Mechanisms of lymphoma clearance induced by high-dose alkylating agents by Lossos, Chen, Liu, Yunpeng, Kolb, Kellie E, Christie, Amanda L, van Scoyk, Alexandria, Prakadan, Sanjay M, Shigemori, Kay, Stevenson, Kristen E, Morrow, Sara, Plana, Olivia D, Fraser, Cameron, Jones, Kristen L, Liu, Huiyun, Pallasch, Christian P, Modiste, Rebecca, Nguyen, Quang-De, Craig, Jeffrey W, Morgan, Elizabeth A, Vega, Francisco, Aster, Jon C, Sarosiek, Kristopher A, Shalek, Alex K, Hemann, Michael T, Weinstock, David M

“…The extraordinary activity of high-dose cyclophosphamide against some high-grade lymphomas was described nearly 60 years ago. Here we address mechanisms that mediate cyclophosphamide activity in bona fide human double-hit lymphoma. …”
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Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma by Sabatini, David, Wolfson, Rachel Laura, Efeyan, Alejo

“…Follicular lymphoma is an incurable B cell malignancy characterized by the t(14;18) translocation and mutations affecting the epigenome. …”
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Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death by Freinkman, Elizaveta, Chan, Sze Ham, Lewis, Caroline, Sabatini, David M.

“…Through metabolic gene expression analysis, we pinpoint the loss of squalene monooxygenase expression as a cause of cholesterol auxotrophy, particularly in ALK+ anaplastic large cell lymphoma (ALCL) cell lines and primary tumours. Squalene monooxygenase catalyses the oxidation of squalene to 2,3-oxidosqualene in the cholesterol synthesis pathway and its loss results in accumulation of the upstream metabolite squalene, which is normally undetectable. …”
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Lymphocyte-mediated drug nanoparticle delivery to disseminated lymphoma tumors in vivo by Huang, Bonnie

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Oncogenic HSP90 facilitates metabolic alterations in aggressive B-cell lymphomas by Calvo-Vidal, M Nieves, Zamponi, Nahuel, Krumsiek, Jan, Stockslager, Max A, Revuelta, Maria V, Phillip, Jude M, Marullo, Rossella, Tikhonova, Ekaterina, Kotlov, Nikita, Patel, Jayeshkumar, Yang, Shao Ning, Yang, Lucy, Taldone, Tony, Thieblemont, Catherine, Leonard, John P, Martin, Peter, Inghirami, Giorgio, Chiosis, Gabriela, Manalis, Scott R, Cerchietti, Leandro

“…This study reveals that oncogenic HSP90 supports metabolism in B-cell lymphoma cells and patients with diffuse large B-cell lymphoma, providing a novel mechanism of activity for HSP90 inhibitors.…”
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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma by Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E., Young, Richard A.

“…Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. …”
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Elucidating Targetable Genetic Vulnerabilities in Relapsed/Refractory Diffuse Large B-cell Lymphoma by Li, Audrey

“…Diffuse large B-cell lymphoma (DLBCL), the most prevalent form of non-Hodgkin lymphoma is marked by significant heterogeneity in its morphology, genetic irregularities, and clinical behavior. …”
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In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression by Ho, Emily E., Dubrovsky, Esther, Gertler, Frank, Meacham, Corbin Elizabeth, Hemann, Michael

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing by Lander, Eric Steven

“…To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor samples from patients with DLBCL and matched normal tissue. …”
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Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model by Bric, Anka, Miething, Cornelius, Bialucha, Carl Uli, Scuoppo, Claudio, Zender, Lars, Krasnitz, Alexander, Xuan, Zhenyu, Zuber, Johannes, Wigler, Michael, Hicks, James, McCombie, Richard W., Hemann, Michael, Hannon, Gregory J., Powers, Scott, Lowe, Scott W.

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Male Syrian Hamsters Experimentally Infected with Helicobacter spp. of the H. bilis Cluster Develop MALT-Associated Gastrointestinal Lymphomas by Woods, Stephanie, Ek, Courtney, Shen, Zeli, Feng, Yan, Ge, Zhongming, Muthupalani, Sureshkumar, Whary, Mark T, Fox, James G

“…-infected hamsters developed small intestinal lymphoma, in contrast to one control. Of the three lymphomas in H. spp.…”
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Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma by Nie, Man, Du, Likun, Ren, Weicheng, Joung, Julia, Ye, Xiaofei, Shi, Xi, Ciftci, Sibel, Liu, Dongbing, Wu, Kui, Zhang, Feng, Pan-Hammarström, Qiang

“…<jats:title>Abstract</jats:title><jats:p>Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoid malignancy and a highly heterogeneous disease. …”
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Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies by Schweighofer, C. D., Abruzzo, L., Frenzel, Lukas P., Wendtner, C. M., Leskov, Ilya B., Pallasch, Christian, Drake, Adam, Iliopoulou, Bettina P., Souza, A., Shen, C.-H., Hemann, Michael, Chen, Jianzhu

“…As a proof of principle, we used this model to show that the anti-CD52 antibody alemtuzumab effectively eliminates lymphoma cells from the spleen, liver and peripheral blood, but not from the brain. …”
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Commentary on: Is Banning Texturized Implants to Prevent Breast Implant–Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study by Clemens, Mark W, Knittel, Christopher R

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MicroRNAs Modulate Hematopoietic Lineage Differentiation by Lodish, Harvey F., Chen, Chang-Zheng, Bartel, David P.

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7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses, Spring 2007 by Grotenbreg, Gijsbert, Paquet, Marie-Eve

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Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers by Tonomura, Noriko, Elvers, Ingegerd, Thomas, Rachael, Megquier, Kate, Turner-Maier, Jason, Howald, Cedric, Sarver, Aaron L., Swofford, Ross, Frantz, Aric M., Ito, Daisuke, Mauceli, Evan, Arendt, Maja, Noh, Hyun Ji, Koltookian, Michele, Biagi, Tara, Fryc, Sarah, Williams, Christina, Avery, Anne C., Kim, Jong-Hyuk, Barber, Lisa, Burgess, Kristine, Karlsson, Elinor K., Azuma, Chieko, Modiano, Jaime F., Breen, Matthew, Lindblad-Toh, Kerstin, Lander, Eric Steven

“…Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. …”
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In vivo pool-based shRNA screens to identify modulators of disease progression in hematopoietic malignancies by Meacham, Corbin Elizabeth

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Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells by Abraham, Wuhbet, Zheng, Yiran, Huang, Bonnie, Bustamante Lopez, Sandra C, Irvine, Darrell J, Luo, Samantha

“…In a murine model of disseminated lymphoma, we expanded autologous polyclonal T cells ex vivo under conditions that retained homing receptors mirroring lymphoma cells, and functionalized these T cells to carry SN-38–loaded nanocapsules on their surfaces. …”
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T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell by Serwold, T., Hochedlinger, K., Swindle, J., Hedgpeth, J., Weissman, I. L., Jaenisch, Rudolf

“…Surprisingly, ≈50% of mice with prerearranged TCR genes develop spontaneous T cell lymphomas, which originate in the thymus. The lymphomas arise from developing T cells, and contain activated Notch1, similar to most human and mouse T-cell acute lymphoblastic lymphomas. …”
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