Defensive marketing strategy in the prescription analgesic market by Beshel, Joseph J

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The Current and Potential Application of Medicinal Cannabis Products in Dentistry by Lowe, Henry, Toyang, Ngeh, Steele, Blair, Bryant, Joseph, Ngwa, Wilfred, Nedamat, Kaveh

“…Herbs have also been used as plaque removers (chew sticks), antimicrobials, analgesics, anti-inflammatory agents, and antiseptics. …”
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The Current and Potential Application of Medicinal Cannabis Products in Dentistry by Lowe, Henry, Toyang, Ngeh, Steele, Blair, Bryant, Joseph, Ngwa, Wilfred, Nedamat, Kaveh

“…Herbs have also been used as plaque removers (chew sticks), antimicrobials, analgesics, anti-inflammatory agents, and antiseptics. …”
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Morphine Epigenomically Regulates Behavior through Alterations in Histone H3 Lysine 9 Dimethylation in the Nucleus Accumbens by Sun, Hao Sheng, Maze, Ian, Dietz, David M., Scobie, Kimberly N., Kennedy, Pamela J., Damez-Werno, Diane, Neve, Rachael L., Zachario, Venetia, Shen, Li, Nestler, Eric J.

“…Through viral-mediated gene transfer and conditional mutagenesis, we found that overexpression of G9a in NAc opposes morphine reward and locomotor sensitization and concomitantly promotes analgesic tolerance and naloxone-precipitated withdrawal, whereas downregulation of G9a in NAc enhances locomotor sensitization and delays the development of analgesic tolerance. …”
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Functional Network Architecture Predicts Psychologically Mediated Analgesia Related to Treatment in Chronic Knee Pain Patients by Hashmi, Javeria Ali, Kong, Jian, Spaeth, Rosa, Khan, Sheraz, Kaptchuk, Ted J., Gollub, Randy Lyanne

“…Here, we theorized that topological network alignments in resting state scans predict psychologically conditioned analgesic responses to acupuncture treatment in chronic knee osteoarthritis pain patients (n = 45). …”
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Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association by Kong, Jian, Spaeth, Rosa, Cook, Amanda, Kirsch, Irving, Claggett, Brian, Smoller, Jordan W., Kaptchuk, Ted J., Vangel, Mark G., Gollub, Randy Lyanne

“…At least 14 days after completing experiment one, all subjects were invited to participate in experiment two, during which their analgesic responses to conditioned visual cues were tested. …”
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Low-power swept-source Raman spectroscopy by Atabaki, Amir H, Herrington, William F, Burgner, Christopher, Jayaraman, Vijaysekhar, Ram, Rajeev J

“…We characterize the dynamic range and spectral characteristics of this Raman spectrometer in detail, and use it for fingerprinting of different molecular species consumed everyday including analgesic tablets, nutrients in vegetables, and contaminated alcohol. …”
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The role of branding and pricing on health outcomes via the placebo response by Waber, Rebecca L

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Towards a more ethical animal model in biomedical research by Najjar, Deborah Anne

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The biosynthetic origin of psychoactive kavalactones in kava by Pluskal, Tomáš, Torrens-Spence, Michael P., Fallon, Timothy R., De Abreu, Andrea, Shi, Cindy H., Weng, Jing-Ke

“…Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct from those of conventional psychiatric drugs. …”
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The Role of Glutamatergic and Dopaminergic Neurons in the Periaqueductal Gray/Dorsal Raphe: Separating Analgesia and Anxiety by Taylor, Norman E., Pei, JunZhu, Zhang, Jie, Vlasov, Ksenia, Davis, Trevor, Taylor, Emma, Weng, Feng-Ju, Van Dort, Christa J., Solt, Ken, Brown, Emery Neal

“…The periaqueductal gray (PAG) is a significant modulator of both analgesic and fear behaviors in both humans and rodents, but the underlying circuitry responsible for these two phenotypes is incompletely understood. …”
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Measuring Nociception Under Anesthesia by Subramanian, Sandya

“…In summary, I have: 1) constructed and validated quantitative multi-dimensional measures of intraoperative nociceptive state using HRV and EDA; and 2) compared these measures to the existing Analgesic Nociception Index (ANI) index for nociception monitoring using data collected during surgery. …”
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Motor Cortex Neurostimulation Technologies for Chronic Post-stroke Pain: Implications of Tissue Damage on Stimulation Currents by O’Brien, Anthony T., Amorim, Rivadavio, Rushmore, R. Jarrett, Eden, Uri, Afifi, Linda, Dipietro, Laura, Valero-Cabré, Antoni, Wagner, Tim Andrew

“…We postulate that the effects of altered tissue properties in stroke regions may impact stimulation induced analgesic effects and/or lead to highly variable outcomes during brain stimulation treatments in CPSP.…”
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Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury by Raczynski, Arkadiusz R. (Arkadiusz Roland)

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A Multidimensional Approach to Pain Assessment in Critically Ill Infants During a Painful Procedure by Ranger, Manon, Celeste Johnston, C., Rennick, Janet E., Limperopoulos, Catherine, Heldt, Thomas, du Plessis, Adre J.

“…Discussion: We demonstrated with a multidimensional pain assessment approach that significant cerebral, physiological, and behavioral activity was present in response to a noxious procedure in critically ill infants despite the administration of analgesic treatment. Considering that the sedating agent significantly dampened pain behaviors, assessment of cerebral hemodynamic in the context of pain seems to be an important addition.…”
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Combining Electrodermal Activity With the Peak-Pain Time to Quantify Three Temporal Regions of Pain Experience by Bhatkar, Viprali, Picard, Rosalind W., Staahl, Camilla

“…The method accurately discriminates, for both pain models, the reduction of pain with clinically effective analgesics.</jats:p></jats:sec>…”
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Redesign of a Dioxygenase in Morphine Biosynthesis by Runguphan, Weerawat, Glenn, Weslee S., O'Connor, Sarah Ellen

“…Opium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids, including the analgesics codeine and morphine, in the morphinan pathway. …”
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Electrospun drug-eluting sutures for local anesthesia by Weldon, Christopher B., Tsui, Jonathan H., Shankarappa, Sahadev A., Nguyen, Vy T., Ma, Minglin, Kohane, Daniel S., Anderson, Daniel Griffith

“…Such sutures may enhance perioperative analgesia and mitigate the need for standard postoperative opioid analgesics.…”
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AI-Enabled, Ultrasound-Guided Handheld Robotic Device for Femoral Vascular Access by Brattain, Laura J., Pierce, Theodore T., Gjesteby, Lars A., Johnson, Matthew R., DeLosa, Nancy D., Werblin, Joshua S., Gupta, Jay F., Ozturk, Arinc, Wang, Xiaohong, Li, Qian, Telfer, Brian A., Samir, Anthony E.

“…Obtaining central vascular access to a deep artery or vein is important for administration of emergency drugs and analgesics, and rapid replacement of blood volume, as well as invasive sensing and emerging life-saving interventions. …”
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Development of Transcriptomic Resources for Interrogating the Biosynthesis of Monoterpene Indole Alkaloids in Medicinal Plant Species by Gongora-Castillo, Elsa, Childs, Kevin L., Fedewa, Greg, Hamilton, John P., Liscombe, David K., Magallanes-Lundback, Maria, Mandadi, Kranthi K., Nims, Ezekiel, Runguphan, Weerawat, Vaillancourt, Brieanne, Varbanova-Herde, Marina, DellaPenna, Dean, McKnight, Thomas D., O'Connor, Sarah Ellen, Buell, C. Robin

“…One group of plant-derived compounds, the monoterpene indole alkaloids (MIAs), includes well-documented therapeutic agents used in the treatment of cancer (vinblastine, vincristine, camptothecin), hypertension (reserpine, ajmalicine), malaria (quinine), and as analgesics (7-hydroxymitragynine). Our understanding of the biochemical pathways that synthesize these commercially relevant compounds is incomplete due in part to a lack of molecular, genetic, and genomic resources for the identification of the genes involved in these specialized metabolic pathways. …”
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