Xanthones from Garcinia Malaccencis improve Glut4 aswell as decreased Pparγ activation on adipocytes by Bakhtiar, M. Taher, Mohamed Amiroudine, Mohamed Zaffar Ali, Darnis, Deny Susanti, Ichwan, Solachuddin J. A.

“…At the same time, induction of glucose uptake by α-mangostin and β-mangostin was accompanied by the increased mRNA expression of glut4 genes. Since downregulation of pparγ has been reported to be activated during inhibition of adipogenesis and enhance expression of glut4 has been shown to be increased during glucose uptake we demonstrated that both compounds follow the antiobesity pathways. …”
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Antiobesity effects of α-mangostin through glut4 and leptin expression together with pparγ activation in adipocytes by Bakhtiar, M. Taher, Mohamed Amiroudine, Mohamed Zaffar Ali, Darnis, Deny Susanti, Arief Ichwan, Solachuddin Jauhari, Kaderi, Mohd Arifin

“…At the same time, induction of glucose uptake and free fatty acid release by α-mangostin was accompanied by the increased mRNA expression of glut4 and leptin genes. As a result, we demonstrated that α-mangostin reduce lipid accumulation with decreased pparγ expression as well as stimulate the glucose uptake and free fatty acid release from the cells via glut4 and leptin expression. …”
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Insulin mimicking activities of Cycloartane Triterpenoid in 3T3-L1 cells by Bakhtiar, M. Taher, Mohamed Amiroudine, Mohamed Zaffar Ali, Darnis, Deny Susanti, Ichwan, Solachuddin J. A., Kaderi, Mohd Arifin

“…Further evaluation with the quantitative real time polymerase chain reaction (qRT-PCR) shows that mature 3T3-L1 cells treated with cycloart-24-en-3β-ol enhance pparγ and glut4 gene expression. As a result, it demonstrated that cycloartane triterpenoids enhance pparγ and glut4 gene expression. …”
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Cinnamtannin B1: a small compound having antidiabetes properties by Bakhtiar, M. Taher, Abdul Majid, Fadzilah Adibah, Sarmidi, Mohamad Roji

“…It acted directly on insulin receptor -subunit by activation of PI3-kinase that stimulates glucose transporter-4 (GLUT-4) translocation. Stimulation of GLUT4 translocation therefore stimulates glucose uptake lead to glucose disposal process in adipocytes. …”
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α-Mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells by Mohamed Amiroudine, Mohamed Zaffar Ali, Bakhtiar, M. Taher, Darnis, Deny Susanti, Arief Ichwan, Solachuddin Jauhari, Kaderi, Mohd Arifin, Zakaria, Zainul Amiruddin

“…The induction of glucose uptake and free fatty acid release by α-mangostin were accompanied by increasing mRNA expression of GLUT4 and leptin. In summary, these evidences proposed that α-mangostin might be beneficial for obesity management. …”
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