Image guidance in cardiac electrophysiology by Malchano, Zachary John

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A comparison of discrete and continuum models of cardiac electrophysiology by Bruce, D

Subjects: “…Cardiac Electrophysiology…”

Incorporating inter-sample variability into cardiac electrophysiology simulations by Walmsley, J

Model-driven design and uncertainty quantification for cardiac electrophysiology experiments by Lei, CL

“…Mathematical modelling and computational simulation has been a crucial tool for basic research in cardiac electrophysiology for decades, and has provided remarkable insights into many physiological mechanisms. …”

Utility and limitations of cardiac tissue slices for the study of cardiac electrophysiology by Wang, K

“…</p> <p>We conclude that the cardiac tissue slice preparation preserves some key functional parameters of the whole heart and is a promising model to study cardiac electrophysiology.</p> …”

Combined experimental and computational investigation into inter-subject variability in cardiac electrophysiology by Britton, O

Subjects: “…Cardiac electrophysiology…”

Optimal control based on nonlinear conjugate gradient method in cardiac electrophysiology by Ng, Kin Wei

“…Consequently, this leads to an optimization problem arising from cardiac electrophysiology, namely Optimal Control Problem of Monodomain Model (OCPMM). …”
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A multi-scale computational investigation of cardiac electrophysiology and arrhythmias in acute ischaemia by Dutta, S

Computational methods for the estimation of cardiac electrophysiological conduction parameters in a patient specific setting by Wallman, K

Mathematical modelling of drug-ion channel interactions for cardiac safety assessment by Beattie, K

Subjects:

A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype by Ahmad, F

Subjects:

Modelling of calcium handling in genetically modified mice by Li, L

“…In Chapter 1, with emphasis on calcium dynamics and calcium regulation in heart failure, an overview of cardiac electrophysiology, excitation-contraction coupling and mathematical models of cardiac electrophysiology is provided. …”

In silico investigations into human ventricular pro-arrhythmic mechanisms combined with in vivo and in vitro experiments by Zhou, X

“…</p> <p>In this thesis, we use biophysically-detailed models of human cardiac electrophysiology to explore the ionic mechanisms underlying several proarrhythmic conditions. …”

Automatic simplification of differential equation models by a posteriori analysis by Maybank, P

“…The method is used to automatically simplify several differential equation models including models of chemotaxis and tissue-level cardiac electrophysiology.</p>…”

Bayesian inference for biological time series by Creswell, R

“…We motivate our methodological innovation by a comprehensive examination of the biases in inference that result from insufficiently accurate numerical approximation of differential equations, as well as time series inverse problems and models drawn from epidemiology, hydrology, and cardiac electrophysiology.</p>…”

Uncertainty characterisation in action potential modelling for cardiac drug safety by Johnstone, R

“…The CiPA initiative aims to replace the TQT study with a combination of in-vitro ion channel screening and mathematical mechanistic models of single-cell cardiac electrophysiology to predict a drug's proarrhythmic risk. …”

The cardiac L-type calcium current: existing models and methods of improvement by Agrawal, A

“…Arrhythmias can be initiated by unintended modulations of cardiac electrophysiology by pharmaceutical drugs. Therefore, in the past decade, drug regulatory bodies have implemented the use of cardiac models for cardiac safety assessment of novel drugs. …”

Investigations of electrophysiological mechanisms related to myocardial ischaemia in hypertrophic cardiomyopathy: implications for arrhythmic risk, ECG diagnosis, and antiarrhythmi... by Coleman, JA

“…Using multiscale modelling of cardiac electrophysiology, this thesis aimed to investigate the electrophysiological effects of myocardial ischaemia and ionic remodelling in HCM, to benefit arrhythmic risk predictions, the ECG diagnosis of ischaemia, and antiarrhythmic therapy.…”

An open source HPC-enabled model of cardiac defibrillation of the human heart by Bernabeu Llinares, M

“…The main reason is the large computational requirements associated with the solution of the bidomain equations of cardiac electrophysiology over large anatomically-accurate geometrical models including representation of fibre orientation and transmembrane kinetics.…”

Scalable multi-parametric imaging of excitable tissue by Lee, P

“…<p>The field of cardiac electrophysiological imaging has advanced tremendously in the past three decades with developments in fluorescent dyes, photodetectors, optical filters, illumination sources, computers and electronics. …”