, D, Barr, F

“…These findings extend the family of longin domain GEFs and define a molecular activity linking Rab23-regulated membrane traffic to cilia and planar cell polarity.…”

The Bardet–Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly by Cassioli, C, Onnis, A, Finetti, F, Capitani, N, Brunetti, J, Compeer, EB, Niederlova, V, Stepanek, O, Dustin, ML, Baldari, CT

STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. by Turnquist, C, Wang, Y, Severson, D, Zhong, S, Sun, B, Ma, J, Constaninescu, SN, Ansorge, O, Stolp, H, Molnár, Z, Szele, F, Lu, X

“…Inflammation and loss of cell polarity play pivotal roles in neurodegeneration and cancer. …”

CagA-ASPP2 complex mediates loss of cell polarity and favours H.pylori colonisa-tion of human gastric organoids by Buti, L, Ruiz-Puig, C, Sangberg, D, Leissing, T, Brewer, RC, Owen, RP, Sgromo, B, Royer, C, Ebner, D, Lu, X

“…However, the mechanism by which CagA disrupts gastric epithelial cell polarity to achieve its oncogenicity is not fully understood. …”

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye. by Amin, N, Khan, A, St Johnston, D, Tomlinson, I, Martin, S, Brenman, J, McNeill, H

“…The serine-threonine kinase LKB1 regulates cell polarity from Caenorhabditis elegans to man. Loss of lkb1 leads to a cancer predisposition, known as Peutz-Jeghers Syndrome. …”

ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. by Sottocornola, R, Royer, C, Vives, V, Tordella, L, Zhong, S, Wang, Y, Ratnayaka, I, Shipman, M, Cheung, A, Gaston-Massuet, C, Ferretti, P, Molnár, Z, Lu, X

“…Cell polarity plays a key role in the development of the central nervous system (CNS). …”

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. by Dawe, H, Adams, M, Wheway, G, Szymanska, K, Logan, C, Noegel, A, Gull, K, Johnson, C

“…However, in ciliated-cell models, meckelin and nesprin-2 isoforms colocalized at filopodia prior to the establishment of cell polarity and ciliogenesis. Loss of nesprin-2 and nesprin-1 shows that both mediate centrosome migration and are then essential for ciliogenesis, but do not otherwise affect apical-basal polarity. …”

Synaptic asymmetry to go. by Dustin, M

“…Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. …”

p21-activated kinase 1: PAK'ed with potential. by Ong, C, Jubb, A, Zhou, W, Haverty, P, Harris, A, Belvin, M, Friedman, L, Koeppen, H, Hoeflich, K

“…The p21-activated kinases (PAKs) are central players in growth factor signaling networks and morphogenetic processes that control proliferation, cell polarity, invasion and actin cytoskeleton organization. …”

Novel therapeutic strategies: targeting epithelial–mesenchymal transition in colorectal cancer by Zhang, N, Ng, AS, Cai, S, Li, Q, Yang, L, Kerr, D

“…Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain mesenchymal properties, such as increased motility. …”