Integrated genomic analyses of ovarian carcinoma by Meyerson, Matthew L., Lander, Eric Steven

“…A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. …”
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Inhabiting the world : architecture, urbanism, and the global moral-politics of Marion Mahony and Walter Burley Griffin by Banerji, Shiben

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Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer by Emmons, Tiffany R, Giridharan, Thejaswini, Singel, Kelly L, Khan, ANM Nazmul H, Ricciuti, Jason, Howard, Kaitlyn, Silva-Del Toro, Stephanie L, Debreceni, Ivy L, Aarts, Cathelijn EM, Brouwer, Mieke C, Suzuki, Sora, Kuijpers, Taco W, Jongerius, Ilse, Allen, Lee-Ann H, Ferreira, Viviana P, Schubart, Anna, Sellner, Holger, Eder, Jörg, Holland, Steven M, Ram, Sanjay, Lederer, James A, Eng, Kevin H, Moysich, Kirsten B, Odunsi, Kunle, Yaffe, Michael B, Zsiros, Emese, Segal, Brahm H

“…In this study, we used ascites fluid supernatants (ASC) from patients with ovarian cancer as an authentic component of the TME to evaluate the effects of ASC on neutrophil function and mechanisms for neutrophil-driven immune suppression. …”
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Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer by Emmons, Tiffany R., Giridharan, Thejaswini, Singel, Kelly L., Khan, ANM Nazmul H., Ricciuti, Jason, Howard, Kaitlyn, Silva-Del Toro, Stephanie L., Debreceni, Ivy L., Aarts, Cathelijn E.M., Brouwer, Mieke C., Suzuki, Sora, Kuijpers, Taco W., Jongerius, Ilse, Allen, Lee-Ann H., Ferreira, Viviana P., Schubart, Anna, Sellner, Holger, Eder, Jörg, Holland, Steven M., Ram, Sanjay, Lederer, James A., Eng, Kevin H., Moysich, Kirsten B., Odunsi, Kunle, Yaffe, Michael B., Zsiros, Emese, Segal, Brahm H.

“…In this study, we used ascites fluid supernatants (ASC) from patients with ovarian cancer as an authentic component of the TME to evaluate the effects of ASC on neutrophil function and mechanisms for neutrophil-driven immune suppression. …”
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer by Kong, Stephanie Mabel

“…Ovarian cancer remains the most lethal gynecologic malignancy in the United States. …”
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An intraperitoneal implantable drug delivery device for the treatment of ovarian cancer by Ye, Hongye

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Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells by Xu, Ying-Qi, Chen, Wen-Rong, Tsosie, Jonathan, Xie, Xi, Li, Peng, Wan, Jian-Bo, He, Cheng-Wei, Chen, Mei-He

“…These results demonstrate that the curcumin-niosome system is a promising strategy for the delivery of curcumin and ovarian cancer therapy.…”
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Design of an intraperitoneal drug-release device for advanced ovarian cancer therapy by Tanenbaum, Laura Melanie

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Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

“…To provide a detailed analysis of the molecular components and underlying mechanisms associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based proteomic characterization of 174 ovarian tumors previously analyzed by The Cancer Genome Atlas (TCGA), of which 169 were high-grade serous carcinomas (HGSCs). …”
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Engineering layer-by-layer nanoparticles for the targeted delivery of therapeutics to ovarian cancer by Correa, Santiago (Santiago Correa Echavarria)

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CRISPRi screens to identify combination therapies for the improved treatment of ovarian cancer by Handly, Erika Daphne.

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A single-cell landscape of high-grade serous ovarian cancer

“…Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis1. …”
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A single-cell landscape of high-grade serous ovarian cancer by Izar, Benjamin, Tirosh, Itay, Stover, Elizabeth H., Wakiro, Isaac, Cuoco, Michael S., Alter, Idan, Rodman, Christopher, Leeson, Rachel, Su, Mei-Ju, Shah, Parin, Iwanicki, Marcin, Walker, Sarah R., Kanodia, Abhay, Melms, Johannes C., Mei, Shaolin, Lin, Jia-Ren, Porter, Caroline B. M., Slyper, Michal, Waldman, Julia, Jerby-Arnon, Livnat, Ashenberg, Orr, Brinker, Titus J., Mills, Caitlin, Rogava, Meri, Vigneau, Sébastien, Sorger, Peter K., Garraway, Levi A., Konstantinopoulos, Panagiotis A., Liu, Joyce F., Matulonis, Ursula, Johnson, Bruce E., Rozenblatt-Rosen, Orit, Rotem, Asaf, Regev, Aviv

“…Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis1. …”
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Chemotherapy-Eluting Intraperitoneal Implants for Advanced Stage Ovarian Cancer Treatment by Subramanyam, Kriti S.

“…IP chemotherapy has improved survival in ovarian cancer (OC) patients, but its adoption has suffered due to resource requirements and dose-limiting toxicities. …”
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VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients by Khan, ANM N. H., Emmons, Tiffany R., Magner, William J., Alqassim, Emad, Singel, Kelly L., Ricciuti, Jason, Eng, Kevin H., Odunsi, Kunle, Tomasi, Thomas B., Lee, Kelvin, Abrams, Scott I., Mesa, Circe, Segal, Brahm H.

“…Abstract The ovarian tumor microenvironment (TME) is characterized by the accumulation of immunosuppressive tumor-associated macrophages (TAMs) and granulocytic cells. …”
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Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors by Chowanadisai, Winyoo, Messerli, Shanta M., Miller, Daniel Handel, Medina, Jamie E., Hamilton, Joshua W., Messerli, Mark A., Brodsky, Alexander S.

“…The majority of ovarian tumors eventually recur in a drug resistant form. …”
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Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

“…© 2020 The Authors Hu et al. provide an integrated proteomic and glycoproteomic characterization of high-grade serous ovarian carcinomas and relevant non-tumor tissues, which reveals tumor-specific glycosylation, uncovers different glycosylation associated with three tumor clusters, and identifies glycosylation enzymes correlated with glycosylation alterations.…”
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Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

“…© 2020 The Authors Hu et al. provide an integrated proteomic and glycoproteomic characterization of high-grade serous ovarian carcinomas and relevant non-tumor tissues, which reveals tumor-specific glycosylation, uncovers different glycosylation associated with three tumor clusters, and identifies glycosylation enzymes correlated with glycosylation alterations.…”
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UNRAVELING THE ORIGIN OF OVERIONIZED PLASMA IN THE GALACTIC SUPERNOVA REMNANT W49B by Lopez, Laura A., Pearson, Sarah, Ramirez-Ruiz, Enrico, Castro, Daniel, Yamaguchi, Hiroya, Slane, Patrick O., Smith, Randall K.

“…Using these results, we find that W49B is overionized in the west, with a gradient of overionization increasing from east to west. …”
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Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry by Correa, Santiago, Boehnke, Natalie, Barberio, Antonio E, Deiss-Yehiely, Elad, Shi, Aria, Oberlton, Benjamin, Smith, Sean G, Zervantonakis, Ioannis, Dreaden, Erik C, Hammond, Paula T

“…Here, we used electrostatic layer-by-layer (LbL) assembly to screen 10 different surface chemistries for their ability to preferentially target human ovarian cancer in vitro. Our screen identified that poly-l-aspartate, poly-l-glutamate, and hyaluronate-coated LbL nanoparticles have striking specificity for ovarian cancer, while sulfated poly(β-cyclodextrin) nanoparticles target noncancerous stromal cells. …”
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