Andrographis Paniculata And Curcuma Xanthorrhiza Extracts And Active Constituents Inhibit Morphine Glucuronidation by Husni, Zulhilmi

“…The inhibitory effects of selected Malaysian medicinal plant herbs namely Andrographis paniculata and Curcuma xanthorrhiza on morphine glucuronidation were evaluated on recombinant UGT2B7 protein and human liver microsomes. Ethanolic and aqueous extracts of Andrographis paniculata as well as andrographolide inhibited morphine glucuronidation at various degrees except for neoandrographolide. …”
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Effects Of Chrysin On The mRNA Expression Of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) And Cyp Genes, Cell Cycle And Cell Migration In Colorectal Cancer Hct-116 Cell... by Khor, Chin Yin

“…Peroxisome proliferator-activated receptor-alpha (PPARα) is reported to regulate the transcription of cytochrome P450 genes in human liver and intestine, which accounts for 70-80% of the enzymes involved in drug metabolism. …”
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Antiproliferative Properties Of Clitoria Ternatea And Vitex Negundo On Cancer Cell Lines by Dashti, Neda Ganjali

“…The major aim of this study was to examine the anti-proliferative activities (IC50 value <100 μg/mL) of water and methanol extracts of both plants against human cancer origin cell lines, namely MCF-7 (hormone-dependent breast cancer cell line), MDA-MB-231 (non-hormone-dependent breast cancer cell line), Caov-3 (human ovary cancer cell line), Hela (human cervical cancer cell line), HepG2 (human liver cancer cell line) and Hs27 (human non-cancer-origin fibroblast cell line). …”
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Aphrodisiac property and anti-tumor agent of eurycoma longifolia jack (Tongkat Ali) by Zakaria, Yusmazura

“…The antiproliferation assay showed the extract inhibited cell proliferation towards human malignant melanoma cell (HM3KO}, human cervical cancer cell (Hela}, human liver cancer cell (HepG2} and human ovarian carcinoma cell (CaOVJ}. …”
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An in vitro study of stereoselectivity of cytochrome p450 enzymes in the metabolism of 3,4-methylenedioxymethamphetamine by Asim, Wan Raihana Wan Aasim @ Wan

“…The in vitro study had three parts: i) determination of MDMA stereoselective protein binding in humans, rats and mice, ii) a correlation analysis study using human liver microsomes (HLM) to determine the effect of inter-individual variations and CYP polymorphisms on MDMA stereoselective metabolism, and iii) enzyme inhibition experiments to study the effects on stereoselectivity. …”
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