Studies on the immunological mechanisms leading to protection or pathology during malaria infection by McGuire, Daniel Ribeiro da Silva

“…Despite decades of research and a multitude of immunization strategies we still have not been able to produce a safe and efficacious vaccine. Nevertheless, trials with the most advanced vaccine to date, RTS,S, have demonstrated that small, incremental iterations such as the use of ideal adjuvants, could significantly bolster the effectiveness of promising candidates. …”
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Computational modelling and data analysis on the virulence of influenza viruses by Zhou, Xinrui

“…However, the rapid and continuous evolution of influenza raises the challenge to prepare vaccine candidates matching the antigenicity of dominant circulating influenza viruses for the next season. …”
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Role of glycolysis in myeloid cells during dengue infection by Loy, Thomas

“…There is no dengue virus (DENV) specific treatment, while there are several issues with the current dengue vaccines. Amongst blood cells, monocytes are the main target of DENV and monocytes interact with non-structural 1 (NS1) protein via TLR2/TLR4/TLR6 that might contribute to pathogenesis by supporting DENV replication and secreting inflammatory cytokines. …”
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Development of viral surveillance for endemic disease, emerging viral characterization and zoonic spill-over spill-back models by Tan, Zi Hian

“…The dengue virus causes mostly subclinical infections; however, with as many as an estimated 300 million infections and 100million recorded dengue cases per year it brings about an economic and healthcare burden. As there is no vaccine available for the dengue virus, managing dengue infection relies solely on vector (mosquito) management. …”
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New antiviral therapies to treat zika infections : neutralizing monoclonal antibodies and inhibitors of interactions between non-structural proteins by Jia, Huan

“…Though the declaration was withdrawn in November 2016, there is still no antiviral drug or vaccine available for ZIKV and more research must be devoted to find therapies against ZIKV infection. …”
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Discovery of small molecule therapeutics for the Middle Eastern respiratory syndrome-coronavirus (MERS-CoV) by Gan, Jonathan Hanjie

“…As there are currently no specific vaccines and therapeutics for this viral infection, there is an unmet medical need to develop drugs against MERS-CoV infection. …”
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OnionMHC: a deep learning model for peptide - HLA-A*02:01 binding predictions by Saxena, Shikhar

“…The model can be used in the screening of potential neo-epitopes for the development of cancer vaccines or designing peptides for peptide-based therapeutics.…”
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Design, characterization, and application of antiviral agent screening platform by Park, Soo Hyun

“…Emerging and reemerging viral pathogens are a major global health problem, and specific therapies and vaccines are unavailable for the vast majority of viral pathogens. …”
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Identification and characterization of novel chemical scaffolds to overcome drug resistance in malaria by Tay, Donald Wen Jun

“…Without an efficacious vaccine, strong emphasis is placed on discovering and developing new chemotherapeutics with novel mechanisms of action to prevent and control malaria infections. …”
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Exploiting reductive evolution in Mycobacterium ulcerans to develop a single-dose cure for Buruli ulcer by Sangeeta, Susan Thomas

“…Following the effective implementation of the BCG vaccine and the rigorous and conscious effort taken globally to curb tuberculosis and leprosy, infections due to non-tuberculous mycobacteria (NTM) are now gaining prominence worldwide. …”
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Development of an oil-free swing vane compressor with liquid refrigerant injection by Heng, Kim Rui

“…The current refrigeration system that relies on oil-lubricated compressor is not feasible for applications such as wearable cryogenic cooling bags for the ease of vaccine transportation or compact cryogenic coolers for space applications. …”
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Could evaluation mode nudge people's health-related decisions? Extending the general evaluability theory to risk communication by Xu, Yihan

“…Study 2 investigates how the relative justifiability of costs affects laypeople’s evaluations of two flu vaccines, where they trade off costs (easy-to-evaluate) and chance of side effects (hard-to-evaluate). …”
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