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Cytotoxicity effect of 6-mercaptopurine and 6-mercaptopurine riboside on RAW 264.7 and HIG-82 cell lines
Published 2014Get full text
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Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats
Published 2020-01-01“…Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. …”
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Cellular Uptake and Transport Mechanism of 6-Mercaptopurine Nanomedicines for Enhanced Oral Bioavailability
Published 2023-01-01Get full text
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Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature
Published 2023-09-01“…Objective: Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy. …”
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Tumor Microenvironment-Responsive 6-Mercaptopurine-Releasing Injectable Hydrogel for Colon Cancer Treatment
Published 2023-04-01Subjects: Get full text
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Double Hydroxyl Salt as Smart Biocompatible pH-Responsive Carrier for 6-Mercaptopurine
Published 2023-11-01Subjects: Get full text
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Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells
Published 2022-11-01Subjects: “…6-mercaptopurine…”
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Factitious Disorder in Crohn's Disease: Recurrent Pancytopenia Caused by Surreptitious Ingestion of 6-Mercaptopurine
Published 2015-05-01“…We present the case of a patient with Crohn's disease with recurrent pancytopenia attributed to the surreptitious ingestion of 6-mercaptopurine. In patients with possible access to immunomodulatory drugs, a high suspicion for and early identification of factitious disorder may improve patient outcomes and avoid invasive and costly diagnostic evaluations.…”
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Antiviral Potential of Azathioprine and Its Derivative 6- Mercaptopurine: A Narrative Literature Review
Published 2024-01-01“…The use of azathioprine (AZA) in human medicine dates back to research conducted in 1975 that led to the development of several drugs, including 6-mercaptopurine. In 1958, it was shown that 6-mercaptopurine decreased the production of antibodies against earlier administered antigens, raising the hypothesis of an immunomodulatory effect. …”
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Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system
Published 2013“…The release of 6-mercaptopurine from the FCMP nanocomposite was found to be sustained and governed by pseudo-second order kinetics. …”
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Inhibition of Xanthine Oxidase-Catalyzed Xanthine and 6-Mercaptopurine Oxidation by Flavonoid Aglycones and Some of Their Conjugates
Published 2020-05-01Subjects: Get full text
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Effect of maintenance therapy for childhood with acute lymphoblastic leukaemia by combination of methotrexate and 6–mercaptopurine on the liver.
Published 2005-12-01“… Seven of 30 children with acute lymphoblastic leukaemia (ALL) receiving maintenance therapy (MT) consisting of daily oral 6–mercaptopurine (6MP) and weekly methotrexate (MTX) developed both hepatocellular destruction and intrahepatic cholestasis (with abnormally elevated levels of serum aminotransferases enzymes GOT, GPT that mainly indicate liver cell destruction, and alkaline phosphatase, gammaglutamyl transferase enzymes, as well as total serum bilirubin that mainly indicate biliary tract disorder). …”
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Anti-arthritic effects of 6-mercaptopurine and its derivatives in arthritis-induced model, In vitro and In vivo
Published 2020“…In this study, four thiopurine compounds namely, 6- mercaptopurine (6-MP), 6-MP riboside, 6-thioguanine (6-TG) and 6-thioxanthine (6- TX) with diclofenac (a non-steroidal anti-inflammatory drug; NSAID) as positive control were screened for their cytotoxicity and anti-inflammatory properties by evaluating the cell cytotoxicity and the nitric oxide (NO) inhibitory activities upon activated fibroblast synoviocytes (HIG-82) and macrophage (RAW 264.7) cell lines with phorbol-12- myristate acetate (PMA) and lipopolysaccharide (LPS), respectively. …”
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Improved HPLC Quantification of 6-Mercaptopurine Metabolites in Red Blood Cells: Monitoring Data and Literature Analysis
Published 2022-10-01Subjects: Get full text
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6-Mercaptopurine-induced fever in a case of B-acute lymphoblastic leukemia: A case report
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Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.
Published 2006“…BACKGROUND: 6-mercaptopurine has been a standard component of long-term continuing treatment for childhood lymphoblastic leukaemia, whereas 6-thioguanine has been mainly used for intensification courses. …”
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Inhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin, naringenin, myricetin, ampelopsin and their conjugated metabolites
Published 2023-11-01“…In this study, we examined the impacts of luteolin, naringenin, myricetin, ampelopsin, and their sulfate/glucuronide derivatives on XO-catalyzed xanthine and 6-mercaptopurine oxidations employing in vitro enzyme incubation assays and molecular modeling studies. …”
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Exploring the Enhanced Antiproliferative Activity of Turmeric Oil and 6-Mercaptopurine in a Combined Nano-Particulate System Formulation
Published 2023-07-01Subjects: Get full text
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Profound Hypoglycemia and High Anion Gap Metabolic Acidosis in a Pediatric Leukemic Patient Receiving 6-Mercaptopurine
Published 2024-01-01Subjects: Get full text
Article