Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia by Pennell, D.J., Porter, J.B., Cappellini, M.D., El-Beshlawy, A., Chan, L.L., Aydinok, Y., Elalfy, M.S., Sutcharitchan, P., Li, C.K., Ibrahim, H., Viprakasit, V., Kattamis, A., Smith, G., Habr, D., Domokos, G., Roubert, B., Taher, A.

“…Cardiac iron overload causes most deaths in beta-thalassemia major. …”

The safety, tolerability, and efficacy of a liquid formulation of deferiprone in young children with transfusional iron overload by El Alfy, M., Sari, T.T., Lee, C.L., Tricta, F., El-Beshlawy, A.

“…The results of this study show a favorable benefit/risk ratio of deferiprone oral solution for the treatment of young children with transfusional iron overload.…”

Quality of life in transfusion-dependent thalassaemia patients on desferrioxamine treatment by Dahlui, M., Hishamshah, M.I., Rahman, A.J.A., Aljunid, S.M.

“…Optimum desferrioxamine usage reduces iron overload complications and provides a better quality of life.…”

Chelation therapy with desferrioxamine does not normalize ferritin level but attenuates oxidative damage and improves total antioxidant level in Malaysian Chinese beta-thalassaemia... by Kuppusamy, U.R., Tan, J.

“…Regular blood transfusions cause iron-overload that leads to oxidative damage which can hasten mortality. …”
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Prevalence of growth and endocrine disorders in Malaysian children with transfusion-dependent thalassaemia by Tan, Khian Aun, Lum, Su Han, Yahya, Abqariyah, Krishnan, Shekhar, Jalaludin, Muhammad Yazid, Lee, Way Seah

“…INTRODUCTION Endocrine dysfunction due to iron overload secondary to frequent blood transfusions is a common complication in children with transfusion-dependent thalassaemia (TDT). …”

Prevention of hepatocellular carcinoma in the Asia-Pacific region: Consensus statements by Farrell, G.C., Chan, H.L.Y., Yuen, M.F., Amarapurkar, D.N., Chutaputti, A., Fan, J.G., Hou, J.L., Han, K.H., Kao, J.H., Lim, S.G., Mohamed, R., Sollano, J., Ueno, Y., Prevent, Asai-Pacific Working Party

“…With hemochromatosis, family screening, early diagnosis and correcting iron overload to prevent liver fibrosis prevents HCC. …”

Body iron status and gastric cancer risk in the EURGAST study by Fonseca-Nunes, A., Agudo, A., Aranda, N., Arija, V., Cross, A.J., Molina, E., Jose Sanchez, M., Bueno-de-Mesquita, H.B, Siersema, P., Weiderpass, E., Krogh, V., Mattiello, A., Tumino, R., Saieva, C., Naccarati, A., Ohlsson, B., Sjoberg, K., Boutron-Ruault, M.C., Cadeau, C., Fagherazzi, G., Boeing, H., Steffen, A., Kuehn, T., Katzke, V., Tjonneland, A., Olsen, A., Khaw, K.T, Wareham, N., Key, T., Lu, Y., Riboli, E., Peeters, P.H., Gavrila, D., Dorronsoro, M., Ramon Quiros, J., Barricarte, A., Jenab, M., Zamora-Ros, R., Freisling, H., Trichopoulou, A., Lagiou, P., Bamia, C., Jakszyn, P.

“…Iron is highly reactive, iron levels in the body rise with inflammation, and the iron-overload disorder hemochromatosis is associated with an increased risk of gastric cancer. …”