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Radiation-induced inflammatory responses in carcinogenesis and cardiac disease
Published 2022Thesis -
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Hydrogen Sulfide (H2S) as a regulator of myocardial redox state and the redox-sensitive regulation of cystathionine γ-lyase (CSE)
Published 2017“…<p>In advanced stages, cardiac disease causes millions of deaths each year. Superoxide anions (O<sub>2</sub><sup>.…”
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3
Novel assessment of cardiorespiratory interactions in aortic stenosis
Published 2018“…On the contrary, those with a hyperdynamic right ventricle and apparent respiratory dysfunction determined by cardiac disease might avoid cardiac under-treatment.</p>…”
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4
THE INCIDENCE OF STROKE IN RSUP DR. SARDJITO IN THE YEAR OF 2012 AND 2013
Published 2014“…The risk factors that can lead to stroke are hypertension, cardiac disease, diabetes, hereditary, blood lipids, cholesterol, smoking, diet or obesity, soft water, race, age and gender. …”
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THE DIFFERENCE OF STROKE FACTOR BETWEEN PATIENT WHO LIVE IN RURAL AND URBAN AREA IN RSUP Dr. SARDJITO
Published 2014“…Some of the risk factors are hypertension, cardiac disease, diabetes, heredity, blood lipids, cholesterol, smoking, diet/obesity, soft water, race, age, gender, haematocrit, and oral contraceptives. …”
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6
Quantifying regional left ventricular function using spatio-temporal tracking techniques
Published 1999“…<p>Increasingly, diagnosis of cardiac disease, relies on computer processing of images to aid decision making. …”
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7
Investigating a novel catecholamine-associated cardiomyocyte subpopulation
Published 2021“…Excessive sympathetic stimulation of the heart, via catecholamines, is involved in a range of cardiac disease, from takotsubo cardiomyopathy to heart failure. …”
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8
Bayesian inference and machine learning methods for the advanced analysis of electrocardiographic signals
Published 2021“…Both electrocardiography and imaging are used for the clinical diagnosis of cardiac disease. The integration of multimodal datasets through advanced computational methods could enable the development of the cardiac ‘digital twin’. …”
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9
Atrial Fibrillation: unravelling the significance of lysosomes in atria under normal and pathological conditions
Published 2021“…They also play roles in signalling relevant to cardiac function and cardiac disease, however, the extent of altered lysosomal function in Atrial fibrillation (AF) is unknown. …”
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10
Development of proton magnetic resonance spectroscopy in human heart at 3 Tesla
Published 2010“…Different MRI sequences are routinely used to assess cardiac anatomy, function, viability and other parameters that aid diagnosing cardiac disease. Conversely, cardiac magnetic resonance spectroscopy (MRS), the only available method for a non-invasive study of human cardiac metabolism, has not evolved into a clinical tool yet. …”
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11
The roles played by the transcriptional regulators PPARalpha, HIF-1alpha and SIRT1 in the control of cardiac metabolism
Published 2014“…The results presented here increase knowledge of cardiac transcriptional regulation, which is important for our understanding of how manipulating cardiac metabolism may enable the development of therapies to improve energy metabolism in cardiac disease states.</p>…”
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12
Investigation into pathophysiological mechanisms that alter ryanodine receptor function in cardiovascular disease
Published 2020“…<p>Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is a highly malignant cardiac disease caused by mutations to the cardiac ryanodine receptor (RyR2). …”
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13
The role of adenosine A2A receptor signalling in cardiac fibrosis
Published 2015“…A2AR manipulation may contribute to further understanding of pathophysiological pathways in the development and progression of cardiac disease and represents an excellent therapeutic target for clinically available A2AR antagonists.…”
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14
Altered contractile mechanics and Ca2+ handling contribute to cardiomyopathy pathogenesis
Published 2015“…<p>Mutations in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopathies. However, cardiac disease caused by mutations in non-sarcomeric proteins exhibit remarkably similar phenotypes, suggesting that common modes of pathogenesis might exist. …”
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15
Investigating cardiac metabolism and the effect of novel metabolic modulation therapy on cardiac physiology and exercise capacity in aortic stenosis: a multi-parametric cardiac mag...
Published 2023“…Moreover, these patients though able to exercise to volitional exhaustion without developing symptoms have reduced average peak VO2 and VE/VCO2, both of which are predictors of outcome in cardiac disease.</p> <p>In Chapter 4 and 5, the effect of the PPARa agonist Fenofibrate was evaluated on cardiac metabolism and physiology in a randomised double-blind placebo-controlled study. …”
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16
Anticancer Activities of Extracts and Purified Compounds from Jeruju Putih (Acanthus Ilicifolius L.)
Published 2007“…Currently, cancer is Malaysia’s number two killer only preceded by cardiac disease. Unfortunately, there is no effective cure for the disease has yet to be discovered. …”
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17
The effects of obesity and weight loss in heart failure: imaging the obesity paradox using magnetic resonance imaging and spectroscopy
Published 2018“…I investigated this question in obese individuals without additional cardiac disease, and found not only that the reaction rate of creatine kinase was elevated, maintaining ATP delivery at rest, but that the enzyme reaction rate response to catecholamine stress was blunted, yielding no increase in energy delivery despite increased workload. …”
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18
Fluid dynamics of the human aortic valve
Published 2008“…In the recent decades it has been renowned that cardiac diseases are the most deadly diseases throughout the world and of that the diseases pertaining to the valves are proportionately low but are significantly higher in number. …”
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19
Application of deep learning algorithms for automated detection of arrhythmias with ECG beats
Published 2019“…Prolong arrhythmias are life threatening and can often lead to other cardiac diseases. Abnormalities in the conduction system is reflected upon the morphology of the electrocardiographic (ECG) signal and the assessment of these signal can be extremely challenging and time-consuming. …”
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