An in vivo evaluation of aneuploid hematopoietic stem cell fitness by Pfau, Sarah Jeanne

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Dedifferentiation of hematopoietic stem cells into induced pluripotent stem cells by Monireh Soroush Noghabi

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Inducing expansion of hematopoietic stem cells by HMG box proteins by Loh, Shuzk Cheng

“…Hematopoietic stem cells (HSCs) are rare multipotent stem cells that give rise to all blood lineages, and its development is tightly regulated at all stages to ensure retention of full hematopoietic functionality throughout life. …”
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Maintenance and expansion of hematopoietic stem cells in vitro using genetic methods by Wu, Zhihao

“…Subsequent studies have shown that the ectopic expression of these leukemogenic or similar fusion genes in primitive bone marrow (BM) cells can induce hematopoietic stem cell (HSC) activity in these cells. We have extensively surveyed different branches of the homeodomain superfamily as partners to NUP98 in order to find fusion genes that could sustain HSC activity in BM cells in long-term continually expanding in vitro cultures. …”
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Transgene Silencing Following Lentiviral Gene Delivery into Hematopoietic Stem Cells by Ngai, Siew Chang

“…Unlike other viral methods, lentiviral vectors (LVs) are attractive gene transfer vehicles due to their ability to transduce non-dividing cells such as hematopoietic stem cells (HSCs) efficiently. The objectives of this study are to evaluate if the HSCs transduced by LV are subject to transgene silencing, and to determine the factors that contribute to this event. …”
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Mitogenic activity of mesenchymal stem cells on hematopoietic stem cells via cellular analysis and gene expression by Mohadeseh, Hashem Boroojerdi

“…Introduction: During the last three decades, hematopoietic stem cell (HSC) transplantation has become a well-established treatment for many hematologic malignancies and deficiencies. …”
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Effects of mild gestational diabetes mellitus on quality of umbilical cord blood hematopoietic stem cells procured at delivery by Ahmed, Sara. M.El.

Subjects: “…Hematopoietic Stem Cells…”
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Investigation of a suppression of asymmetric cell kinetics (SACK) approach for ex vivo expansion of human hematopoietic stem cells by Taghizadeh, Rouzbeh R

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The impact of ageing on the human haematopoietic stem cell and memory T cell compartments through the lens of single cell transcriptome analysis by Gafencu, GA

Subjects: “…Hematopoietic stem cells…”

RUNX1 cis-regulation and effector function during human endothelial-to-haematopoietic transition by Cavallo, A

Subjects: “…Hematopoietic stem cells…”

Harnessing the graft-versus-leukaemia effect in acute myeloid leukaemia by Sweeney, C

Subjects:

Towards an engineered autologous cellular therapy for RAG2 deficiency by Gardner, CL

“…Unless treated with a hematopoietic stem cell transplantation (HSCT), RAG deficient patients succumb to severe infections early in life. …”

Locus-wide studies into the transcriptional regulation of Runx1 in developmental hematopoiesis by Jarratt, A

“…The founding cell of definitive hematopoiesis, the hematopoietic stem cell (HSC), gives rise to all adult blood lineages throughout the life span of an organism. …”

Unravelling haematopoietic stem cell dysfunction in isolated Del(5q) myelodysplastic syndromes by Stenson, L

“…</p> <p>The 5q deletion originates in the Hematopoietic Stem Cell (HSC) compartment and Del(5q) HSCs have a clonal advantage, outcompeting healthy HSCs in the bone marrow of patients. …”

Modulation of immune cell niches for therapeutics in cancer and inflammatory diseases by Fewkes, N, Natasha Fewkes

“…Sunitinib inhibits multiple tyrosine kinases including KIT, an essential survival signal within the hematopoietic stem cell and thymic progenitor niches. Sunitinib therapy diminishes hematopoietic and thymic progenitor cells in mice and enhances accessibility of marrow and thymic niches to transplanted bone marrow. …”

Hyperglycaemia induced immunomodulation of macrophages in diabetic vascular disease by Edgar, L

“…</p> <p>Methods and Results: Hyperglycaemia alters monocyte, macrophage and hematopoietic stem cell (HSC) metabolism, significantly increasing glycolysis (FDR=0.02, human monocyte non-targeted metabolomics screen). …”

Non-viral transfection of bone marrow-derived mesenchymal stem cell with human interferon-gamma gene and in vitro efficiency against chronic myeloid leukaemia cells by Liew, Lee Chuen

“…Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder caused by the BCR/ABL gene rearrangement, known as the Philadelphia (Ph) chromosome. …”
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Generation and validation of Aspergillus fumigatus monoclonal antibodies by Jafarlou, Mahdi

“…People at high risk for aspergillosis include patients with advanced AIDS, prolonged neutropenia, allogeneic hematopoietic stem cell transplant recipients, solid organ transplant recipients, and chronic granulomatous disease. …”
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Clinical evaluation and proteomic profiles of acute myeloid leukemia patients, Saudi Arabia by Almaiman, Amer Abdulrahman

“…Acute myeloid leukemia (AML) represents a group of clonal hematopoietic stem cell disorders which fail to differentiate and proliferate result in the accumulation of nonfunctional myeloblasts. …”
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A pilot study on Pedsql™ modul impak keluarga among caregivers of children with transfusion dependant thalassaemia in Hospital USM, Malaysia by Tan, Suria Emilia Suhana Othman

“…Currently, only successful hematopoietic stem cell transplant (HSCT) can offer a permanent cure but it is limited by HLA-matched sibling donor and procedure related complication (Cheuk et al., 2008). …”
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