Changing interpretations of emotional expressions in working memory with aging by Mok, R, Hajonides Van Der Meulen, J, Holmes, E, Nobre, A

“Stop … and remember”: Memory and ageing in Kazuo Ishiguro’s novels by Charlwood, C

“…Ishiguro is more interested in socio-cultural meanings of ageing than biologically impoverished memories: this article examines the shifting relationships Ishiguro presents between memory and age as regards what happens to the ways in which memories are valued, and how people might be valuable (or not) for their memories. …”

Neural markers of category-based selective working memory in aging by Mok, R, O'Donoghue, C, Myers, N, Drazich, E, Nobre, A

Behavioral and neural markers of flexible attention over working memory in aging by Mok, R, Myers, N, Wallis, G, Nobre, A

Association of Gestational Age with Verbal Ability and Spatial Working Memory at Age 11 by Fitzpatrick, A, Carter, J, Quigley, M

Overgeneral autobiographical memory and age of onset of childhood sexual abuse in patients with recurrent suicidal behaviour. by Crane, C, Duggan, D

Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort by Patel, D, Lunn, A, Smith, A, Lehmann, D, Dorrington, K

Cerebral subcortical small vessel disease in subjects with pathologically confirmed alzheimer disease: A clinicopathologic study in the oxford project to investigate memory and ageing (OPTIMA) by Esiri, M, Joachim, C, Sloan, C, Christie, S, Agacinski, G, Bridges, L, Wilcock, G, Smith, A

“…A previous study from the Oxford Project to Investigate Memory and Ageing (OPTIMA) validated a scheme for assessing the contribution of subcortical small vessel disease (SVD) toward dementia in the elderly by showing a significant inverse relationship between the severity of SVD and cognition in subjects without any other dementia pathology using this method. …”

3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice by Sasaki, K, Davies, J, Doldán, N, Arao, S, Ferdousi, F, Szele, F, Isoda, H

Cerebral subcortical small vessel disease in subjects with pathologically confirmed Alzheimer disease: a clinicopathologic study in the Oxford Project to Investigate Memory and Ageing (OPTIMA). by Esiri, M, Joachim, C, Sloan, C, Christie, S, Agacinski, G, Bridges, L, Wilcock, G, Smith, A

“…A previous study from the Oxford Project to Investigate Memory and Ageing (OPTIMA) validated a scheme for assessing the contribution of subcortical small vessel disease (SVD) toward dementia in the elderly by showing a significant inverse relationship between the severity of SVD and cognition in subjects without any other dementia pathology using this method. …”

The CT-based radial width of the temporal horn: pathological validation in AD without cerebrovascular disease. by Rossi, R, Joachim, C, Smith, A, Frisoni, G

“…METHOD: The rWTH was taken in a group of 20 pathologically confirmed AD patients and 23 non demented persons enrolled in the Oxford Project to Investigate Memory and Aging (OPTIMA project). RESULTS: The rWTH was significantly larger in AD patients than controls. …”

The brain ages optimally to model its environment: evidence from sensory learning over the adult lifespan by Moran, R, Symmonds, M, Dolan, R, Friston, K

“…The aging brain shows a progressive loss of neuropil, which is accompanied by subtle changes in neuronal plasticity, sensory learning and memory. Neurophysiologically, aging attenuates evoked responses--including the mismatch negativity (MMN). …”

An assessment of neurocognitive speed in relation to frailty. by Rolfson, D, Wilcock, G, Mitnitski, A, King, E, de Jager, C, Rockwood, K, Fallah, N, Searle, S

“…DESIGN: secondary analysis of the baseline cohort of the Oxford Project To Investigate Memory and Aging (OPTIMA), a longitudinal observational cohort. …”

The Brain Ages Optimally to Model Its Environment: Evidence from Sensory Learning over the Adult Lifespan by Moran, R, Symmonds, M, Dolan, R, Friston, K

“…The aging brain shows a progressive loss of neuropil, which is accompanied by subtle changes in neuronal plasticity, sensory learning and memory. Neurophysiologically, aging attenuates evoked responses-including the mismatch negativity (MMN). …”

Association study of MICA and MICB in Alzheimer's disease. by Quiroga, I, Lehmann, D, Barnardo, M, Fuggle, S, Cortina-Borja, M, Warden, DR, Smith, A

“…Following the replication of the association of the human leucocyte antigen (HLA) allele, HLA-B*07, with Alzheimer's disease (AD) in the cohort of the Oxford Project to Investigate Memory and Ageing (OPTIMA) in a previous study, we examined whether that association could be due to linkage disequilibrium with MICA or MICB alleles. …”

Association study of MICA and MICB in Alzheimer's disease: BRIEF COMMUNICATION by Quiroga, I, Lehmann, D, Barnardo, M, Fuggle, S, Cortina-Borja, M, Warden, DR, Smith, A

“…Following the replication of the association of the human leucocyte antigen (HLA) allele, HLA-B*07, with Alzheimer's disease (AD) in the cohort of the Oxford Project to Investigate Memory and Ageing (OPTIMA) in a previous study, we examined whether that association could be due to linkage disequilibrium with MICA or MICB alleles. …”

Apolipoprotein E epsilon4 and testosterone interact in the risk of Alzheimer's disease in men. by Hogervorst, E, Lehmann, D, Warden, DR, McBroom, J, Smith, A

“…METHOD: We included 61 men with definite or probable Alzheimer's disease (AD) and 55 elderly male controls from the Oxford Project to Investigate Memory and Ageing (OPTIMA). Testosterone was measured using a competitive enzyme immunoassay (Bayer). …”

Cerebral amyloid angiopathy, subcortical white matter disease and dementia: literature review and study in OPTIMA. by Esiri, M, Chance, S, Joachim, C, Warden, D, Smallwood, A, Sloan, C, Christie, S, Wilcock, G, Smith, A

“…In this article, the literature on this subject is reviewed and novel findings relating CAA to subcortical white matter damage in 224 subjects in the Oxford project to Investigate Memory and Ageing (OPTIMA) are reported. The relationship between CAA and subcortical tissue damage in the OPTIMA subjects was found to be critically dependent on ApoE genotype, there being a positive relationship between measures of CAA and subcortical small vessel disease in ApoEε4 carriers and a significant negative relationship in ApoEε2 carriers. …”

White matter integrity as a marker for cognitive plasticity in ageing by de Lange, A, Bråthen, A, Sexton, C, Johansen-Berg, H, Grydeland, H, Andresson, J, Rohani, D, Nyberg, L, Fjell, A, Walhovd, K

“…The results showed that only the group receiving training improved their memory. Significant age differences in MD and FA were found in widespread areas. …”

Memory encoding and dopamine in the aging brain: a psychopharmacological neuroimaging study. by Morcom, A, Bullmore, E, Huppert, F, Lennox, B, Praseedom, A, Linnington, H, Fletcher, P

“…These findings suggest that brain systems underlying memory show age-related changes and that dopaminergic function may be key in understanding these changes. …”