Bioinformatics investigations on multi-omics datasets of neurodegeneration by Lim, Jolyn Jia Jia

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Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration by Tan, Chin Hong, Bonham, Luke W., Fan, Chun Chieh, Mormino, Elizabeth C., Sugrue, Leo P., Broce, Iris J., Hess, Christopher P., Yokoyama, Jennifer S., Rabinovici, Gil D., Miller, Bruce L., Yaffe, Kristine., Schellenberg, Gerard D., Kauppi, Karolina, Holland, Dominic, McEvoy, Linda K., Kukull, Walter A., Tosun, Duygu, Weiner, Michael W., Sperling, Reisa A., Bennett, David A., Hyman, Bradley T., Andreassen, Ole A., Dale, Anders M., Desikan, Rahul S.

“…Beyond APOE, we show that in living subjects, polygenic hazard scores were associated with amyloid deposition and neurodegeneration in susceptible brain regions. Polygenic hazard scores may also be useful for the identification of individuals at the highest risk for developing multi-aetiological dementia.…”
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Neurofilament light as a blood biomarker for neurodegeneration in down syndrome by Strydom, Andre, Heslegrave, Amanda, Startin, Carla M., Mok, Kin Y., Hardy, John, Groet, Jurgen, Nizetic, Dean, Zetterberg, Henrik

“…Conclusions NF-L is a biomarker for neurodegeneration in DS with potential for use in future clinical trials to prevent or delay dementia.…”
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MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration by Ren, Mengda, Yang, Ying, Heng, Kelsey Hwee Yee, Ng, Lu Yi, Chong, Claris Yuin-Yi, Ng, Yan Ting, Gorur-Shandilya, Srinivas, Lee, Rachel Min Qi, Lim, Kah Leong, Zhang, Jing, Koh, Tong-Wey

“…The resulting neurodegeneration can be suppressed by overexpressing a glycolytic enzyme or treatment with deferoxamine, suggesting that compensatory glycolysis is neuroprotective. …”
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Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia by Vipin, Ashwati, Koh, Chen Ling, Wong, Benjamin Yi Xin, Zailan, Fatin Zahra, Tan, Jayne Yi, Soo, See Ann, Satish, Vaynii, Kumar, Dilip, Wang, Brian Zhiyang, Ng, Adeline Su Lyn, Chiew, Hui Jin, Ng, Kok Pin, Kandiah, Nagaendran

“…We examined amyloid-tau-neurodegeneration biomarker effects on cognition in a Southeast-Asian cohort of 84 sporadic young-onset dementia (YOD; age-at-onset <65 years) patients. …”
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Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling by Adav, Sunil Shankar, Sze, Siu Kwan

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Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition by Tan, Chin Hong, Tan, Jacinth J. X.

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Modulation of sphingolipids, cholesterol and saturated fatty acids interact with the neurodegeneration in the Drosophila blue cheese mutant. by Boo, George.

“…To elucidate the association between aberrant metabolism of lipids and age-related neurodegeneration, we study the Drosophila neurodegenerative blue cheese (bchs) mutant. bchs is associated with lysosomal trafficking and autophagosomal degradation of aggregated proteins. …”
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The role of tyrosine hydroxylase-dopamine pathway in Parkinson's disease pathogenesis by Zhou, Zhi Dong, Saw, Wuan Ting, Ho, Patrick Ghim Hoe, Zhang, Zhi Wei, Zeng, Li, Chang, Ya Yin, Sun, Alfred Xu Yang, Ma, Dong Rui, Wang, Hong Yan, Zhou, Lei, Lim, Kah-Leong, Tan, Eng-King

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Brief report : isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration by Murray, Aoife, Letourneau, Audrey, Canzonetta, Claudia, Stathaki, Elisavet, Gimelli, Stefania, Sloan-Bena, Frederique, Abrehart, Robert, Goh, Pollyanna, Lim, Shuhui, Baldo, Chiara, Dagna-Bricarelli, Franca, Hannan, Saad, Mortensen, Martin, Ballard, David, Syndercombe Court, Denise, Fusaki, Noemi, Hasegawa, Mamoru, Smart, Trevor G., Bishop, Cleo, Antonarakis, Stylianos E., Groet, Jürgen, Nizetic, Dean

“…DS is also a unique genetic system for investigation of pathological and protective mechanisms for accelerated ageing, neurodegeneration, dementia, cancer, and other important common diseases. …”
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Mitochondrial regulation of microglial immunometabolism in Alzheimer’s disease by Fairley, Lauren H., Wong, Jia Hui, Barron, Anna M.

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High diagnostic utility incorporating a targeted neurodegeneration gene panel with MRI brain diagnostic algorithms in patients with young-onset cognitive impairment with leukodystrophy by Chen, Zhiyong, Tan, Yi Jayne, Lian, Michelle Mulan, Tandiono, Moses, Foo, Jia Nee, Lim, Weng Khong, Kandiah, Nagaendran, Tan, Eng-King, Ng, Adeline S. L.

“…We performed sequencing using a custom-designed panel of 200 neurodegeneration-associated genes on 45 patients with young-onset cognitive impairment with leukodystrophy, and classified them based on van der Knaap et al.'…”
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Liver's influence on the brain through the action of bile acids by Yeo, Xin Yi, Tan, Li Yang, Chae, Woo Ri, Lee, Dong-Yup, Lee, Yong-An, Wuestefeld, Torsten, Jung, Sangyong

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Longitudinal analysis of retinal microvascular and choroidal imaging parameters in Parkinson's disease compared with controls by Kundu, Anita, Ma, Justin P., Robbins, Cason B., Pant, Praruj, Gunasan, Vithiya, Agrawal, Rupesh, Stinnett, Sandra, Scott, Burton L., Moore, Kathryn P. L., Fekrat, Sharon, Grewal, Dilraj S.

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Uncovering Neurodegenerative Protein Modifications via Proteomic Profiling by Gallart-Palau, Xavier, Serra, Aida, Sze, Siu Kwan

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Effects on diet-induced autophagy in metazoa by Fun, Xiu Hui

“…This study aims to determine the effects of high fat and sugar diets on neurodegeneration and lipid composition in a genetic mutant model affecting autophagy in Drosophila. …”
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Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases by Lo, Chih Hung, Zeng, Jialiu

“…Similar lysosomal abnormalities are also present in sporadic forms of neurodegeneration, although the underlying pathogenic mechanisms are unclear and remain to be investigated. …”
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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly by Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B., Hoshi, Minako

“…Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. …”
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Effects of angular guidance in shaping neuronal polarity and neurites growth direction by Chong, Swee Tong

“…Neurodegeneration can result from the loss of neuronal polarity, the loss of neurite directionality or even the breakdown of neuronal networks. …”
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Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition by Kan, Cheuk Ni, Xu, Xin, Schmetterer, Leopold, Venketasubramanian, Narayanaswamy, Chen, Christopher, Tan, Chin Hong

“…Lower composite MRI scores corresponding to greater comorbid neurodegeneration and CeVD burden were associated with hyperactivity (OR = 1.48) and apathy (OR = 1.90) subsyndromes. …”
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