The opioid crisis: need for systems science research by Jalali, Seyed Mohammad Javad, Botticelli, Michael, Hwang, Rachael C., Koh, Howard K., McHugh, R. Kathryn

“…The opioid epidemic in the United States has had a devastating impact on millions of people as well as on their families and communities. …”
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Multimodal General Anesthesia: Theory and Practice by Brown, Emery Neal, Pavone, Kara, Naranjo, Marusa

“…Moreover, overreliance on opioids has contributed to the opioid epidemic in the United States. Spurred by concern of opioid overuse, balanced general anesthesia strategies are now using more agents to create the anesthetic state. …”
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