Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba Pendula) by Maulidiani

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Genotoxicity following organophosphate pesticides exposure among Orang Asli children living in an agricultural island in Kuala Langat, Selangor, Malaysia by Mat Sutris, Juliana, How, Vivien, Sumeri, Siti Arfah, Muhammad, M., Sardi Danori, Mohd Danori, Mohd Mokhtar, M. T., Muhammad, H., Ghazi, Hasanain Faisal, Md Isa, Zaleha

Subjects: “…Organophosphates; Pesticides; Organophosphate poisoning; Mutagenicity tests; Comet assay, Child; Malaysia…”
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Genotoxic effect of Catha edulis (khat) crude extract after sub-chronic administration in rats. by Al-Zubairi, Adel Sharaf, Ismail, Patimah, Chong, Pei Pei, Rahmat, Asmah

“…The alkaline (pH > 13) version of comet assay was used in this study. However, no previous published work has been undertaken and showed the effect of khat on DNA migration in the comet assay. …”
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Biological monitoring of genotoxicity to organophosphate pesticide exposure among rice farmers: exposure-effect continuum study by How, Vivien, Hashim, Zailina, Ismail, Patimah, Md Said, Salmiah, Omar, Dzolkhifli, Mohd Tamrin, Shamsul Bahri

“…Two genotoxic assays (micronuclei and comet assay) were conducted as a biomarker of genotoxic effect among the adult population. …”
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DNA damage and adduct formation in immune organs of developing chicks by polycyclic aromatic hydrocarbons by A. R., Nisha, Hamzah, Hazilawati, Mohd Lila, Mohd Azmi, Mohamed Mustapha, Noordin

“…Comet assay indicated that PAHs especially pyrene, fluoranthene and phenanthrene were capable of inducing increased level of comet parameters in thymus at all the dose levels. …”
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Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? by Eshkoor, Sima Ataollahi, Ismail , Patimah, Abdul Rahman, Sabariah, Moin, Saidi

“…The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei (MN), comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. …”
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Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates by How, Vivien, Hashim, Zailina, Ismail, Patimah, Omar, Dzolkhifli, Md Said, Salmiah, Mohd Tamrin, Shamsul Bahri

“…This is a cross-sectional study conducted among paddy farmers to characterize potential risk factors that influence levels of DNA damage from exposure to mixtures of organophosphates. Comet assay was used to determine the level of DNA damage by measuring the comet tail length from the exfoliated buccal mucosa. …”
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Relationship between learning ability and genotoxicity from organophosphate pesticide exposure among primary school children in Tanjung Karang, Selangor, Malaysia by Miswon, Nurul Husna

“…For genotoxicity assessment, only comet tail length showed significant relationship with blood cholinesterase (p<0.001). …”
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Cytogenetic and Molecular Changes in Buccal Cells from Mechanical Workshop Workers by Eshkoor, Sima Ataollahi

“…GSTM1 polymorphism showed statistically significant effects on MN frequency (p=0.001), comet tail length (p=0.009) and relative telomere length (p=0.025). …”
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Insulinotropic Properties of Several Malaysian Herbs and Ganoderma Species by Bastami, Mohd Saufi

“…Furthermore, Alkaline Comet Assay has proved this toxicity is not due to DNA damage in BRIN-BDl 1 cells. …”
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Biochemical and Mutagenic Effects of 'Khat' (Catha Edulis) in Rats. by Al-Zubairi, Adel Sharaf

“…On the other hand results of DNA damage in the comet assay were observed to show no significant difference between treatment and control groups. …”
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Nephrotoxicopathology properties of gold and iron oxide nanoparticles with Perchloric Acid & SiPEG as radiographic contrast media by Mohamed, Muhamad Idham, Mohammad, Mohd Khairul Amran, Abdul Razak, Hairil Rashmizal, Md Saad, Wan Mazlina

“…Apoptosis detection by TUNEL assay for GNPs and IONPs group also revealed a significant reduction in apoptotic cells compared to iodine group. Comet assay revealed significant reduction in DNA damaging effect of GNPs and IONPs group compared to iodine group. …”
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Hepatotoxic effect of antifungal drugs itraconazole and fluconazole on rats by Yaacob, Azhar

“…Comet assay that been done to detect DNA damage showed that itraconazole caused more DNA damage compared to fluconazole especially at 50 and 100 mg/kg dosing. …”
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Determination of blood cholinesterase, neurobehavioral performance and genetic damage due to organophosphate exposure among male cocoa farmers in Pahang and Perak, Malaysia by Mohammad, Norsyazwani

“…In Sub-study III, the comet tail length values ranged between 12.06 and 35.27 μm (mean: 22.63 μm), whereas the percentage of DNA in the tail ranged between 16.79% and 53.69% (mean: 33.82%). …”
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Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks by Lim, Su Wen, Ting, Kang Nee, Bradshaw, Tracey Dawn, Allaudin, Zeenathul Nazariah, Wiart, Christophe, Khoo, Teng Jin, Lim, Kuan Hon, Loh, Hwei San

“…SCGE comet assays confirmed that plant extracts caused both single strand (SSB) and double strand (DSB) DNA breaks that led to the execution of apoptosis. …”
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Oxidative Dna Damage In Leukocytes And Its Association With Metabolic Control In Diabetic Patients With And Without Microalbuminuria by Sim, Sze Kiat

“…The main aim of this study is to evaluate the extent of oxidative DNA damage with different severity of microalbuminuria in diabetic patients and its associations with other metabolic controls. The comet assay was adopted to measure the level of oxidative DNA damage in leukocytes. …”
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Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children by How, Vivien, Hashim, Zailina, Ismail, Patimah, Md Said, Salmiah, Omar, Dzolkhifli, Mohd Tamrin, Shamsul Bahri

“…The results of micronuclei assay and comet assay showed that the reduced blood cholinesterase level from organophosphate pesticide exposure is significantly associated with an increase in chromosome breakage and DNA strand breaks. …”
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Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review by Abd Rahman, Alia Azwa, Ho, Yu Bin, Nordin, Norshariza, Sin, Eugenie Sing Tan, Abdullah, Rozaini

“…Seven commonly used biomarkers were comet assay parameters, micronucleus (MN), nuclear buds (NBUD), nucleoplasmic bridges (NPB), 8-hydroxy-2-deoxyguanosine (8-OHdG), telomere length, and chromosomal aberrations (CA). …”
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Genotoxicity effects of Newcastle disease virus strain AF2240 in vitro and in vivo by Mohamed Shahrin, Zaid

“…Further studies were carried out to observe the genotoxicity potential of NDV AF2240 using comet assay. In the assay, individual cell was screened for DNA damage after treatment with NDV AF2240. …”
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Potential chemoprevention of primary liver cancer using optimized formulation of Strobilanthus crispus (L.) blume and Centella asiatica L. juices by Hussin, Faridah

“…At more than 0.1% concentration of juices, both Centella asiatica and Strobilanthes crispus showed higher percentage of apoptotic cell death (sub-GI population) than the control HepG2 cells. Comet assay also showed that all cells exhibited a dose-dependent increase in DNA damage compared to controls. …”
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