Published 2015
“…Although the involvement of Dishevelled in the non-canonical Wnt
signaling pathway is less well studied compared to the canonical pathway, the role of
Dishevelled is also important for cytoskeletal reorganization in planar cell polarity
pathway and promoting tissue separation as well as ventral axis identity in
Xenopus
via the Wnt Calcium pathway. Our hypothesis is that silencing of human Dishevelled
1,2 and 3 isoforms results in inhibition of both canonical and non-canonical Wnt
signaling pathway leading to reduced β-catenin interaction with TCF (T-cell Factor)
and LEF (Lymphoid Enhancer Factor), reduced cell proliferation, migration and also
invasion regardless of canonical or non-canonical Wnt signaling pathway. …”
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Thesis