Expect analgesic failure; pursue analgesic success. by Moore, A, Derry, S, Eccleston, C, Kalso, E

Mean analgesic consumption is inappropriate for testing analgesic efficacy in post-operative pain: analysis and alternative suggestion. by Moore, R, Mhuircheartaigh, R, Derry, S, McQuay, H

“…CONCLUSION: Because of a highly skewed distribution, post-operative analgesic consumption is an uncertain method of measuring analgesic efficacy of an intervention designed to limit pain during and after surgery.…”

Dynamics of neuronal assemblies are modulated by anaesthetics but not analgesics. by Collins, T, Mann, E, Hill, MR, Dommett, E, Greenfield, S

“… BACKGROUND AND OBJECTIVE: Analgesics and anaesthetics have diverse synaptic actions that nonetheless have a common net inhibitory action on neuronal discharge. …”

Caffeine as an analgesic adjuvant for acute pain in adults. by Derry, C, Derry, S, Moore, R

“… BACKGROUND: Caffeine has been added to common analgesics such as paracetamol, ibuprofen, and aspirin, in the belief that it enhances analgesic efficacy. …”

Pharmacological FMRI in the development of new analgesic compounds. by Schweinhardt, P, Bountra, C, Tracey, I

“…We are therefore optimistic that phFMRI will be used as a tool with high sensitivity and specificity for evaluating analgesic agents in early drug development and clinical studies.…”

Evidence for analgesic effect in acute pain - 50 years on. by McQuay, H, Derry, S, Eccleston, C, Wiffen, P, Andrew Moore, R

Potent, selective adenosine Al agonists as potential analgesics by Beswick, P, Bountra, C, Clayton, N, Collins, S, Cousins, R, Eldred, C, Naylor, A, Sheehan, M, Spalding, D

Evidence for analgesic effect in acute pain - 50 Years on by McQuay, H, Derry, S, Eccleston, C, Wiffen, P, Andrew Moore, R

Neuroimaging as a tool for pain diagnosis and analgesic development by Wartolowska, K, Tracey, I

“…Moreover, neuroimaging shows promising results for analgesic drug development and in characterizing different types of pain, bringing us closer to development of mechanism-based diagnoses and treatments for the chronic pain patient.…”

Potent analgesic effects of GDNF in neuropathic pain states. by Boucher, T, Okuse, K, Bennett, D, Munson, J, Wood, J, McMahon, S

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…BACKGROUND: Thirty-five Cochrane Reviews of randomised trials testing the analgesic efficacy of individual drug interventions in acute postoperative pain have been published. …”

UK legislation on analgesic pack sizes: impact on suicidal behaviour by Hawton, K, Townsend, E

Nociceptive brain activity as a measure of analgesic efficacy in infants by Hartley, C, Duff, E, Green, G, Schmidt Mellado, G, Worley, A, Rogers, R, Slater, R

“…Here, we present an EEG-based measure of infant nociceptive brain activity that is evoked following acute noxious stimulation and is sensitive to analgesic modulation. This measure will be valuable for both mechanistic investigations and for testing analgesic efficacy in the infant population.…”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Thirty-five Cochrane Reviews of randomised trials testing the analgesic efficacy of individual drug interventions in acute postoperative pain have been published. …”

Impact of withdrawal of the analgesic Co-proxamol on nonfatal self-poisoning in the UK. by Hawton, K, Bergen, H, Waters, K, Murphy, E, Cooper, J, Kapur, N

“…BACKGROUND: In early 2005 the UK Committee on Safety of Medicines (CSM) announced gradual withdrawal of the analgesic co-proxamol because of its adverse benefit/safety ratio, especially its use for intentional and accidental fatal poisoning. …”

Chronic low back pain analgesic studies--a methodological minefield. by Moore, R, Straube, S, Derry, S, McQuay, H

The use of locomotor activity equipment to assess analgesic and anti-inflammatory activity by Thompson, S, Clayton, N, Oakley, I, Bountra, C

Opioid analgesic dependence: where do we go from here? by Quinlan, J, Knox, K

Lost but making progress--Where will new analgesic drugs come from? by Borsook, D, Hargreaves, R, Bountra, C, Porreca, F

“…The paucity of new drugs successfully reaching the clinic calls for a reassessment of current analgesic drug discovery approaches. Many points early in the discovery process present significant hurdles, making it critical to exploit advances in pain neurobiology to increase the probability of success. …”

The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. by Bingel, U, Wanigasekera, V, Wiech, K, Ni Mhuircheartaigh, R, Lee, M, Ploner, M, Tracey, I

“…We investigated how divergent expectancies alter the analgesic efficacy of a potent opioid in healthy volunteers by using brain imaging. …”