The influence of body composition and fluid volume distribution on renal and cognitive functions in middle-aged and older patients with type 2 diabetes mellitus by Low, Serena Kiat Mun

“…Aim: The aim of the thesis was to investigate the associations between body composition with renal and cognitive function in T2DM, and the association between water balance with renal and cognitive function in T2DM. …”
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A novel shock wave lithotripsy system by Wang, Jen-Chieh

“…Furthermore, retreatment, remained stone fragments, and renal injury are commonly observed in clinical shock wave lithotripsy. …”
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Using organoid xenograft model of PKD to validate novel pathological pathways revealed by single cell analysis by Zhang, Tian

“…PKD is a major global health concern, contributing significantly to end-stage renal disease. Current therapeutic challenges in PKD stem from its complex pathogenesis, requiring extensive research to identify effective targets and unravel signaling networks. …”
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Modelling genetic polycystic kidney disease using human pluripotent stem cell-derived kidney organoids by Liu, Meng

“…Patient iPSC-derived kidney organoids developed tubular cysts in vivo upon engraftment into the sub-renal capsule space of immunocompromised mice. We also performed a small-scale drug screening and identified two candidate drugs that can effectively attenuate cyst formation in both ARPKD and ADPKD kidney organoids. …”
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Art of tumor immunity: extricating hypoxia-driven immunosuppression in the solid tumor microenvironment by Tay, Apple Hui Min

“…With cytotoxic T cells and natural killer (NK) cells being the two main effector cytotoxic cells, Paper I examined how targeting the adenosine (ADO) signaling axis via adenosine-2B receptor (A2BR) restore T cell function and Paper II investigated the influence of pseudohypoxia on NK cells using clear cell renal cell carcinoma (ccRCC) with von Hippel-Lindau (VHL) mutation. …”
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Exploiting reductive evolution in Mycobacterium ulcerans to develop a single-dose cure for Buruli ulcer by Sangeeta, Susan Thomas

“…Moreover, drug toxicity issues such as ototoxicity and renal failure make the treatment regimen very difficult to follow through for the patients. …”
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Semiconducting polymer nanoparticles for multimodal biophotonics by Jiang, Yuyan

“…As such, these NIR-II PA nanoagents can be effectively cleared out via both hepatobiliary and renal excretions after systematic administration, leaving no toxicity to living mice. …”
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