The effect of isoliquiritigenin on the hERG potassium channel by Mujahid, M, Wang, T, Ellory, C, Wilkins, R, Ma, Y-L

Rapid characterisation of hERG channel kinetics II: temperature dependence by Lei, CL, Clerx, M, Beattie, KA, Melgari, D, Hancox, JC, Gavaghan, DJ, Polonchuk, L, Wang, K, Mirams, GR

“…In this Part II, we use this protocol to study the temperature dependence of hERG kinetics using Chinese hamster ovary cells overexpressing hERG1a on the Nanion SyncroPatch 384PE, a 384-well automated patch-clamp platform, with temperature control. …”

Contributions of HERG K+ current to repolarization of the human ventricular action potential. by Fink, M, Noble, D, Virag, L, Varro, A, Giles, W

“…For these reasons we and others have attempted to define the functional role for HERG-mediated K+ currents in repolarization of the action potential in the human ventricle. …”

Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols by Beattie, K, Bardenet, R, Louttit, J, Vandenberg, J, Hill, A, Gavaghan, D, De Boer, T, Mirams, G

“…Drug block of the hERG channel is a primary focus of existing cardiac proarrhythmic safety assessment strategies. hERG plays a fundamental role in repolarization of the cardiac action potential and block of this channel can lead to prolongation of, and morphological changes to, the cardiac action potential, which are implicated in increasing proarrhythmic risk. …”

Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system by Lei, CL, Clerx, M, Gavaghan, D, Polonchuk, L, Mirams, GR, Wang, K

“…We demonstrate its use on the Nanion SyncroPatch 384PE, a 384-well automated patch-clamp platform, by applying it to Chinese hamster ovary cells stably expressing hERG1a. From these recordings, we construct 124 cell-specific variants/parameterizations of a hERG model at 25°C. …”

Modelling effects of Sotalol on Action Potential morphology using a novel Markov model of the HERG channel by Brennan, T, Fink, M, Rodriguez, B, Tarassenko, L

The faint source population at 15.7 GHz – III. A high-frequency study of HERGs and LERGs by Whittam, I, Riley, J, Green, D, Jarvis, M

“…Optical spectra are used to classify 17 of the sources as high-excitation or low-excitation radio galaxies (HERGs and LERGs, respectively), for the remaining sources three other methods are used; these are optical compactness, X-ray observations and mid-infrared colour-colour diagrams. 32 sources are HERGs and 35 are LERGs while the remaining 29 sources could not be classified. …”

Application of Human Stem Cell−derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG by Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, de Boer, T, van Veen, T

“…The only compound that triggered EADs was hERG blocker Cisapride. Computer simulations and APclamp showed that the immature AP of hESC-CM prevents proper functioning of INa-channels, and result in lower peak/maximal currents of several other channels, compared to the adult situation. …”

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG by Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, De Boer, T, Van Veen, T

“…The only compound that triggered EADs was hERG blocker Cisapride. Computer simulations and AP clamp showed that the immature AP of hESC-CM prevents proper functioning of I Na-channels, and result in lower peak/maximal currents of several other channels, compared to the adult situation. …”

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. by Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, de Boer, T, van Veen, T

“…The only compound that triggered EADs was hERG blocker Cisapride. Computer simulations and AP clamp showed that the immature AP of hESC-CM prevents proper functioning of I(Na)-channels, and result in lower peak/maximal currents of several other channels, compared to the adult situation. …”

Modelling effects of Sotalol on Action Potential morphology using a novel Markov model of the HERG channel by Brennan, T, Fink, M, Rodriguez, B, Tarassenko, LT

The faint source population at 15.7 GHz - III. A high-frequency study of HERGs and LERGs by Whittam, I, Riley, J, Green, D, Jarvis, M

“…Optical spectra are used to classify 17 of the sources as high-excitation or low-excitation radio galaxies (HERGs and LERGs respectively), for the remaining sources three other methods are used; these are optical compactness, X-ray observations and mid-infrared colour--colour diagrams. 32 sources are HERGs and 35 are LERGs while the remaining 29 sources could not be classified. …”

HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance by Bueno−Orovio, A, Orini, M, Hanson, B, Hayward, M, Taggart, P, Lambiase, P, Burrage, K, Rodriguez, B

Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment by Farm, HJ, Clerx, M, Cooper, F, Polonchuk, L, Wang, K, Gavaghan, DJ, Lei, CL

“…Here, we study the impact of including state-dependent drug binding in a mathematical model of hERG when translating hERG inhibition to action potential changes. …”

A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study by Paci, M, Passini, E, Severi, S, Hyttinen, J, Rodriguez, B

The link between accretion mode and environment in radio-loud active galaxies by Ineson, J, Croston, J, Hardcastle, M, Kraft, R, Evans, D, Jarvis, M

“…Comparing the samples, we found that although the maximum environment richness of the HERG environments is similar in both samples, there are poorer HERG environments in the z~0.1 sample than in the z~0.5 sample. …”

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk by Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D

“…While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold of their hERG inhibitory concentration 50% (IC50) values has been suggested, there are drugs that are exceptions to this rule: hERG inhibitors that do not cause TdP, and drugs that can cause TdP but are not strong hERG inhibitors. …”

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. by Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D

“…While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold of their hERG inhibitory concentration 50% (IC(50)) values has been suggested, there are drugs that are exceptions to this rule: hERG inhibitors that do not cause TdP, and drugs that can cause TdP but are not strong hERG inhibitors. …”

The Stripe 82 1–2 GHz Very Large Array Snapshot Survey: host galaxy properties and accretion rates of radio galaxies by Whittam, I, Prescott, M, McAlpine, K, Jarvis, M, Heywood, I

“…Optical spectra are used to classify these sources as high excitation and low excitation radio galaxies (HERGs and LERGs), resulting in 60 HERGs, 149 LERGs, and 600 ‘probable LERGs’. …”

The radio galaxy population in the SIMBA simulations by Thomas, N, Jarvis, MJ, Davé, R, Anglés-Alcázar, D

“…SIMBA thus predicts that deeper radio surveys will reveal an increasing overlap between the host galaxy demographics of HERGs and LERGs.…”