Gene regulatory activity of newly discovered small RNA species in Drosophila melanogaster by Leong, Onn Kit

“…Unexpectedly, we found that the Glut4EF hairpin can directly regulate host gene expression via a Drosha-dependent, RISC-independent manner. …”
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Elucidating the role of prolidase in impairment of insulin signaling via abnormalities in integrinβ1 signaling pathway. by Ng, Genevieve Gek Fong.

“…We investigated the 1) differences in PEPD mRNA and protein expression in insulin-sensitive versus insulin-resistant muscle samples; and if 2) associated prolidase, integrinβ1, PKB and GLUT4 expression levels are altered. Western blots demonstrated increased PEPD expression in insulin-resistant subjects with no visble change in associated integrinβ1 receptor expression. …”
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Mechanism of adipocyte hormone secretion (leptin and resistin) by Goh, Kian Hong.

“…These vesicles did not co-localize with rab5 (marker of early endosomes) or Glut-4 (glucose transporter-4) containing vesicles. …”
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Plant‑derived cell‑penetrating microprotein α‑astratide aM1 targets Akt signaling and alleviates insulin resistance by Dutta, Bamaprasad, Loo, Shining, Kam, Antony, Tam, James P.

“…Here we show that aM1 is a cell-penetrating insulin mimetic, enters cells by endocytosis, and activates the PI3K/Akt signaling pathway independent of the insulin receptor leading to translocation of glucose transporter GLUT4 to the cell surface to promote glucose uptake. …”
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Understanding extracellular vesicles biology through the study of protein dynamics using pSILAC-based quantitative proteomics by Tan, Chee Fan

“…Gene analysis of the tibialis anterior muscle from mice injected with basal mHypoA 2/28 EVS showed an increase in GLUT4 expression that is independent of leptin action. …”
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