miMeasure – a standard for miRNA binding site characterization in mammalian cells by Adlung, Lorenz, Sabah, Jude Al, Bayer, Philipp, Berrens, Rebecca, Cristiano, Elena, Flocke, Lea, Kleinsorg, Stefan, Kolodziejczyk, Aleksandra, Kraemer, Stephen, Torre, Alejandro Macias, Mathur, Aastha, Mayilo, Dmytro, Neumann, Stefan, Niopek, Dominik, Pisa, Rudolf, Schad, Jan-Ulrich, Schumacher, Laura-Nadine, Uhlig, Thomas, Wu, Xiaoting, Keienburg, Jens, Boerner, Kathleen, Grimm, Dirk, Eils, Roland

“…We recommend a new standard unit, RKDU (relative knock-down unit) to describe the knock-down efficiency of a miRNA-BS in a specific cell type. pSMB_miMeasure allows for an easy and fast measurement of RKDU while providing effective normalization against variance stemming from differences in transfection efficiency and from other sources.…”
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Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action - Extended Version by Al-Radhawi, M. Ali, Manoj, Krishna, Jatkar, Dhruv D., Duvall, Alon, Del Vecchio, Domitilla, Sontag, Eduardo D.

“…In the context of epigenetic transformations in cancer metastasis, a puzzling effect was recently discovered, in which the elimination (knock-out) of an activating regulatory element leads to increased (rather than decreased) activity of the element being regulated. …”
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