Rescuing the Zygote Argument by De Marco, G

“…In a recent paper, Kristin Mickelson argues that Alfred Mele’s Zygote Argument, a popular argument for the claim that the truth of determinism would preclude free action or moral responsibility, is not valid. …”

Increasing knock-in efficiency in mouse zygotes by transient hypothermia by Bouchareb, A, Biggs, D, Alghadban, S, Preece, C, Davies, B

“…Taken together, our data suggest that a transient cold shock could offer a simple and robust way to improve knock-in outcomes in both stem cells and zygotes. …”

Dynamic shapes of the zygote and two-cell mouse and human by Graham, CF, Windsor, S, Ajduk, A, Trinh, T, Vincent, A, Jones, C, Coward, K, Kalsi, D, Zernicka-Goetz, M, Swann, K, Thomas, ALR

“…Mouse zygote morphokinetics were measured during interphase, the mitotic period, cytokinesis, and two-cell stage. …”

An investigation of the origin and significance of bilateral symmetry of the pronuclear zygote in the mouse. by Gardner, R, Davies, T

“…BACKGROUND: Preliminary observations revealed that advanced zygotes of the PO strain mouse are often bilaterally symmetrical, and suggested that both the plane of first cleavage and features of the blastocyst bear a consistent relationship to the zygote's bilateral plane. …”

Review of: Roe, Peter G.: The Cosmic Zygote: Cosmology in the Amazon Basin by Gray, A

Global changes of the RNA-bound proteome during thematernal-to-zygotic transition in Drosophila by Castello Palomares, A, Sysoev, V, Sysoev, V, Fischer, B, Frese, C, Gupta, I, Krijgsveld, J, Hentze, M, Ephrussi, A

“…The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the earliest developmental stages, during which maternally deposited mRNAs and other molecules are degraded and replaced by products of the zygotic genome. …”

Global changes of the RNA-bound proteome during thematernal-to-zygotic transition in Drosophila by Castello Palomares, A, Sysoev, V, Fischer, B, Frese, C, Gupta, I, Krijgsveld, J, Hentze, M, Ephrussi, A

“…The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the earliest developmental stages, during which maternally deposited mRNAs and other molecules are degraded and replaced by products of the zygotic genome. …”

Plasmodium berghei: routine production of pure gametocytes, extracellular gametes, zygotes, and ookinetes. by Rodríguez, M, Margos, G, Compton, H, Ku, M, Lanz, H, Rodríguez, M, Sinden, R

Monozygotic twin discordance for phacomatosis cesioflammea further supports the post-zygotic mutation hypothesis. by Castori, M, Sarazani, S, Binni, F, Pezzella, F, Cruciani, G, Grammatico, P

“…This report confirms that PPV likely originates from a post-zygotic mutation rising shortly after conception and affecting different cell lineages. …”

Intrinsic pre-zygotic reproductive isolation of distantly related pea aphid host races by Fazalova, V, Nevado, B, McLean, A, Godfray, C

Maternal supply of Cas9 to zygotes facilitates the efficient generation of site-specific mutant mouse models by Cebrian-Serrano, A, Zha, S, Hanssen, L, Biggs, D, Preece, C, Davies, B

Subjects:

Zygotic nucleosome assembly protein-like 1 has a specific, non-cell autonomous role in hematopoiesis. by Abu-Daya, A, Steer, WM, Trollope, A, Friedeberg, C, Patient, R, Thorne, A, Guille, M

“…Here, we report that depletion of zygotic xNAP1L in embryos produces no obvious morphologic phenotype, but ablates alpha-globin mRNA expression in the VBIs. …”

Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development. by Lal, K, Delves, M, Bromley, E, Wastling, J, Tomley, F, Sinden, R

“…The retort stage ookinete develops from the zygote by increasing growth of an apical protrusion and MDV-1 locates at the 'leading' extracellular apical pole of this protrusion. …”

Electroporation and genetic supply of Cas9 increase the generation efficiency of CRISPR/Cas9 knock-in alleles in C57BL/6J mouse zygotes by Alghadban, S, Bouchareb, A, Hinch, R, Hernandez-Pliego, P, Biggs, D, Preece, C, Davies, B

“…CRISPR/Cas9 machinery delivered as ribonucleoprotein (RNP) to the zygote has become a standard tool for the development of genetically modified mouse models. …”

The basis and significance of pre-patterning in mammals. by Gardner, R, Davies, T

“…The second polar body (Pb) provides an enduring marker of the animal pole of the zygote, thereby revealing that the axis of bilateral symmetry of the early blastocyst is aligned with the zygote's animal-vegetal axis. …”

Characterisation and expression of pbs25, a sexual and sporogonic stage specific protein of Plasmodium berghei. by del Carmen Rodriguez, M, Gerold, P, Dessens, J, Kurtenbach, K, Schwartz, RT, Sinden, R, Margos, G

“…Following gametogenesis and fertilisation in the bloodmeal within the mosquito midgut, the newly formed zygotes of the malaria parasite develop into motile invasive ookinetes. …”

A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion. by Guttery, D, Poulin, B, Ferguson, D, Szöőr, B, Wickstead, B, Carroll, P, Ramakrishnan, C, Brady, D, Patzewitz, E, Straschil, U, Solyakov, L, Green, J, Sinden, R, Tobin, AB, Holder, A, Tewari, R

“…Finally, increased mRNA expression of dozi, a RNA helicase vital to zygote development was observed in ppkl(-) mutants, with global phosphorylation studies of ookinete differentiation from 1.5-24 h post-fertilisation indicating major changes in the first hours of zygote development. …”

Plant evolution: TALES of development. by Dolan, L

“…Now, Lee et al. (2008) report that two TALE homeodomain proteins control zygote development of the unicellular green alga Chlamydomonas. …”

The evolutionary ecology of pre- and post-meiotic sperm senescence. by Pizzari, T, Dean, R, Pacey, A, Moore, H, Bonsall, M

“…We clarify different mechanisms of sperm senescence, outlining their distinct evolutionary implications for the male, the female and the zygote, and their influence on fundamental evolutionary processes, including the evolution of anisogamy, sexual conflict, sexual selection, and applied issues such as assisted conception.…”

An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission. by Patzewitz, E, Guttery, D, Poulin, B, Ramakrishnan, C, Ferguson, D, Wall, R, Brady, D, Holder, A, Szöőr, B, Tewari, R

“…SHLP1 is abundant in asexual blood stages and expressed at all stages of the parasite life cycle. shlp1 deletion results in a reduction in ookinete (zygote) development, microneme formation, and complete ablation of oocyst formation, thereby blocking parasite transmission. …”