Thalamic neurodegeneration in multiple sclerosis. by Cifelli, A, Arridge, M, Jezzard, P, Esiri, M, Palace, J, Matthews, P

Inflammation versus neurodegeneration: consequences for treatment. by Palace, J

“…Inflammation is assumed to be the main driver of neurodegeneration in multiple sclerosis. However there is evidence that questions this hypothesis: Data from pathological studies and from imaging have shown that neuronal/axonal damage occurs early in lesion formation and at the earliest clinical stage of the disease. …”

The contribution of inflammation to acute and chronic neurodegeneration. by Perry, V, Bolton, S, Anthony, D, Betmouni, S

Role of senataxin in R-loop-mediated neurodegeneration by Kannan, A, Gangadharan Leela, S, Branzei, D, Gangwani, L

Thalamic neurodegeneration in relapsing-remitting multiple sclerosis. by Wylezinska, M, Cifelli, A, Jezzard, P, Palace, J, Alecci, M, Matthews, P

Senataxin: genome guardian at the interface of transcription and neurodegeneration by Groh, M, Albulescu, L, Cristini, A, Gromak, N

“…We will discuss the importance of SETX as a genome guardian in suppressing aberrant R-loop formation and analyse how SETX mutations can lead to neurodegeneration in AOA2/ALS4. Finally, we will discuss the implications for other R-loop-associated neurodegenerative diseases and point to future therapeutic approaches to treat these disorders.…”

The mitochondrial brain: From mitochondrial genome to neurodegeneration. by Turnbull, H, Lax, N, Diodato, D, Ansorge, O, Turnbull, D

“…The clinical course varies considerably but in many patients there is a progressive decline, and in some evidence of marked neurodegeneration. Our understanding of the mechanisms involved is limited due in part to limited availability of animal models of disease. …”

The interplay between inflammation and neurodegeneration in CNS disease. by Esiri, M

“…This review considers the manner in which inflammation in the CNS contributes to, and protects against, neurodegeneration. A series of questions are posed, first about primarily inflammatory diseases and the causes of neurodegeneration that occurs in them, and then about neurodegenerative diseases and stroke and the role that inflammation plays there. …”

Neurodegeneration behind bars: from molecules to jurisprudence by Sfera, A, Osorio, C, Gradini, R, Price, A

Vascular smooth muscle cell dysfunction in neurodegeneration by Hayes, G, Pinto, J, Sparks, SN, Wang, C, Suri, S, Bulte, DP

“…An increasing body of research suggests that VSMCs have remarkable plasticity and their pathophysiology may play a key role in the complex process of neurodegeneration. Furthermore, extrinsic risk factors, including environmental conditions and traumatic events can impact vascular function through changes in VSMC morphology. …”

Oxidative stress mediates tau-induced neurodegeneration in Drosophila. by Dias-Santagata, D, Fulga, T, Duttaroy, A, Feany, M

“…We used a Drosophila model of human tauopathies to investigate the role of oxidative stress in neurodegeneration. Genetic and pharmacological manipulation of antioxidant defense mechanisms significantly modified neurodegeneration in our model, suggesting that oxidative stress plays a causal role in neurotoxicity. …”

Peroxisome proliferator-activated receptor-γ cofactors in neurodegeneration by Katsouri, L, Blondrath, K, Sastre, M

“…In this review, we aim to analyze the role of the main regulators of PPARγ in the brain and during neurodegeneration.…”

The periaqueductal grey area and control of blood pressure in neurodegeneration by Sitsapesan, H, Green, A, Aziz, T, Pereira, E

Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex by Yates, R, Esiri, M, Palace, J, Jacobs, B, Perera, R, De Luca, G

“…The aim of this study was to investigate the extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relationship with neurodegeneration. METHODS: A post-mortem cohort of pathologically confirmed MS (n=47) and control (n=10) cases was used. …”

CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease by Delvenne, A, Gobom, J, Schindler, SE, Kate, MT, Reus, LM, Dobricic, V, Tijms, BM, Benzinger, TLS, Cruchaga, C, Teunissen, CE, Ramakers, I, Martinez‐Lage, P, Tainta, M, Vandenberghe, R, Schaeverbeke, J, Engelborghs, S, Roeck, ED, Popp, J, Peyratout, G, Tsolaki, M, Freund‐Levi, Y, Lovestone, S, Streffer, J, Barkhof, F

“…INTRODUCTION: We aimed to unravel the underlying pathophysiology of the neurodegeneration (N) markers neurogranin (Ng), neurofilament light (NfL), and hippocampal volume (HCV), in Alzheimer's disease (AD) using cerebrospinal fluid (CSF) proteomics. …”

The periaqueductal grey area and control of blood pressure in neurodegeneration. by Sitsapesan, H, Green, A, Aziz, T, Pereira, E

Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis? by Turner, M, Kiernan, M

Mouse models of neurodegeneration: Know your question, know your mouse by Fisher, E, Bannerman, D

Braiding Braak and Braak: staging patterns and model selection in network neurodegeneration by Putra, P, Thompson, TB, Chaggar, P, Goriely, A

Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. by Oliver, P, Finelli, M, Edwards, B, Bitoun, E, Butts, D, Becker, E, Cheeseman, M, Davies, K, Davies, B

“…Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Oxr1) as a vital protein that controls the sensitivity of neuronal cells to oxidative stress; mice lacking Oxr1 display cerebellar neurodegeneration, and neurons are less susceptible to exogenous stress when the gene is over-expressed. …”