Molecular responses of iron regulatory proteins to iron overload in human liver by Neonaki, Maria

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Mechanisms underlying the efficacy of normothermic machine perfusion in human liver transplantation by Nasralla, D

“…Herein is reported the first randomised controlled trial (RCT) comparing continuous NMP with SCS in human liver transplantation. Additional work exploring the mechanisms behind the effects of NMP is also described.…”

Accurate and precise 3D T1 mapping of the human liver at 3T using widely available magnetic resonance imaging methods by De Matos Gomes Belsley, G

Engineering human hepatic tissue for modeling liver-stage malaria by Ng, Shengyong

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Andrographis Paniculata And Curcuma Xanthorrhiza Extracts And Active Constituents Inhibit Morphine Glucuronidation by Husni, Zulhilmi

“…The inhibitory effects of selected Malaysian medicinal plant herbs namely Andrographis paniculata and Curcuma xanthorrhiza on morphine glucuronidation were evaluated on recombinant UGT2B7 protein and human liver microsomes. Ethanolic and aqueous extracts of Andrographis paniculata as well as andrographolide inhibited morphine glucuronidation at various degrees except for neoandrographolide. …”
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Adaptive abdominal fat and liver segmentation of ct scan images for abdominal fat-fatty liver correlation by Mharrib, Ahmed M.

“…This study aims to investigate the strength and the type of correlation between the indexes of abdominal fat and the level of diffused fat in human liver. Adaptive methods for abdominal fat segmentation and human liver segmentation using CT images are proposed. …”
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Building blocks for regenerative medicine : vascularized models and immunomodulation to engineer hepatic cell therapies by Chhabra, Arnav.

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A microfabricated 3D tissue engineered "Liver on a Chip" : information content assays for in vitro drug metabolism studies by Sivaraman, Anand, 1977-

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Effects of thymoquinone and thymoquinone-loaded nanostructured lipid carrier on hepatocellular carcinoma cell models, Hep3B and HepG2 by Haron, Aminah Suhaila

“…TQ or TQ-NLC inhibited the growth of both models of human liver cancer cells. The IC50 obtained for Hep3B treated TQ or TQ-NLC at 24 hours was 16.7±2.86 μM and 13.5±3.58 μM respectively. …”
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Unravelling the role of AKR1D1 in human hepatocytes by Nikolaou, N

“…Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyses a fundamental step in bile acid synthesis. …”

Effects Of Chrysin On The mRNA Expression Of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) And Cyp Genes, Cell Cycle And Cell Migration In Colorectal Cancer Hct-116 Cell... by Khor, Chin Yin

“…Peroxisome proliferator-activated receptor-alpha (PPARα) is reported to regulate the transcription of cytochrome P450 genes in human liver and intestine, which accounts for 70-80% of the enzymes involved in drug metabolism. …”
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Proteomic profiling of metastatic matrisome reveals citrullination as a marker of colorectal liver metastasis by Yuzhalin, A

“…PAD4, a key enzyme responsible for catalysing citrullination, is produced by metastatic colorectal cancer cells and found at higher levels in human liver metastases than in normal liver. Functional significance for citrullination in metastatic growth was evident in murine models where inhibition of citrullination, either globally by pharmacologic inhibition of PADs or specifically in colorectal cancer cells by PAD4 knockdown reduced liver metastatic burden by 3- to 4-fold (P < 0.05). …”

Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes by Osman, Md.Uwaisulqarni

“…Cytotoxic screening was carried out against Human ovarian cancer cells (CaOV-3), Human breast carcinoma cells with negative estrogen receptor (MDA-MB-231) and Human liver carcinoma cells (HEP-G2). Antimicrobial screening was carried out against four bacteria and three fungi. …”
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Synthesis of polyfunctionalised cyclopentanes by Hui, A, Hui, Andrew W.H.

“…The inhibitory activities of the amino pentol and the spirohydantoin against human liver glycosidases are reported.</em.r<></em></p> <p>The azido bicyclic lactone triol (1<em>R</em>,4<em>S</em>,5<em>R</em>,6<em>R</em>,7<em>R</em>)-4-azido-5,6,7-trihydroxy-2-oxabicyclo[ 2.2.1]heptan-3-one underwent reduction of the azide functionality with concomitant epimerisation to give the (5<em>S</em>)-epimeric amine. …”

Antiproliferative Properties Of Clitoria Ternatea And Vitex Negundo On Cancer Cell Lines by Dashti, Neda Ganjali

“…The major aim of this study was to examine the anti-proliferative activities (IC50 value <100 μg/mL) of water and methanol extracts of both plants against human cancer origin cell lines, namely MCF-7 (hormone-dependent breast cancer cell line), MDA-MB-231 (non-hormone-dependent breast cancer cell line), Caov-3 (human ovary cancer cell line), Hela (human cervical cancer cell line), HepG2 (human liver cancer cell line) and Hs27 (human non-cancer-origin fibroblast cell line). …”
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Proteomics-aided search for extracellular matrix signatures of colorectal hepatic metastases ex vivo by Yuzhalin, A

“…We next confirmed by immunohistochemistry that annexin A1 is markedly overexpressed in colorectal hepatic metastases, as well as in human liver metastases, as compared to adjacent healthy tissue. …”

Metabolic assessment of perfused livers using magnetic resonance imaging and spectroscopy by Young, LAJ

“…Then I assessed the ability of temperature-corrected MR techniques to assess organ viability in ex vivo human liver during the traditional preservation of static cold storage. …”

Immuno-molecular profiling and modulation of donor livers during normothermic machine perfusion by Dengu, F

“…Through an evaluation of samples from clinical trials of human liver perfusion, I have demonstrated that ex situ reperfusion injury/inflammation (ERI) is an immunologically and molecularly distinct entity observed consistently across livers preserved with NMP. …”

Human Hepatitis B Viral Proteins HBX and HBE: Roles in HepG2 Cell Line Survival and Cell Death by Holme, Andrea Lisa

“…The two main candidates for inducing survival changes were the precore proteins (HBE) and HBX, both of which have been reported to accumulate in the liver of patients and to trigger an immune response. The human liver HepG2 cell line was chosen to study the effect ,of these proteins during transient expression. …”
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Absolute quantification of human in vivo hepatic 31P magnetic resonance spectroscopy at 7 tesla by Purvis, L

“…</p> <p>A 3D chemical shift imaging method using a 16 channel ³¹P array at 7 T is chosen to give high SNR ³¹P spectra from the human liver in vivo, while also providing good spatial localization and spectral resolution.…”