Cytotoxicity effect of 6-mercaptopurine and 6-mercaptopurine riboside on RAW 264.7 and HIG-82 cell lines by Che Ku Daud, Che Ku Dahlan, Zailani, Muhamad Zulhilmi, Sukiman, Nor Erma Suryana, Tham, Chau Ling, Ahmad, Zuraini, Yong, Yoke Keong, Mohd Zain, Zetty Nadia, Abdullah, Muhammad Nazrul Hakim

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Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system by Dorniani, Dena, Hussein, Mohd. Zobir, Kura, Aminu Umar, Fakurazi, Sharida, Shaari, Abdul Halim, Ahmad, Zalinah

“…The release of 6-mercaptopurine from the FCMP nanocomposite was found to be sustained and governed by pseudo-second order kinetics. …”
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Anti-arthritic effects of 6-mercaptopurine and its derivatives in arthritis-induced model, In vitro and In vivo by Che Ku Daud, Che Ku Dahlan

“…In this study, four thiopurine compounds namely, 6- mercaptopurine (6-MP), 6-MP riboside, 6-thioguanine (6-TG) and 6-thioxanthine (6- TX) with diclofenac (a non-steroidal anti-inflammatory drug; NSAID) as positive control were screened for their cytotoxicity and anti-inflammatory properties by evaluating the cell cytotoxicity and the nitric oxide (NO) inhibitory activities upon activated fibroblast synoviocytes (HIG-82) and macrophage (RAW 264.7) cell lines with phorbol-12- myristate acetate (PMA) and lipopolysaccharide (LPS), respectively. …”
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The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach by Bannur, Zakaria, Teh, Lay Kek, Hennesy, T., Wan Rosli, Wan Rosalina, Mohamad, Norsarwany, Nasir, Ariffin, Ankathil, Ravindran, Zakaria, Zainul Amiruddin, Baba, Aziz, Salleh, Mohd Zaki

“…Methods Metabolomic profile of 21 ALL patients treated with 6-mercaptopurine and 10 healthy volunteers were analysed using liquid chromatography/mass spectrometry quadrupole-time of flight (LC/MS Q-TOF). …”

Cytotoxic profiles of a nanodrug delivery based on 6-mercaptopurine-coated magnetite-peg nanoparticles towards leukemia (WEHI-3B) cell lines by Dorniani, Dena, Kura, Aminu Umar, Fakurazi, Sharida, Hussein, Mohd Zobir

“…A drug active, 6-mercaptopurine (MP) was coated on the surface of Fe3O4-PEG nanoparticles using co-precipitation method in order to form a new magnetic nanocomposite (FPEGMP). …”
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Release behavior and toxicity profiles towards leukemia (WEHI-3B) cell lines 6-mercaptopurine-PEG-coated magnetite nanoparticles delivery systems by Dorniani, Dena, Kura, Aminu Umar, Hussein-Al-Ali, Samer Hasan, Hussein, Mohd Zobir, Fakurazi, Sharida, Shaari, Abdul Halim, Ahmad, Zalinah

“…The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. …”

Development of anti-cancer and anti-hypertensive nanodelivery systems using magnetite iron oxide-polymeric nanoparticles by Dorniani, Dena

“…This may be attributed to the differences in the percentage of 6-mercaptopurine between the two nanocomposites. Also, MP which is loaded into the surface of FNPs-chitosan compared to FNPs-PEG nanocarrier with the same molar ratio, shows better cytotoxicity effect which is due to the role of chitosan. …”
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Pharmacological and toxicological effects of 6-hydroxy-2-mercaptopurine and 6-thioguanine in in vitro and in vivo models of arthritis by Nordin, Nurul Syuhada

“…The thiopurines include 6-mercaptopurine (6-MP), 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG) are the immunosuppressive agents used in the treatment of acute lymphoblastic leukaemia, autoimmune disorders and organ transplant recipients. …”
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