DNA Damage and Its Links to Neurodegeneration by Madabhushi, Ram, Pan, Ling, Tsai, Li-Huei

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Phenotyping Neurodegeneration in Human iPSCs by Li, Jonathan, Fraenkel, Ernest

“…However, many patients with neurodegenerative diseases do not have a known genetic cause. iPSCs offer a way to generate patient-specific models and study pathways of dysfunction in an in vitro setting in order to understand the causes and subtypes of neurodegeneration. Furthermore, iPSC-based models can be used to search for candidate therapeutics using high-throughput screening. …”
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Regulation of biochemical pathways involved in neurodegeneration by Pooler, Amy Melissa

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A magnetic resonance approach to neurodegeneration by Chen, Yin-Ching Iris

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An epigenetic blockade of cognitive functions in the neurodegenerating brain by Rei, Damien, Guan, Ji-Song, Wang, Wen-Yuan, Seo, Jinsoo, Hennig, Krista M., Nieland, Thomas J., Fass, Daniel M., Kao, Patricia F., Kahn, Martin, Su, Susan C., Samiei, Alireza, Joseph, Nadine, Haggarty, Stephen J., Delalle, Ivana, Tsai, Li-Huei, Graff, Johannes

“…Here we show that cognitive capacities in the neurodegenerating brain are constrained by an epigenetic blockade of gene transcription that is potentially reversible. …”
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Molecular Profiling and Mechanisms of Cerebrovascular Function in Health and Neurodegeneration by Garcia, Francisco J.

“…Furthermore, the presence of a bloodbrain barrier (BBB) provides protection to vulnerable neurons but poses a challenge for drug delivery. In neurodegeneration, BBB breakdown and vascular impairments are hallmarks that precede the onset of disease-specific phenotypes. …”
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Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration by Kim, Dohoon, Tsai, Li-Huei

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Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution by Hemberg, Martin, De Jager, Philip L., Ransohoff, Richard M., Mathys, Hansruedi, Adaikkan, Chinnakkaruppan, Gao, Fan, Young, Jennie Zin-Ney, Manet, Elodie, Regev, Aviv, Tsai, Li-Huei

“…Here, using single-cell RNA sequencing, we determined the transcriptome of more than 1,600 individual microglia cells isolated from the hippocampus of a mouse model of severe neurodegeneration with AD-like phenotypes and of control mice at multiple time points during progression of neurodegeneration. …”
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Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? by Khurana, Vikram, Lindquist, Susan

“…Here, we describe why the budding yeast Saccharomyces cerevisiae has a unique role in the neurodegeneration armamentarium. As the best-understood and most readily analysed eukaryotic organism, S. cerevisiae is delivering mechanistic insights into cell-autonomous mechanisms of neurodegeneration at an interactome-wide scale.…”
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S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration by Bhat, Vadiraja B., Seneviratne, Uthpala Indrajith, Nott, Alexander, Kodihalli, Ravindra, Wishnok, John S, Tsai, Li-Huei, Tannenbaum, Steven R

“…SNOTRAP identified 313 endogenous SNO-sites in 251 proteins in the mouse brain, of which 135 SNO-proteins were detected only during neurodegeneration. S-nitrosation in the brain shows regional differences and becomes elevated during early stages of neurodegeneration in the CK-p25 mouse. …”
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S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration by Bhat, Vadiraja B., Seneviratnea, Uthpala, Nott, Alexi, Ravindra, Kodihalli C., Wishnok, John S, Tsai, Li-Huei, Tannenbaum, Steven R

“…SNOTRAP identified 313 endogenous SNO-sites in 251 proteins in the mouse brain, of which 135 SNO-proteins were detected only during neurodegeneration. S-nitrosation in the brain shows regional differences and becomes elevated during early stages of neurodegeneration in the CK-p25 mouse. …”
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Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma by Chen, Huihui, Cho, Kin-Sang, Vu, T. H. Khanh, Chen, Guochun, Mathew, Rose, McHam, M. Lisa, Fazelat, Ahad, Lashkari, Kameran, AU, Ngan Pan Bennett, TSE, Joyce Ka Yu, Li, Yingqian, Yu, Honghua, Yang, Lanbo, Stein-Streilein, Joan, Ma, Chi Him Eddie, Woolf, Clifford J., Jager, Martine J., Chen, Jianzhu, Chen, Dong F., Shen, Chase, Kaur, Mandeep, Fox, James G, Whary, Mark T.

“…Furthermore, retina-infiltrating T cells cross-react with human and bacterial HSPs; mice raised in the absence of commensal microflora do not develop glaucomatous T-cell responses or the associated neurodegeneration. These results provide compelling evidence that glaucomatous neurodegeneration is mediated in part by T cells that are pre-sensitized by exposure to commensal microflora.…”
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Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration by Morshed, Nader, Ralvenius, William, Nott, Alexander, Watson, Lauren Ashley, Rodriguez, Felicia H, Akay, Leyla Anne, Joughin, Brian Alan, Pao, Ping-Chieh, Penney, Jay, LaRocque, Lauren, Mastroeni, Diego, Tsai, Li‐Huei, White, Forest M.

“…Collectively, our results point to an important role for mouse Siglec-F and human Siglec-8 in regulating microglial activation during neurodegeneration.…”
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Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration by Victor, Matheus B, Tsai, Li-Huei

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A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration by Graeff, Johannes, Kahn, Martin, Samiei, Alireza, Gao, Jun, Ota, Kristie, Rei, Damien, Tsai, Li-Huei

“…We found that in this model, CR significantly delayed the onset of neurodegeneration and synaptic loss and dysfunction, and thereby preserved cognitive capacities. …”
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Using network inference to discover molecular pathways underlying cytokine synergism and age-related neurodegeneration by Hwang, Bryce

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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy by Wu, Tiffany, Dejanovic, Borislav, Gandham, Vineela D, Gogineni, Alvin, Edmonds, Rose, Schauer, Stephen, Srinivasan, Karpagam, Huntley, Melanie A, Wang, Yuanyuan, Wang, Tzu-Ming, Hedehus, Maj, Barck, Kai H, Stark, Maya, Ngu, Hai, Foreman, Oded, Meilandt, William J, Elstrott, Justin, Chang, Michael C, Hansen, David V, Carano, Richard AD, Sheng, Morgan, Hanson, Jesse E

“…These results demonstrate that complement activation contributes to neurodegeneration caused by tau pathology and suggest that blocking C3 function might be protective in AD and other tauopathies.…”
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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy by Wu, Tiffany, Dejanovic, Borislav, Gandham, Vineela D., Gogineni, Alvin, Edmonds, Rose, Schauer, Stephen, Srinivasan, Karpagam, Huntley, Melanie A., Wang, Yuanyuan, Wang, Tzu-Ming, Hedehus, Maj, Barck, Kai H., Stark, Maya, Ngu, Hai, Foreman, Oded, Meilandt, William J., Elstrott, Justin, Chang, Michael C., Hansen, David V., Carano, Richard A.D., Sheng, Morgan, Hanson, Jesse E.

“…These results demonstrate that complement activation contributes to neurodegeneration caused by tau pathology and suggest that blocking C3 function might be protective in AD and other tauopathies.…”
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The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration by Zhou, Jiechao, Wade, Sarah D, Graykowski, David, Xiao, Mei-Fang, Zhao, Binhui, Giannini, Lucia AA, Hanson, Jesse E, van Swieten, John C, Sheng, Morgan, Worley, Paul F, Dejanovic, Borislav

“…Together, these results show that Nptx2 regulates complement activity and microglial synapse elimination in the brain and that diminished Nptx2 concentrations might exacerbate complement-mediated neurodegeneration in patients with FTD.</jats:p>…”
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Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration by Welch, Gwyneth M, Boix, Carles A, Schmauch, Eloi, Davila-Velderrain, Jose, Victor, Matheus B, Dileep, Vishnu, Bozzelli, P Lorenzo, Su, Qiao, Cheng, Jemmie D, Lee, Audrey, Leary, Noelle S, Pfenning, Andreas R, Kellis, Manolis, Tsai, Li-Huei

“…<jats:p>DNA double-strand breaks (DSBs) are linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence neuroinflammation associated with neurodegeneration. …”
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