Evaluation of the effective time for GSK-3 inhibition in experimental autoimmune encephalomyelitis mouse model by tideglusib (NP-12) in preventing neuroinflammation by Al-Zaidi, Ahmed Salam

“…Female C57BL/6 mice were induced with myelin oligodendrocyte glycoprotein (MOG35-55) in conjunction with complete freund's adjuvant (CFA) and pertussis toxin. Inhibition of GSK-3 is performed by the administration of NP-12, a small heterocyclic Thiadiazolidinones (TDZD), intraperitoneally during pre-EAE induction, on the same day, and post-EAE. …”
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