Boronic acid and nitrofuranyl derivatives as potential therapeutics by Dey, AL

“…Attention is particularly directed to the second half of Chapter 2 in which the Design & Synthesis of novel polyfunctional DCC ligands is thoroughly discussed with a fuller discussion on their DCC systems with 2-formylphenyl boronic acid & formaldehyde which led to identification of novel and intriguing heterocycles. …”

Arylsulfonyl fluoride boronic acids: preparation and coupling reactivity by Lou, TS-B, Willis, MC

“…The boronic acids undergo efficient Sukuki-Miyaura coupling reactions with a range of aryl halides. …”

Boronic acid catalyzed ene carbocyclization of acetylenic dicarbonyl compounds. by Li, M, Yang, T, Dixon, D

B-11 NMR-STUDIES OF AN ARYL BORONIC ACID BOUND TO CHYMOTRYPSIN AND SUBTILISIN by Baldwin, J, Claridge, T, Derome, A, Schofield, C, Smith, B

“…The binding of aryl boronic acids to α-chymotrypsin and subtilisin has been studied by 11B NMR spectroscopy; evidence is provided for the direct spectroscopic observation of a tetrahedral enzyme/boromate complex. © 1991.…”

Highly enantioselective rhodium-catalyzed cross-coupling of boronic acids and racemic allyl halides by González, J, Van Dijk, L, Goetzke, F, Fletcher, S

“…The method couples racemic allyl halide starting materials with sp2-hybridized boronic acid derivatives and is compatible with heterocyclic coupling partners. …”

Single-molecule determination of the isomers of D-glucose and D-fructose that bind to boronic acids by Ramsay, W, Bayley, H

“…Monosaccharides, such as D-glucose and D-fructose, exist in aqueous solution as an equilibrium mixture of cyclic isomers and can be detected with boronic acids by the reversible formation of boronate esters. …”

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. by Demetriades, M, Leung, I, Chowdhury, R, Chan, M, McDonough, M, Yeoh, K, Tian, Y, Claridge, T, Ratcliffe, P, Woon, E, Schofield, C

“…Dynamic duo: The reversible reaction of boronic acids with alcohols to form boronate esters, coupled to protein mass spectrometry analyses, was used to discover potent oxygenase inhibitors. …”

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases by Inglis, SR, Strieker, M, Rydzik, A, Dessen, A, Schofield, C

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases. by Inglis, SR, Strieker, M, Rydzik, A, Dessen, A, Schofield, C

“…We report the development of a fluorescence polarization (FP) assay for PBPs and "serine" β-lactamases using a boronic-acid-based, reversibly binding "tracer." The tracer was designed based on a crystal structure of a covalent complex between a boronic acid and PBP1b from Streptococcus pneumoniae. …”

Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride by Sap, J, Wilson, T, Kee, C, Straathof, N, Ende, C, Mukherjee, P, Zhang, L, Genicot, C, Gouverneur, V

DIRECT OBSERVATION OF A TETRAHEDRAL BORONIC ACID BETA-LACTAMASE COMPLEX USING B-11 NMR-SPECTROSCOPY by Baldwin, J, Claridge, T, Derome, A, Smith, B, Twyman, M, Waley, S

“…A tetrahedral boronic acid-β-lactamase complex formed by treatment of the P99 β-lactamase enzyme from Enterobacter cloacae with 3-dansylamidophenylboronic acid has been directly observed using 11B NMR spectroscopy.…”

Nickel(II)-catalyzed synthesis of sulfinates from aryl and heteroaryl boronic acids and the sulfur dioxide surrogate DABSO by Willis, M, Lo, P, Chen, Y

Carbon-carbon bond construction using boronic acids and aryl methyl sulfides: orthogonal reactivity in Suzuki-type couplings by Hooper, J, Young, R, Pernik, I, Weller, A, Willis, M

“…The Rh(i)-catalysed coupling of aryl and alkenyl boronic acids with simple aryl and alkenyl methyl sulfides is reported. …”

Palladium(II)-catalyzed synthesis of sulfinates from boronic acids and DABSO: a redox-neutral, phosphine-free transformation by Deeming, AS, Russell, CJ, Willis, MC

“…A redox-neutral palladium(II)-catalyzed conversion of aryl, heteroaryl, and alkenyl boronic acids into sulfinate intermediates, and onwards to sulfones and sulfonamides, has been realized. …”

Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride by Zhao, Q, Isenegger, PG, Wilson, TC, Sap, JBI, Guibbal, F, Lu, L, Gouverneur, V, Shen, Q

“…Herein, we report a mild and practical protocol for the copper-catalyzed chlorofluoromethylthiolation of (hetero)aryl boronic acids with the novel reagent PhSO2SCFClH. The resulting products are amenable to halogen exchange 18F-fluorination with cyclotron-produced [18F]fluoride affording [18F]ArSCF2H. …”

Sequential catalysis: Exploiting a single rhodium(I) catalyst to promote an alkyne hydroacylation–aryl boronic acid conjugate addition sequence by Fernández, M, Castaing, M, Willis, M

“…We demonstrate that a single Rh(I) complex can promote two mechanistically distinct C-C bond-forming reactions – alkyne hydroacylation and aryl boronic acid conjugate addition – to deliver substituted ketone products from the controlled assembly of three readily available fragments. …”

Enantioselective three-component assembly of β’-aryl-enones using a rhodium-catalyzed alkyne hydroacylation/aryl boronic acid conjugate addition sequence by Gao, M, Willis, M

“…The sequence corresponds to the formal regio- and enantioselective mono-conjugate addition of aryl boronic acids to dienones.…”

Ketone synthesis via rhodium-catalyzed traceless chelation-controlled hydroacylation reactions by Gao, M

“…</p> <p><strong>Chapter 2</strong> describes a sequential reaction involving alkene hydroacylation, sulfide elimination and boronic acid conjugate addition, which affords products with the initial sulfide coordinating group replaced by a stereochemically defined aryl group.…”

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. by Inglis, SR, Zervosen, A, Woon, E, Gerards, T, Teller, N, Fischer, D, Luxen, A, Schofield, C

“…Here we report aromatic boronic acid inhibitors of the D,D-carboxypeptidase R39 from Actinomadura sp. strain. …”

Arylations mediated by lead(IV) in the presence of formazan and imine ligands by Iqbal, A, Moloney, M, Siddiqui, H, Thompson, A

“…The use of formazan and imine ligands in arylations of β-dicarbonyl systems by phenyl boronic acid/lead(IV) carboxylates is examined. © 2009 Elsevier Ltd. …”