α-mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells via PPARgamma, GLUT4, and leptin expressions by Taher, Muhammad, Mohamed Amiroudine, Mohamed Zaffar Ali, Tengku Zakaria, Tengku Muhamad Faris Syafiq, Deny Susanti, Jauhari Arief Ichwan, Solachuddin, Kaderi, Mohd Arifin, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin

“…Induction of glucose uptake and free fatty acid release by α-mangostin were accompanied by increasing mRNA expression of GLUT4 and leptin. These evidences propose that α-mangostin might be possible candidate for the effective management of obesity in future.…”
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Scopariadulcis (SDF7) endowed with glucose uptake properties on L6 myotubes compared insulin. by Joo, Ee Beh, Latip, Jalifah, Abdullah, Mohd Puad, Ismail, Amin, Hamid, Muhajir

“…Aim of the study Insulin stimulates glucoseuptake and promotes the translocation of glucose transporter 4 (Glut 4) to the plasma membrane on L6myotubes. The aim of this study is to investigate affect of Scopariadulcis Linn water extracts on glucoseuptake activity and the Glut 4 translocation components (i.e., IRS-1, PI 3-kinase, PKB/Akt2, PKC and TC 10) in L6myotubescompared to insulin. …”
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Glucose uptake mechanism of muscle cells and adipocytes stimulated by Scoparia dulcis linn extract by Beh, Joo Ee

“…Furthermore, the expression of Glut 4 protein on the L6 myotubes plasma membrane was confirmed by an immunofluorescence assay. …”
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Comparison of the expression of PI3K/AKT pathway components in type 2 diabetic and non- diabetic human volunteers ex vivo by Khorami, Somayeh Alsadat Hosseini

“…Insulin-stimulated glucose transport occurs via PI3K/AKT-dependent pathway which results in GLUT4 translocation from intracellular vesicles to the plasma membrane and increased glucose uptake. …”
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Vitamins D and E stimulate the PI3K-AKT signalling pathway in insulin-resistant SK-N-SH neuronal cells by Zaulkffali, Amirah Salwani, Md Razip, Nurliyana Najwa, Syed Alwi, Sharifah Sakinah, Abd Jalil, Afifah, Abd Mutalib, Mohd Sokhini, Gopalsamy, Banulata, Chang, Sui Kiat, Zainal, Zaida, Ibrahim, Nafissa Nadia, Zakaria, Zainul Amiruddin, Khaza'ai, Huzwah

“…The combination of vitamins D and E only showed significant increase in GLUT4, p-AKT, reduced ROS as well as GSK3β and TAU. …”
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Anti-diabetic properties and nutrigenomic basis of Curculigo latifolia by Ishak, Nur Akmal, Ismail, Maznah

“…The regulatory effects of C. latifolia fruit:root extracts on genes involved in glucose and lipid metabolisms were further studied on glucose transporter (GLUT 4), peroxisome proliferator-activated receptor (PPARy) and adiponectin receptor (AdipoR1) in skeletal muscle tissue. …”
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Vitamin D and Stimulates the PI3K-AKT signaling pathway in insulin resistant SK-N-SH neuronal cells by Zaulkffali, Amirah Salwani, Md Razip, Nurliyana Najwa, Syed Alwi, Sharifah Sakinah, Abd Jalil, Afifah, Abd Mutalib, Mohd Sokhini, Gopalsamy, Banulata, Chang, Sui Kiat, Zainal, Zaida, Ibrahim, Nafissa Nadia, Zakaria, Zainul Amiruddin, Khaza'ai, Huzwah

“…The combination of vitamins D and E only showed significant increase in GLUT4, p-AKT, reduced ROS as well as GSK3β and TAU. …”
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Nutrigenomic effects of Curculigo latifolia on type 2 diabetic model by Ishak, Nur Akmal, Ismail, Maznah

“…In addition, C. latifolia fruit:root extracts also increased the regulation of GLUT 4 (1 fold), Lep (3 fold) and IRS1 (2 fold) in adipose tissues. …”
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Animal model of gestational diabetes mellitus with pathophysiological resemblance to the human condition induced by multiple factors (nutritional, pharmacological, and stress) in r... by Abdul Aziz, Siti Hajar, John, Cini Mathew, Mohamed Yusof, Nur Intan Saidaah, Nordin, Massita, Ramasamy, Rajesh, Adam, Aishah, Mohd Fauzi, Fazlin

“…Furthermore, low levels of IRS-2 and AKT-1 genes and downregulation of GLUT-4 from the initial to final phases indicate possible defect of insulin signaling. …”
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Understanding the mode-of-action of Cassia auriculata via in silico and in vivo studies towards validating it as a long term therapy for type II diabetes by Fauzi, Fazlin Mohd, John, Cini Mathew, Karunanidhi, Arunkumar, Mussa, Hamse Y., Ramasamy, Rajesh, Adam, Aishah, Bender, Andreas

“…In vivo analysis shows significant increase in the expression of IRS, AKT, GLUT2 and GLUT4 CA may also affect the PPAR-γ signalling pathway. …”
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Methylation and acetylation enhanced the antidiabetic activity of some selected flavonoids: in vitro, molecular modelling and structure activity relationship-based study by Ahmed, Qamar Uddin, Sarian, Murni Nazira, Mat So’ad, Siti Zaiton, Latip, Jalifah, Arief Ichwan, Solachuddin Jauhari, Hussein, Nurlaili Najmie, Taher, Muhammad, Alhassan, Alhassan Muhammad, Hamidon, Hanisuhana, Fakurazi, Sharida

“…Subsequently, protein expressions study through adipokines measurement (leptin, adiponectin, TNF-α, RBP-4) via enzyme-linked immunosorbent assay (ELISA) kit, Western blotting analysis against GLUT4 and C/EBP-α as well as molecular docking against GLUT1 were analyzed. …”
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Influence of dietary polyunsaturated fatty acids on glucose sensitivity, insulin resistance and cognitive function in a rat model by Tan, Ai Li

“…Other than that, PPARα and PPARγ genes were lowly expressed, as well as negligible levels of GLUT4 and GLUT1 readings in the liver and muscle cells. …”
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Role of vitamin D and E in modulating glucose uptake and insulin sensitivity in insulin-resistant neuronal cells by Zaulkffali, Amirah Salwani

“…Insulin treatment significantly reduced the IR, PI3K, GLUT4 and GLUT 3 markers while reduction in AKT phosphorylation and activation of GSK3β were impaired. …”
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Antidiabetic activity of Curculigo latifolia extracts in vitro and in vivo studies by Ishak, Nur Akmal

“…Ten genes; IGF-1, IRS-1, GLUT4,PPARγ, PPARα, AdipoR1, AdipoR2, leptin, lipoprotein lipase and lipase were analyzed using GenomeLab GeXP Genetic Analysis System. …”
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Antidiabetic and hypolipidemic activities of Curculigo latifolia fruit: root extract in high fat fed diet and low dose STZ induced diabetic rats by Ishak, Nur Akmal, Ismail, Maznah, Hamid, Muhajir, Ahmad, Zalinah, Abd Ghafar, Siti Aisyah

“…Furthermore, C. latifolia fruit:root extract significantly increased the expression of IRS-1, IGF-1, GLUT4, PPARα, PPARγ, AdipoR1, AdipoR2, leptin, LPL, and lipase genes in adipose and muscle tissues in diabetic rats. …”
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Genetic determinants of obesity heterogeneity in type II diabetes by Khorami, Somayeh Alsadat Hosseini, Abd Mutalib, Mohd Sokhini, Shiraz, Mohammad Feili, Abdullah, Joseph Anthony, Rejali, Zulida, Mohd Ali, Razana, Khaza'ai, Huzwah

“…Result: In present study, there was no statistically significant difference in gene expression levels of IRS1 and PTEN between groups, whereas PI3K, AKT2 and GLUT4 genes were expressed at a lower level in obese diabetic group compared to other groups and were statistically significant. …”
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In vitro investigation of antidiabetic and antiglycation activities of methanolic extract of Ficus deltoidea Jack varieties by Mohd Dom, Nur Sumirah

“…This study was done to authenticate the antidiabetic property of in vitro antihyperglycemic mechanisms evaluation of F. deltoidea varieties, to elucidate the potential of the plant to stimulate insulin secretion from β-pancreatic cells, to enhance glucose uptake by adipocytes and muscle cells, to screen glucose uptake inhibition activity in adipocytes and muscle cells in the presence of LY294002 (PI3-Kinase inhibitor) and ALLN (CAP inhibitor), to assess the insulin sensitizing activity in adipocytes cells and to observe the expression of PPAR-gamma, PI3 Kinase, GLUT4 and CAP gene. The inhibition of advanced glycation end products formation, protein oxidation, total phenolic contents and antioxidative effects of the plant were also monitored. …”
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Blood glucose response and cellular changes associated with andrographolide treatment in insulin-resistant mice by Abdulameer, Hanaa Abdulabbas

“…In contrast, up regulation of GLUT4, GLUT I, PPARa, PPARy and SREBPs genes expressions. …”
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