Meeting report of the 13th Congress of the International Society of Vascularized Composite Allotransplantation by Weissenbacher, A, Cendales, L, Morelon, E, Petruzzo, P, Brandacher, G, Friend, P, Gorantla, V, Kaufman, C, Krapf, J, Levin, L, Vrakas, G, Schneeberger, S

“…<p style="text-align:justify;">The International Society of Vascularized Composite Allotransplantation held its 13th congress “Defining Success” in October 2017 in Salzburg, Austria. …”

Pre-transplant management and sensitisation in vascularised composite allotransplantation: A systematic review by Geoghegan, L, Al-Khalil, M, Scarborough, A, Murray, A, Issa, F

“…<p><strong>Introduction</strong> Vascularised composite allotransplantation (VCA) permits like-for-like reconstruction following extensive soft tissue injuries. …”

Management of endocrine disease: Postsurgical hypoparathyroidism: current treatments and future prospects for parathyroid allotransplantation by Mihai, R, Thakker, RV

“…Based on recent case reports of successful allotransplantation of parathyroid tissue between siblings, there is renewed interest in this technique. …”

IN VIVO ENRICHMENT OF REGULATORY T CELLS BY BCL-2/BCL-XL INHIBITION PROMOTES TOLERANCE IN ALLOTRANSPLANTATION by Gabriel, S, Bon, N, Chen, J, Kraus, A, Bushell, A, Fehr, T, Cippa, P

Modelling and characterisation of in vivo human skin graft rejection for the investigation of regulatory T cell therapy in vascularised composite allotransplantation by Issa, F

Metabolic effects of restoring partial beta-cell function after islet allotransplantation in type 1 diabetic patients. by Luzi, L, Perseghin, G, Brendel, MD, Terruzzi, I, Battezzati, A, Eckhard, M, Brandhorst, D, Brandhorst, H, Friemann, S, Socci, C, Di Carlo, V, Piceni Sereni, L, Benedini, S, Secchi, A, Pozza, G, Bretzel, R

De novo donor‐specific HLA antibodies after combined intestinal and vascularized composite allotransplantation — a retrospective study by Weissenbacher, A, Vrakas, G, Chen, M, Reddy, S, Allan, P, Giele, H, Barnardo, M, Vaidya, A, Friend, P, Fuggle, S

“…Combining vascularized composite allotransplantation (VCA) with intestinal transplantation to achieve primary abdominal closure has become a feasible procedure. …”

Synergistic effect of low dose cyclosporine A and human interleukin 10 overexpression on acute rejection in rat lung allotransplantation. by Pierog, J, Gazdhar, A, Stammberger, U, Gugger, M, Hyde, S, Mathiesen, I, Grodzki, T, Schmid, R

“…CONCLUSIONS: Electroporation mediated hIL-10 overexpression in a peripheral muscle of the recipient in combination with low dose CsA reduces acute rejection in this model of rat lung allotransplantation.…”

Pancreatic islet transplantation. by Johnson, P, Jones, K

“…However, as the procedure involves the transplantation of the patient's own islets, and the indication for the procedure is not for autoimmune disease, there are none of the difficult immune challenges of allotransplantation.…”

Physiological aspects of xenotransplantation by Soin, B, Friend, P

“…Increasing efforts are being directed at providing solutions to the shortage of organs for allotransplantation. The immunological and infectious barriers to the use of xenografts have been extensively studied. …”

Humanization of immunodeficient animals for the modeling of transplantation, graft versus host disease and regenerative medicine by Adigbli, G, Ménoret, S, Cross, AR, Hester, J, Issa, F, Anegon, I

“…In this review, the immune and tissue humanization of various species is presented with an emphasis on their potential for use as models for allotransplantation, graft versus host disease and regenerative medicine.…”

An investigation of regulatory T cell therapy in advanced human skin experimental transplantation models by Adigbli, G

“…</p> <p>The two aims of this study were to develop an advanced humanised mouse model that could support multilineage human haematopoeisis and accurately represent human allotransplantation, and to investigate whether specific skin-homing human Treg subsets can provide effective anti-rejection therapy for skin allografts.…”

Isolation of adult porcine islets of Langerhans. by Toso, C, Brandhorst, D, Oberholzer, J, Triponez, F, Bühler, L, Morel, P

“…While human islet allotransplantation is limited due to the shortage of donors, pig islet xenotransplantation appears to be a possible alternative. …”

Physiological aspects of pig-to-primate renal xenotransplantation. by Soin, B, Smith, K, Zaidi, A, Cozzi, E, Bradley, JR, Ostlie, D, Lockhart, A, White, D, Friend, P

“…In contrast to allotransplantation a severe anaemia developed requiring recipient treatment with exogenous human erythropoietin. …”

An immune atlas of T cells in transplant rejection: pathways and therapeutic opportunities by Short, S, Lewik, G, Issa, F

“…<p>Short-term outcomes in allotransplantation are excellent due to technical and pharmacological advances however, improvement in long-term outcomes has been limited. …”

Functional impairment of cytomegalovirus specific CD8 T cells predicts high-level replication after renal transplantation. by Mattes, F, Vargas, A, Kopycinski, J, Hainsworth, E, Sweny, P, Nebbia, G, Bazeos, A, Lowdell, M, Klenerman, P, Phillips, R, Griffiths, P, Emery, VC

“…Human cytomegalovirus (HCMV) remains an important cause of morbidity after allotransplantation, causing a range of direct effects including hepatitis, pneumonitis, enteritis and retinitis. …”

Investigation of the cell biology of human regulatory T cells in the context of transplantation by Milward, K

“…After infusing labelled cells into a humanised mouse model of skin allotransplantation, we detected human Tregs within a human skin graft by PCR and visualised Tregs moving in the graft, in a live mouse, by two-photon microscopy.…”

Prolonged amelioration of acute lung allograft rejection by overexpression of human interleukin-10 under control of a long acting ubiquitin C promoter in rats. by Stammberger, U, Bilici, M, Gugger, M, Gazdhar, A, Hamacher, J, Hyde, S, Schmid, R

“…METHODS: Left lung allotransplantation was performed from Brown-Norway to Fischer-F344 rats. …”