Opportunity Knocks? The Possibilities and Levers for Improving Job Quality by Findlay, P, Warhurst, C, Keep, E, Lloyd, C

Knock-out and transgenic mouse models of tauopathies. by Denk, F, Wade-Martins, R

“…Here we review the range of Mapt knock-out and MAPT transgenic mouse models which have proven successful at providing insights into the molecular mechanisms of neurodegenerative disease. …”

Knock measurement for fuel evaluation in spark ignition engines by Hudson, C, Gao, X, Stone, R

Increasing knock-in efficiency in mouse zygotes by transient hypothermia by Bouchareb, A, Biggs, D, Alghadban, S, Preece, C, Davies, B

“…Taken together, our data suggest that a transient cold shock could offer a simple and robust way to improve knock-in outcomes in both stem cells and zygotes. …”

Transcriptional analysis of chIFITM knock-out cell lines by Hadrovic-Sinthalapadi, M

“…Here I hypothesise that <i>chIFITM</i> knock-out models could support higher viral titres due to the ablation of <i>chIFITM</i> genes. …”

DEVELOPMENT AND CHARACTERISATION OF A NOVEL KNOCK-IN MODEL OF PRKAG2 CARDIOMYOPATHY by Yavari, A, Pinter, K, Ashrafian, H, Redwood, C, Watkins, H

The effect of combustion knock on the instantaneous heat flux in spark ignition engines by Stone, C, Mutzke, J, Williams, J, Scott, B

Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7. by Kessler, B, Fortunati, E, Melis, M, Pals, C, Clevers, H, Maurice, M

Gene Correction of a Duchenne Muscular Dystrophy Mutation by Meganuclease-Enhanced Exon Knock-In by Popplewell, L, Koo, T, Leclerc, X, Duclert, A, Mamchaoui, K, Gouble, A, Mouly, V, Voit, T, Pâques, F, Cédrone, F, Isman, O, Yáñez-Muñoz, R, Dickson, G

Knocking out pain in livestock: can technology succeed where morality has stalled? by Shriver, A

Knock-down of ELMO1 in paediatric Rhabdomyosarcoma cells by nanoparticle mediated siRNA delivery by Huang, X, Townley, H

“…The ARMS subtype has higher rates of metastasis, as well as higher levels of ELMO1, which is thought to be involved in cell migration. Therefore, the knock-down of ELMO1 by targeted siRNA could provide a mechanism to prevent the metastatic behaviour of ARMS cells. …”

Utrophin luciferase knock-in mouse model for in vivo assessment of drug efficacy in preclinical trials for utrophin upregulation by Fairclough, R, Davies, K

Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. by Tuoc, T, Radyushkin, K, Tonchev, AB, Piñon, M, Ashery-Padan, R, Molnár, Z, Davidoff, MS, Stoykova, A

Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice. by Piñon, M, Tuoc, T, Ashery-Padan, R, Molnár, Z, Stoykova, A

“…Herein, we analyzed the role of Pax6 in molecular arealization and development of thalamocortical connections in the juvenile cortex-specific conditional Pax6 knock-out mice (Pax6cKO). Using a set of molecular markers of positional identity (Id2, Cadherin6, COUP-TF1, RZRbeta, and EphA7), we show that, in the juvenile Pax6cKO, the relative size of caudal cortical areas (putative visual and somatosensory) are mildly enlarged, whereas the rostral domain (putative motor) is severely reduced. …”

MODELLING CALCIUM HANDLING MECHANISMS IN NORMAL AND NEURONAL NITRIC OXIDE SYNTHASE KNOCK-OUT MOUSE HEARTS by Li, L, Niederer, SA, Idigo, W, Zhang, Y, Casadei, B, Smith, N

Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. by Sakura, H, Ashcroft, S, Terauchi, Y, Kadowaki, T, Ashcroft, F

“…Glucose fails to stimulate insulin secretion in mice in which the glucokinase gene has been selectively knocked out in the beta cell. We tested the hypothesis that this effect results from defective metabolic regulation of beta cell ATP-sensitive potassium (K(ATP)) channels. …”

Rescue of secretion of rare-disease associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells by Tax, G, Guay, K, Pantalone, L, Ceci, M, Soldà, T, Hitchman, C, Hill, J, Vasiljevic, S, Lia, A, Modenutti, C, Straatman, K, Santino, A, Molinari, M, Zitzmann, N, Hebert, D, Roversi, P, Trerotola, M

Imaging synaptic vesicles using VGLUT1-venus knock-in mice: insights into the dynamic nature of intersynaptic vesicle exchange. by Padamsey, Z, Jeans, A

DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact by Rawlings-Mortimer, F, Gullino, LS, Rühling, S, Ashton, A, Barkus, C, Johansen-Berg, H

“…Here, we assess whether Dusp15 is reduced in the hippocampus of mice with conditional knock-out of Myrf in oligodendrocyte precursor cells. …”

The pyrethroid knock-down resistance gene in the Anopheles gambiae complex in Mali and further indication of incipient speciation within An. gambiae s.s. by Fanello, C, Petrarca, V, della Torre, A, Santolamazza, F, Dolo, G, Coulibaly, M, Alloueche, A, Curtis, C, Touré, Y, Coluzzi, M

“…The population structure of An. gambiae s.l. was analysed in three villages in the Bamako and Sikasso areas of Mali and the frequency of pyrethroid resistance of the knock-down resistance (kdr) type was calculated. …”