Biodegradable synthetic macromolecules as anticancer therapeutics by Tay, Joyce Jia Xin

“…Lastly, this thesis concludes with an evaluation on the usage of synthetic polymeric nanoparticulate system as anticancer therapeutics and discusses possible strategies of using patient-derived cancer cell membrane to enhance selectivity and achieve personalized therapeutics.…”
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Therapeutics for enhanced chronic wound healing by Tan, Mandy Li Ling

“…The current results support the therapeutic potential of Cx43asODN in promoting chronic wound healing. …”
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Development of Staphylococcus aureus-derived skin cancer therapeutics by Ong, Zi Xin

“…As molecular targeted therapy increases in prominence, the search for novel cancer cell-specific therapeutic agents with low off-target effect continues. …”
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Microtissue-encapsulating devices for hypoxia reduction of cellular therapeutics in diabetes treatment by Chen, Yang

“…Overall, the results of this thesis showed that the adoption of toroidal geometry in the design of therapeutical microtissues probably enhances cell survival of cellular grafts. …”
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Understanding the molecular basis of flavivirus replication process for antiviral therapeutics development by Quek, Jun Ping

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Therapeutic targeting of NAMPT and its associated pathways in hepatocellular carcinoma by Yeo, Joanna Zhen Zhen

“…To uncover clinically relevant cancer-specific metabolic targets, patient derived HCC models were generated and subjected to a high throughput metabolic screening. This revealed therapeutic vulnerability of a subset of HCC towards NAD metabolism and circadian rhythm related pathways, which are commonly dysregulated pathways in HCC. …”
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Discovery of small molecule therapeutics for the Middle Eastern respiratory syndrome-coronavirus (MERS-CoV) by Gan, Jonathan Hanjie

“…Finally, validation studies on this potential therapeutic candidate were performed by employing live MERS-CoV. …”
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Development and evaluation of chemical modifications and conjugations for nucleic acid therapeutic delivery by Nguyen, Minh Duc

“…These findings may contribute to the knowledge of ASOs and siRNAs delivery methods and potentially facilitate the future development of these therapeutics.…”
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Nongenetic engineering of subcellular targeted therapeutic agents to facilitate precise cell activity manipulation by Do, Cong Thang

“…Precise cellular event manipulation is highly demanded in the current development of biomedical therapeutics. This direction requires highly interdisciplinary design systems that revolutionize cell fate regulation. …”
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Identification of molecular factors mediating therapeutic resistance in diffuse large B-cell lymphoma (DLBCL) by Peng, Chenchen

“…This revealed potential predictive biomarkers and therapeutic targets of JunD and STAT2 and their regulated genes. …”
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Synthesis of self-assembled organic-inorganic hybrid nanomaterials for cancer diagnostics and photo-induced therapeutic applications by Bindra, Anivind Kaur

“…Utilizing the organic component scaffolds as the carrier or direct therapeutic agent and inorganic nanoparticles as the imaging agents or the direct therapeutic agents, we could attain hybrid nanostructures that are biocompatible, stable, and highly efficient. …”
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Development of novel agonists for the orphan nuclear receptor, Nurr1 : a therapeutic strategy for Parkinson’s disease by Toh, Hui Ting

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Microneedle technology on dermatological application by Ning, Xiaoyu

“…Moreover, the therapeutics are in solid state after lyophilization, which further guaranteed their stability. …”
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Metal ions-based layer-by-layer coatings for antibacterial applications by Lim, Yun

“…The unique roles of metal ions as alternative antibacterial and antibiofilm therapeutics against Gram-positive and Gram-negative pathogens will subsequently be studied. …”
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Scaffold mediated delivery of drugs/genes for promoting nerve regeneration via gene silencing/pathway inhibition after traumatic nerve injuries by Zhang, Na

“…Consequently, the development of effective therapeutics, particularly targeting tissue regeneration, remains slow. …”
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OnionMHC: a deep learning model for peptide - HLA-A*02:01 binding predictions by Saxena, Shikhar

“…The model can be used in the screening of potential neo-epitopes for the development of cancer vaccines or designing peptides for peptide-based therapeutics.…”
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Development of Levodopa-loaded inhalable dry powders for treatment of Parkinson's disease via the pulmonary system by Paul, Mahasweta

“…In such a scenario, the therapeutic efficiency of pulmonary drug delivery of Levodopa might get affected due to entrapment of the drug particles by the mucus layer. …”
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Biophysical and structural characterization of nucleic acids: I. Structure, ions and folding/unfolding kinetics of left-handed G-quadruplexes II. Interaction of ligands with G-quad... by Das, Poulomi

“…G-quadruplexes are non-canonical structures of nucleic acid which has gained huge interest in the last few decades due to its crucial role in various biological processes, and for its applications as robust synthetic polymer in the field of therapeutics and nanotechnology. G-quadruplex structures are highly polymorphic and are able to modulate their structural characteristics depending on the environmental conditions. …”
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Biomimicking scaffolds for neural tissue regeneration and innate immunomodulation by Lin, Junquan

“…Besides surface modification, these electrospun synthetic fibers can also be assembled into a 3 dimensional (3D) scaffold which can delivery therapeutics in a sustained fashion when implanted into spinally injured rats. …”
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Understanding the viral protein structures of clinically relevant arboviruses and fragment-based screening for antivirals by Farhana Abu Bakar

“…To date, there are no specific therapeutics available to prevent or mitigate the disease. …”
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