Unravelling human embryonic macrophage development using single cell sequencing and induced pluripotent stem cell models by Lee, Christopher Zhe Wei

“…Traditional dogma dictates that resident tissue macrophages (RTMs) develop from bone marrow hematopoietic stem cell (HSC)-derived monocytes. However through the use of fate mapping in mouse models, we now understand that embryonic macrophages from a non HSC-derived source seed the developing organs, and in some tissues persist independently of the circulating adult monocyte population under steady state conditions. …”
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