Regulation of biochemical pathways involved in neurodegeneration by Pooler, Amy Melissa

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A magnetic resonance approach to neurodegeneration by Chen, Yin-Ching Iris

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Molecular Profiling and Mechanisms of Cerebrovascular Function in Health and Neurodegeneration by Garcia, Francisco J.

“…Furthermore, the presence of a bloodbrain barrier (BBB) provides protection to vulnerable neurons but poses a challenge for drug delivery. In neurodegeneration, BBB breakdown and vascular impairments are hallmarks that precede the onset of disease-specific phenotypes. …”
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Investigating the role of alternative polyadenylation in neuronal differentiation and neurodegeneration by Patel, R

“…Using a combination of molecular biology and bioinformatics approaches, this thesis assesses changes in APA profiles regulated by transcriptional and post-transcriptional APA during neuronal differentiation, in neurodegeneration and in cellular stress. The BE(2)-M17 neuroblastoma cell line was used to model neuronal differentiation. …”

The deubiquitylase TRABID coordinates sex-specific neurodegeneration in drosophila melanogaster by Xia, J

“…However, sex differences are widely observed in both inflammation as well as neurodegeneration phenotypes. In this study, I investigated sex dimorphism, in ubiquitination at the intersection of inflammation and neurodegeneration. …”

Analysis of novel pathways in neurodegeneration using mouse and fly model organisms by Paton, L

“…Histological analysis of the brain revealed for the first time progressive neurodegeneration in the cerebellum with severe Purkinje cell loss. …”

Developing neuroimaging biomarkers for neurodegeneration and ageing using machine learning methods by Arya, Z

“…</p> <br/> <p>Ageing is strongly linked with neurodegeneration. Hence, the second method is an errors-in-variables model for estimating the brain age of individuals. …”

Neurodegeneration and brain cancer: a longitudinal field study of rest-activity and sleep by Wams, E

“…<p>This thesis investigates rest-activity and sleep profiles in neurodegeneration and brain cancer. Study 1 comprised longitudinal field assessments of rest-activity, sleep and memory in controls and memory-impairment individuals with: subjective memory complaint (SMC), amnestic mild cognitive impairment (aMCI), mild and moderate Alzheimer’s disease (AD). …”

The role of the cdk5 pathway and NMDA receptor phosphorylation in neurodegeneration in hippocampal sclerosis by Falah, M

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

Subjects: “…neurodegeneration…”

Clinical and neuroimaging markers of prodromal neurodegeneration in rapid eye movement sleep behaviour disorder by Barber, TR

“…Overall, our data indicate that RBD patients have extensive evidence of underlying neurodegeneration, which manifests as a clinical phenotype with unique characteristics, suggesting that RBD may represent the prodromal phase of a particular synucleinopathy subtype. …”

In Vitro And In Vivo Study On The Identification Of Compounds That Alleviate Aβ42 Associated Neurodegeneration by Tan, Florence Hui Ping

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Using network inference to discover molecular pathways underlying cytokine synergism and age-related neurodegeneration by Hwang, Bryce

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An integrative approach to profiling the central nervous system by Grant-Peters, M

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Selective vulnerability of the primary motor cortex in amyotrophic lateral sclerosis by Nolan, M

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Investigating TDP43 biological dysfunction through the characterisation of Tardbp ENU mouse mutants: implications for neurodegeneration by De Sao Jose Martinho De Oliveira, H, Hugo De Sao Jose Martinho De Oliveira

“…</p> <p>Mechanistic dissection between TDP43 dysfunction and downstream neurodegeneration has remained elusive given that both over-expressor cellular and mouse models and conditional deletion or knockdown models have been shown to develop behavioural dysfunction and, in some cases, neurodegeneration with associated dysfunction in RNA metabolism.…”

Development and application of image analysis techniques to study structural and metabolic neurodegeneration in the human hippocampus using MRI and PET by Bishop, CA

Characterisation of tualang honey silver nanoparticles (THSN) and neuroprotective effect of tualang Honey and thsn on kainic acid-induced neurodegeneration in male rats’ hippocampus by Hasim, Hidani

“…Neurodegeneration is a feature of many chronic disorders of the central nervous system that result in the deterioration of neuronal structure and function. …”
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Creating and characterising physiological mouse models of SOD1- and C9orf72-ALS by Thompson, D

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Molecular mechanisms underlying haplotypespecific regulation of gene expression at the microtubule associated protein tau locus by Lai, MC

Subjects: “…molecular neurodegeneration…”