Cardiogenic shock - novelty and emerging therapeutic concepts by I. Petrov, Z. Stankov, S. Vasilev

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Impairments of haemostasis and therapeutic management in patients with COVID-19 by Zheina Cherneva, Radostina Cherneva

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Therapeutic options in the treatment of infectious endocarditis of an implantable cardiac device lead by M. Ivanov, M. Peneva, I. Ivanov, N. Gotcheva, L. Boyadzhiev

“…These cases pose signifi cant therapeutic challenges, especially when right-sided devices are involved. …”
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Тhe uncharted middle ground – when the patient asks, but the guideliness don’t answer by Iskra Bayraktarova, Tzvetana Katova

“…The accumulation of knowledge about the range of phenotypes and the therapeutic responses across the spectrum of heart failure leads to dynamic reconsideration of the best classifi cation schemes and also of the offi cially recommended therapeutic guidelines. …”
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Angiography in patients with congenital heart defects by Kiparisiya Nenova

“…Imaging modalities are an important part of the diagnostic and therapeutic process in patients with congenital heart defects (CHD) - operated and non-operated. …”
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Infectious endocarditis – current profile by B. Dobreva-Yatseva, F. Nikolov, R. Raycheva, M. Tokmakova

“…Early identification of high-risk patients is important for the therapeutic approach, especially when deciding on operative treatment. …”
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Complete interventional revascularization versus infarct-related artery revascularization only in SТЕМI patients – part I by Iskra Bayraktarova, Elina Trendafilova

“…Optimal therapy of the infarct-related lesion has been largely elucidated and is stipulated in current guideline documents. Therapeutic options for the additional lesions are a subject of active debate and clinical trial worldwide – both the target degree of revascularization and its timing in relation to the index procedure remain unclear.…”
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Serum biomarkers for pulmonary hypertension by Ts. Boneva, R. Ivanova, G. Zlatantcheva, D. Vasilev, K. Karamfiloff

“…In the fi eld of development of pathophysiology of pulmonary hypertension, there are growing number of signifi cant recent advances, which leads to new therapeutic agents. Traditional methods of diagnosing and monitoring this condition have comprised echocardiography and right heart catheterization, in addition to functional measures, such as estimation of functional class and the 6-min walk test. …”
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Clinical significance and change in the degree of mitral insufficiency after TAVI by D. Trendafilova, J. Djorgova, H. Varnaliyska, N. Naidenova, R. Stoycheva, R. Valchev, H. Angelov

“…Despite the establishment of the method as a standard in the treatment of high-risk patients for surgery worldwide and the growing number of patients treated interventionally, behavior in concomitant signifi cant MR continues to be a diagnostic and therapeutic challenge. The decision to intervene on multiple valves must take into account the additional surgical risk of the combined procedures. …”
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What are the novelties in acute heart failure? by Yoto Yotov

“…Basic and newer diagnostic methods are considered in this review to help the medical professionals in fi nding the exact reason for dyspnea and to defi ne patients at increased risk of adverse outcomes. The therapeutic possibilities for managing AHF in recent years with their successes and failures are discussed. …”
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Massive lipomatous hypertrophy of the interatrial septum and the wall of the right atrium mimicking a cardiac tumor (myxoma) by R. Georgiev, S. Bakalska-Georgieva, A. Angelov

“…With the help of double and triple inversion techniques, magnetic resonance imaging can give a tissue-specific diagnosis, in this case a fat-equivalent lesion of the type of lipoma or lipomatous hypertrophy, and thus save additional studies and predetermine the therapeutic approach.…”
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Novel approaches to treat resistant hypertension by Aleksandra Cherneva, Ivo Petrov

“…Among these new methods of treatment, the most promising is the renal sympathetic denervation, showing positive results with the second generation devices.This review summarizes current knowledge about the treatment of RH, with an emphasis on new therapeutic strategies to achieve optimal blood pressure control.…”
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Why movement disorders should be a formally acknowledged subspecialty of neurology editorial by Dirk Dressler, Ivan Milanov

“…IM: The development of medicine: Since the last century medicine has expanded tremendously in almost every aspect: in its scientific basis, in its diagnostic opportunities, in its therapeutic armamentarium and in its financial basis. …”
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Multisystem inflammatory syndrome in adults: new insights into a rare but serious complication of COVID-19 by M. Rushid, Y. Yotov, A. Kisheva

“…Despite numerous studies, clinical-laboratory and demographic analyses, there are still disagreements regarding the frequency of occurrence, pathogenesis, and diagnostic-therapeutic algorithm for these patients. The purpose of this article is to systematize the congested experience and knowledge, as well as to demonstrate their application in clinical practice.…”
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Congenital diverticulum of the left ventricle – diagnosis with echocardiography, ventriculography and magnetic resonance imaging: clinical case by Gloria Adam, Ina Tsareva, Galina Kirova, Ivo Petrov

“…Therefore, MRI is the preferred non-invasive method for evaluating the cardiac wall in detail and helps to differentiate and defi nitively diagnose congenital cardiac diverticulum, which in most cases does not require therapeutic intervention.…”
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Thrombophilia in Budd-Chiari syndrome patient by V. Dimitrova, I. Petrov, N. Zlatareva

“…In this case the multidisciplinary decisions played a major role in diagnosing and building an appropriate therapeutic strategy for systemic illnesses and conditions for which medical guidance does not yet have clear guidelines.…”
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Diagnostic algorithm in transthyretin amyloidosis with cardiomyopathy by Mariana Gospodinova, Elena Kinova, Iana Simova, Yoto Yotov, Marina Garcheva, Galina Kirova, Kamelia Genova, Albena Todorova, Stayko Sarafov, Ivailo Tournev, Mariya Tokmakova, Vasil Velchev

“…Updated knowledge about the clinical presentation, diagnostic algorithm, available and future therapeutic options for ATTR-CM are a prerequisite for an early identification, timely treatment and better prognosis of the affected patients. …”
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Chemical composition and mineral content of fresh and dried fruits of the wild rosehip (Rosa canina L.) population by Višnja Vasilj, Helena BREKALO, Danijela PETROVIĆ, Paulina ŠARAVANJA, Kristina BATINIĆ

“…The fruit is used for nutritional and pharmacological purposes, due to various chemical composition with considerable therapeutic potential. The fruit is rarely eaten fresh but has to be processed, usually dried. …”
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Chemical elements content in goat milk, whey, cheese and yogurt from an ecological and conventional farm in Slovakia by Simona Almášiová, Róbert Toman, Martina PŠENKOVÁ, Vladimír TANČIN, Šimon MIKLÁŠ, Ivona JANČO

“…Nowadays, consumption of goat milk and goat dairy products increases because of better digestion and therapeutic value. However, goat milk can contain heavy metals and trace elements as well which can harm human health. …”
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Economic evaluation and analysis of the budget effect of the measuring of fractional flow reserve in Bulgaria by G. Slavchev, N. Mileva, A. Dacheva, E. Mekov, S. Dzhambazov, D. Vassilev

“…Results: The medico-diagnostic activity related to measuring FFR in patients with multi-vessel coronary artery disease is shown to be a cost-effective therapeutic approach in Bulgaria compared to the angiography-guided PCI (ICER = 50 456 BGN/QALY) with a cost-effectiveness threshold of 51 510 BGN/QALY. …”
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