Development of TCM herb and immunosuppressant drug interaction database by Quek, Leona Yan Peng

“…One such risk includes the potential herb-drug interactions when TCM herbs are being consumed with conventional drugs that have a narrow therapeutic range such as immunosuppressants. This could often result in toxic effects or reduced therapeutic efficiency. …”
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Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis by Zhou, Jingying, Wang, Huanyu, Shu, Ting, Wang, Jing, Yang, Weiqin, Li, Jingqing, Ding, Lipeng, Liu, Man, Sun, Hanyong, Wong, John, Lai, Paul Bo-San, Tsang, Shun-Wa, Ward, Simon E., Chow, King-Lau, Sung, Joseph Jao Yiu, Cheng, Alfred Sze-Lok

“…Taken together, our findings unravel mechanistic insights into MDSC-mediated immunosuppression and offer a therapeutic kinase-target for cancer immunotherapy.…”
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Art of tumor immunity: extricating hypoxia-driven immunosuppression in the solid tumor microenvironment by Tay, Apple Hui Min

“…The fate of tumors, from initiation to in situ carcinoma and ultimately metastasis, is intricately tied to the balance between the immune system’s effector cytotoxic and tolerogenic immunosuppressive responses, collectively known as tumor immunity. …”
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An adjuvant micelle-based multifunctional nanosystem for tumor immunotherapy by remodeling three types of immunosuppressive cells by Meng, Siyu, Du, Huiping, Li, Xiang, Zheng, Xinmin, Zhao, Pan, Yuan, Zhang, Huang, Shaohui, Zhao, Yanli, Dai, Liangliang

“…Immunotherapy is restricted by a complex tumor immunosuppressive microenvironment (TIM) and low drug delivery efficiency. …”
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The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38) by Kang, Cong Bao, Tai, Jeff, Chia, Joel, Yoon, Ho Sup

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PPP1R15A-expressing monocytic MDSCs promote immunosuppressive liver microenvironment in fibrosis-associated hepatocellular carcinoma by Liu, Xiaoyu, Liu, Man, Wu, Haoran, Tang, Wenshu, Yang, Weiqin, Chan, Thomas T. H., Zhang, Lingyun, Chen, Shufen, Xiong, Zhewen, Liang, Jianxin, Si-Tou, Willis Wai-Yiu, Shu, Ting, Li, Jingqing, Cao, Jianquan, Zhong, Chengpeng, Sun, Hanyong, Kwong, Tsz Tung, Leung, Howard H. W., Wong, John, Lai, Paul Bo-San, To, Ka-Fai, Xiang, Tingxiu, Sung, Joseph Jao Yiu, Chan, Stephen Lam, Zhou, Jingying, Cheng, Alfred Sze-Lok

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Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver by Gan, Wei Liang, Ren, Xi, Ng, Vanessa Hui En, Ng, Larry, Song, Yangyang, Tano, Vincent, Han, Jian, An, Omer, Xie, Jinghe, Ng, Bryan Y. L., Tay, Daryl Jin Tai, Tang, Sze Jing, Shen, Haoqing, Khare, Shruti, Chong, Kelvin Han Chung, Young, Dan Yock, Wu, Bin, DasGupta, Ramanuj, Chen, Leilei

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Final report of molecular characterization and regulatory mechanism of immunosuppressant FK506 binding protein 38 (FKBP38) in apoptosis - SEP (Supplementary equipment project RG129/05) by Yoon, Ho Sup.

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Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study by Tang, Raymond S. Y., Sattayalertyanyong, Onuma, Kuo, Yu-Ting, Park, Kenneth H., Anastassiades, Constantinos, Ligresti, Dario, Hayashi, Nobuhiko, Hasan, Aws, Kim, Tae-Hyeon, Pausawasdi, Nonthalee, Wang, Hsiu-Po, Lo, Simon K., Ho, Khek-Yu, Barresi, Luca, Traina, Mario, Yasuda, Ichiro, Savides, Thomas J., Koo, Chieh-Sian, Chan, Ting Ting, Lam, Thomas Y. T., Sung, Joseph Jao Yiu

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Study of hypoxia driven pancreatic cancer development by Gupta, Nikhil

“…The hypoxic environment in tumor resists the infiltration of T-cells as compared to the normoxic area of the same tumor, suggesting its role in immunosuppression. Furthermore, hypoxia-induced exosomes also promote cancer development by enhancing migration, angiogenesis, and early metastasis in solid tumors. …”
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Targeted immunotherapy for hair regrowth and regeneration by Toh, En Qi, Wang, Etienne C. E.

“…While the main strategy for treating inflammatory conditions is local or systemic immunosuppression, immunotherapy aims to stimulate parts or all of the immune system to bring about a therapeutic response. …”
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Molecular characterisation of the effects of classical chemotherapy on Candida albicans and systemic candidiasis by Teoh, Flora Poh Leng

“…Due to chemotherapy-induced immunosuppression and epithelial barrier disruption, cancer patients are well-known to be at increased risk of opportunistic infection, such as those caused by the dimorphic fungus Candida albicans. …”
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Adaptor regulation of LFA-1 signaling in T lymphocyte migration : potential druggable targets for immunotherapies? by Verma, Navin K., Kelleher, Dermot

“…Specific blockade of these interactions has validated LFA-1 as a therapeutic target in many chronic inflammatory diseases, however LFA-1 antagonists have not been clinically successful due to the development of a general immunosuppression, causing fatal side effects. Growing evidence has now established that LFA-1 mediates an array of intracellular signaling pathways by triggering a number of downstream molecules. …”
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Development of core-shell scaffold with GelMA for cell encapsulation by Zhu, Jayden Houyu

“…However, the shortage of donors and lifelong immunosuppression side effect drives the need for new regeneration treatment. …”
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Targeting adenosine-2 B receptor : a potential metabolic immune checkpoint by Tay, Hui Min

“…Adenosine is an anti-inflammatory and immunosuppressive metabolite that binds to the adenosine receptors (AR) - A1R, A2AR, A2BR and A3R. …”
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In-vitro characterization of microencapsulated microtissue viability by Chua, Yu Qing

“…Although islet transplantation is an alternative treatment of T1DM without the excessive need of exogenous insulin therapy which is the typical method of treatment, it still has its restrictions such as the lack of donors due to the need of adequate dose of islets, long term immunosuppressive therapy and insulin resistance. The transplantation of immuno-isolated islets is a potential approach to treat T1DM as it enables the transplanted islets to produce insulin to restore normoglycemia without the need of immunosuppression. …”
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Isolated gallbladder tuberculosis mimicking acute cholecystitis : a case report by Chan, Kai Siang, Shelat, Vishal G., Tan, Cher Heng, Tang, Yee Lin, Junnarkar, Sameer P.

“…Gallbladder tuberculosis is a rare entity but should be suspected in patients from endemic regions with risk factors such as underlying immunosuppression or history of tuberculosis. Case Summary: We present a case of gallbladder tuberculosis presenting as acute cholecystitis. …”
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Isolated anterior mediastinal tuberculosis in an immunocompetent patient by Maguire, S., Chotirmall, Sanjay Haresh, Parihar, V., Cormican, L., Ryan, C., O’Keane, C, Redmond, K., Smyth, C.

“…Cases similar to this have been documented in immunosuppressed patients however in our case no evidence of immunosuppression was found. …”
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Recent progresses in phototherapy-synergized cancer immunotherapy by Li, Jingchao, Pu, Kanyi, Ng, Chee Wee

“…Future advancements targeting different cancer checkpoints that could offer better immunosuppression coupled with other phototherapeutic strategies remains to be explored in accomplishing complete elimination of cancer.…”
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Current status of stem cell-derived therapies for Parkinson’s disease : from cell assessment and imaging modalities to clinical trials by Jang, Se Eun, Qiu, Lifeng, Chan, Ling Ling, Tan, Eng-King, Zeng, Li

“…Modifying factors include (1) source of the stem cells, (2) quality of the stem cells, (3) age of the patient, (4) stage of disease progression at the time of cell therapy, (5) surgical technique/practices, and (6) the use of immunosuppression. We await the outcomes of joint efforts in clinical trials around the world such as NYSTEM and CiRA to further guide us in the selection of the most suitable parameters for cell-based neurotransplantation in PD.…”
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