8-OxoA inhibits the incision of an AP site by the DNA glycosylases Fpg, Nth and the AP endonuclease HAP1. by Lomax, M, Salje, H, Cunniffe, S, O'Neill, P

“…This study demonstrates that the initial stages of base excision repair can be impaired by the presence of a second base lesion in proximity to an AP site on the same DNA strand. …”

On the computation of lambda-contractive sets for linear constrained systems by Schulze Darup, M, Cannon, M

“…First, we show that it is possible to a priori compute a number of iterations that is sufficient to approximate the maximal λ-contractive set with a given precision using 1-step sets. Second, based on the former result, we provide a procedure for choosing λ so that the associated maximal λ-contractive set is guaranteed to approximate the maximal controlled invariant set with a given accuracy.…”

Consumers’ Categorization Processes: An Examination with Two Alternative Methodological Paradigms by Basu, K

“…Two methodological paradigms were employed, the first involving the outcome of categorization judgments made by consumers for unfamiliar products/brands. The second, based on the retrieval of exemplars acquired during category learning and verification of their match with the target, was subjected to its first empirical examination. …”

Spatial approaches to assignment by Pouncett, J

“…Two approaches are outlined – the first based on the calculation of residuals, and the second based on Bayesian statistics and maximum likelihood estimation. …”

The skeleton: Connecting large scale structures to galaxy formation by Pichon, C, Gay, C, Pogosyan, D, Prunet, S, Sousbie, T, Colombi, S, Slyz, A, Devriendt, J

“…The first, based on a global study of the matter density gradient flow, allows us to study the connectivity between a density peak and its surroundings, with direct relevance to the anisotropic accretion via cold flows on galactic halos. From the second, based on a local constraint equation involving the derivatives of the field, we can derive predictions for powerful statistics, such as the differential length and the relative saddle to extrema counts of the Cosmic web as a function of density threshold (with application to percolation of structures and connectivity), as well as a theoretical framework to study their cosmic evolution through the onset of gravity-induced non-linearities. © 2010 American Institute of Physics.…”

The Skeleton: Connecting Large Scale Structures to Galaxy Formation by Pichon, C, Gay, C, Pogosyan, D, Prunet, S, Sousbie, T, Colombi, S, Slyz, A, Devriendt, J

“…The first, based on a global study of the matter density gradient flow, allows us to study the connectivity between a density peak and its surroundings, with direct relevance to the anisotropic accretion via cold flows on galactic halos. From the second, based on a local constraint equation involving the derivatives of the field, we can derive predictions for powerful statistics, such as the differential length and the relative saddle to extrema counts of the Cosmic web as a function of density threshold (with application to percolation of structures and connectivity), as well as a theoretical framework to study their cosmic evolution through the onset of gravity-induced non-linearities.…”

Hybrid water rights systems for pro-poor water governance in Africa by Schreiner, B, van Koppen, B

“…The present study aimed to, first, further understand the implications of permit systems for both the most vulnerable and the state, and, second, based on the findings, identify options for pro-poor water legislation that also meet the water governance requirements of the state. …”

Dynamic spectrum sharing for future wireless communications by Jiang, X

“…</p> <p>Firstly, based on the coordinated DSS model, this thesis proposes a heterogeneous-prioritized spectrum sharing policy for coordinated dynamic spectrum access networks. Secondly, based on the uncoordinated DSS model, a novel partial spectrum sharing strategy and the cross-layer optimization method have been proposed to achieve efficient spectrum sharing between two licensed networks. …”

Putting the foot down: accelerating EV uptake in Kyrgyzstan by Kondev, B, Dixon, J, Zhou, Z, Sabyrbekov, R, Sultanaliev, K, Hirmer, SA

“…Firstly, we present an investigation of the policy and institutional landscape relating to transport and the promotion of EVs in Kyrgyzstan. Secondly, based on research of 50,000 car sales and interviews with 23 key stakeholders in the country, we present analysis of the existing Kyrgyz vehicle fleet. …”

A disaster response system based on human-agent collectives by Ramchurn, S, Huynh, T, Wu, F, Ikuno, Y, Flann, J, Moreau, L, Fischer, J, Jiang, W, Rodden, T, Simpson, E, Reece, S, Roberts, S, Jennings, N

“…First, they have to develop an understanding of the unfolding event either using their own resources or through third-parties such as the local population and agencies. Second, based on the information gathered, they need to deploy their teams in a flexible manner, ensuring that each team performs tasks in the most effective way. …”

Internationalization of the curriculum in Japanese universities: an investigation of English medium instruction and collaborative online international learning programs by Radjai, L, Hammond, C

“…This working paper is thus comprised of two parts; the first reports on research focused on IoC in EMI contexts in Japanese higher education, and the second, based on notable emergent findings from the first study, looks more specifically at COIL programs. …”

On the origin, progression, and evolution of ovarian cancer by KaramiNejadRanjbar, M

“…Analysing the results using DigiTitan and MutLX, firstly, I introduced tumour heterogeneity and genetic diversity as a hallmark of HGSOC. Secondly, based on new observations from this study, I challenged a pre-existing notion that mutations in TP53 gene are responsible for the initiation of HGSOC. …”

Perinatal outcomes in treated, HIV-positive pregnant women by Santosa, WB

“…Among treated HIV-positive women: 1) highly active antiretroviral therapy (HAART) was associated with PTB, LBW and SGA; 2) protease inhibitor (PI)-based ART was associated with PTB, and 3) pre-conception initiation of ART was associated with PTB and VPTB. Secondly, based on accurately determined gestational age and birth weight in the longitudinal study, the overlap between PTB and LBW was substantial, i.e. it is not worthwhile to analyse them separately. …”