The Cinderella syndrome: why do malaria-infected cells burst at midnight? by Mideo, N, Reece, SE, Smith, A, Metcalf, C

The Cinderella syndrome: Why do malaria-infected cells burst at midnight? by Mideo, N, Reece, SE, Smith, A, Metcalf, C

Life in the land of the midnight sun: are northern lizards adapted to longer days? by Uller, T, Olsson, M

A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome. by Newell-Price, J, Trainer, P, Perry, L, Wass, J, Grossman, A, Besser, M

“…RESULTS: In all the control subjects the sleeping midnight cortisol was < 50 nmol/l, below the lowest standard of the routine in-house RIA. …”

Constant light desynchronises olfactory versus object and visuospatial recognition memory performance by Tam, S, Hasan, S, Choi, H, Brown, L, Jagannath, A, Hughes, S, Hankins, M, Foster, R, Vyazovskiy, V, Bannerman, D, Peirson, S

“…Here we demonstrate for the first time that, under standard 12-h:12-h light–dark cycles (LD), object, visuospatial, and olfactory recognition performance in C57BL/6J mice is consistently better at midday relative to midnight. However, under repeated exposure to constant light (rLL), recognition performance becomes desynchronised, with object and visuospatial performance better at subjective midday and olfactory performance better at subjective midnight. …”

Deconvolution analysis of 24-h serum cortisol profiles informs the amount and distribution of hydrocortisone replacement therapy. by Peters, C, Hill, N, Dattani, M, Charmandari, E, Matthews, DR, Hindmarsh, P

“…Timing of the peak serum cortisol concentration was similar (07.05-07.25), whereas that of the nadir concentration occurred later in adults (midnight) compared with children (22.48) (P = 0.003). …”

Abnormal puberty in paediatric Cushing's disease: relationship with adrenal androgen, sex hormone binding globulin and gonadotrophin concentrations. by Dupuis, C, Storr, H, Perry, L, Ho, J, Ahmed, L, Ong, K, Dunger, D, Monson, J, Grossman, AB, Besser, G, Savage, M

“…A4, DHEAS, T, SHBG, LH and FSH did not correlate with midnight cortisol, but A4 and T SDS correlated with ACTH at 09.00 h (both r = 0.51). …”

Why India’s democracy is dying by Tudor, M

“…And the modality of India’s democratic decline reveals how democracies die today: not through a dramatic coup or midnight arrests of opposition leaders, but instead, it moves through the fully legal harassment of the opposition, intimidation of media, and centralization of executive power. …”

The investigation of Cushing syndrome: essentials in optimizing appropriate diagnosis and management. by Juszczak, A, Grossman, A

“…The recommended first-line tests include midnight salivary cortisol and/or the 1 mg overnight or low-dose dexamethasone suppression tests. …”

Tracking urban human activity from mobile phone calling patterns by Monsivais, D, Ghosh, A, Bhattacharya, K, Dunbar, R, Kaski, K

“…We also find that the onset and termination of the calling activity of users follows a yearly dynamics, varying across seasons, and that its timings are entrained to solar midnight. Furthermore, we show that the average mid-sleep time of people living in urban areas depends on the age and gender of each cohort as a result of biological and social factors.…”

Diurnal variation in the effect of melatonin on neurohypophysial hormone release from the rat hypothalamus. by Yasin, SA, Grossman, A, Forsling, M

“…Basal release of hormone was not influenced by the time of day when the animals were taken, although stimulated release was elevated at midnight. In groups A and B both doses of melatonin significantly reduced basal and stimulated release of vasopressin and basal release of oxytocin (p < 0.01), although no effect was seen in group C animals. …”

A study of the workload and effectiveness of a comprehensive acute stroke service. by Weir, N, Buchan, A

“…RESULTS: The CSP received 572 referrals (median: 32 per week), 88% of which were made between 7 am and midnight. Of the 427 patients seen in person, 29% had not had an acute stroke or transient ischaemic attack (TIA). …”

Is urinary free cortisol of value in the diagnosis of Cushing's syndrome? by Alexandraki, K, Grossman, AB

“…Biochemical tests are always needed to confirm the clinical suspicion: these include measurement of excess total endogenous cortisol secretion assessed by 24-h urinary free cortisol (UFC), loss of the normal feedback of the hypothalamo-pituitary-adrenal axis assessed by suppressibility after dexamethasone testing, and disturbance of the normal circadian rhythm of cortisol secretion assessed by midnight serum or salivary cortisol. This review focuses on recent data emerging on the value of UFC as a screening test for Cushing's syndrome. …”

Novel insights in the diagnosis of Cushing's syndrome. by Alexandraki, K, Grossman, AB

“…Many studies have examined the utility of resistance to steroid feedback by the dexamethasone suppression tests and increases in secretion assessing 24-hour urinary free cortisol; however, the most sensitive indicator is the loss of circadian rhythmicity. Therefore, midnight sleeping cortisol is undoubtedly an extremely sensitive indicator of CS but impractical for screening purposes. …”

Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease. by Peters, C, Ahmed, M, Storr, H, Davies, K, Martin, L, Allgrove, J, Grossman, AB, Savage, M

“…No relationships were found with midnight cortisol, ACTH, DHEA-S or cortisol suppression during the low-dose dexamethasone suppression test. …”

Differential diagnosis of adrenocorticotropic hormone-independent Cushing syndrome: role of adrenal venous sampling. by Martins, R, Agrawal, R, Berney, D, Reznek, R, Matson, M, Grossman, AB, Druce, MR

“…RESULTS: The patient reported a prior personal history of asthma, type 2 diabetes mellitus, hypertension, dyslipidemia, and bilateral leg ulcers, but she denied having any personal or family history of endocrinopathy and was not taking any corticosteroid medication. Elevated midnight serum cortisol, failure to suppress cortisol levels with a low-dose dexamethasone suppression test, and undetectable plasma ACTH all indicated ACTH-independent CS. …”

The management of Cushing's disease - from investigation to treatment. by Juszczak, A, Grossman, A

“…If the initial test is positive on two occasions, the patient should be referred to a specialist endocrinologist for in-patient assessment, while elevated midnight serum cortisol and a low dose dexamethasone suppression test will confirm endogenous hypercortisolaemia. …”

Continuous administration of human corticotropin-releasing hormone in the absence of glucocorticoid feedback in man. by Ur, E, Capstick, C, McLoughlin, L, Checkley, S, Besser, G, Grossman, A

“…Circadian rhythm of ACTH was maintained, with a fall in the evening to 14.5 +/- 4 pg/ml (mean +/- SE) at midnight and an exaggerated rise overnight, reaching a peak level of 90 +/- 33 pg/ml at 07:00 h. …”

New prototype screened doors and windows for excluding mosquitoes from houses: A pilot study in rural Gambia by Jawara, M, Jatta, E, Bell, D, Burkot, T, Bradley, J, Hunt, V, Kandeh, B, Jones, C, Manjang, A, Pinder, M, Stone, S, D'Alessandro, U, Knudsen, J, Lindsay, S

“…Seventy-nine percentage of door openings at night occurred from dusk to midnight, when malaria vectors begin entering houses. …”

The differential diagnosis of Cushing's syndrome. by Newell-Price, J, Grossman, AB

“…A cortisol level below 50 nmol/l at midnight rules out active Cushing's syndrome with, in our experience, 100% sensitivity and a specificity depending on numerous other variables. …”