Genetically modified animals for use in biopharmacology: from research to production by Alexey V. Deykin, Olesya V. Shcheblykina, Elena E. Povetka, Polina A. Golubinskaya, Vladimir M. Pokrovsky, Liliya V. Korokina, Olesya A. Vanchenko, Elena V. Kuzubova, Konstantin S. Trunov, Viktor V. Vasyutkin, Alexandra I. Radchenko, Anton P. Danilenko, Julia V. Stepenko, Indira S. Kochkarova, Veronika S. Belyaeva, Vladimir I. Yakushev

“…Special attention is paid to genetically modified animals as bioreactors for the pharmaceutical industry of a new type. …”
Get full text

Manipulations with early mouse embryos for generation of genetically modified animals by A. N. Korablev, I. A. Serova, B. V. Skryabin

Get full text

Genetically modified animal models of hereditary diseases for testing of gene-directed therapy by Anna V. Polikarpova, Tatiana V. Egorova, Maryana V. Bardina

Get full text

Recent Progress on Genetically Modified Animal Models for Membrane Skeletal Proteins: The 4.1 and MPP Families by Nobuo Terada, Yurika Saitoh, Masaki Saito, Tomoki Yamada, Akio Kamijo, Takahiro Yoshizawa, Takeharu Sakamoto

“…In this review, we focus on our previous studies regarding genetically modified animal models, especially on 4.1G, MPP6, and MPP2, to describe their functional roles in the peripheral nervous system, the central nervous system, the testis, and bone formation. …”
Get full text

<i>piggy</i>Bac-Based Non-Viral In Vivo Gene Delivery Useful for Production of Genetically Modified Animals and Organs by Masahiro Sato, Emi Inada, Issei Saitoh, Satoshi Watanabe, Shingo Nakamura

Subjects: Get full text

The emerging role of estrogen's non-nuclear signaling in the cardiovascular disease by Hiroyuki Tokiwa, Kazutaka Ueda, Eiki Takimoto, Eiki Takimoto

Subjects: Get full text

Recent Advances in In Vivo Somatic Cell Gene Modification in Newborn Pups by Shingo Nakamura, Kazunori Morohoshi, Emi Inada, Yoko Sato, Satoshi Watanabe, Issei Saitoh, Masahiro Sato

Subjects: Get full text

Acceptance of beef obtained through genetic modification and cloning in university students and working adults in southern Chile by Berta Schnettler, Carlos Velásquez, Germán Lobos, Ligia Orellana, José Sepúlveda, Natalia Salinas-Oñate, Cristian Adasme-Berríos, Klaus G. Grunert

Subjects: Get full text

Degeneration of Bioprosthetic Heart Valves: Update 2020 by Alexander E. Kostyunin, Arseniy E. Yuzhalin, Maria A. Rezvova, Evgeniy A. Ovcharenko, Tatiana V. Glushkova, Anton G. Kutikhin

Subjects: Get full text

Progress in and Prospects of Genome Editing Tools for Human Disease Model Development and Therapeutic Applications by Hong Thi Lam Phan, Kyoungmi Kim, Ho Lee, Je Kyung Seong

“…Moreover, rapid advances in genome editing tools have accelerated the ability to produce various genetically modified animal models for studying human diseases. …”
Get full text

The New Frontier in Oxytocin Physiology: The Oxytonic Contraction by Claudia Camerino

“…Specifically, low Oxt levels are associated with obesity in human subjects and diet-induced or genetically modified animal models. The striking evidence that Oxt is linked to energy regulation is that Oxt- and oxytocin receptor (Oxtr)-deficient mice show a phenotype characterized by late onset obesity. …”
Get full text

Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling by Kenji Saito, Huxing Cui

“…Over the past few decades, genetically modified animal models have greatly increased our knowledge about the roles of estrogen receptor (ER) signaling in the brain in behavioral and physiological regulations. …”
Get full text

Novel acridone derivatives probed using DFT, including design, synthesis, characterization with anti-oxidant and anti-mitotic screening by S. Sulthanudeen, Predhanekar Mohamed Imran, M. Selvakumaran, Attar Kubaib

“…In-vitro human cancer cell lines, in-vivo tumor xenograft models and genetically modified animal models are a few of the preclinical screening techniques that were used to evaluate the anticancer efficacy of the drug. …”
Get full text

SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice by Guohua Chen, Guoli Zhou, Lidong Zhai, Xun Bao, Nivedita Tiwari, Jing Li, Emilio Mottillo, Jian Wang

“…However, the contribution of SHMT2 to hepatic 1C homeostasis and biological functions has yet to be defined in genetically modified animal models. We created a mouse strain with targeted SHMT2 knockout in hepatocytes to investigate this. …”
Get full text

Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue. by de Bono, J, Warrick, N, Bendall, J, Channon, K, Alp, N

“…Accurate measurement of NO production by endothelial nitric oxide synthase (eNOS) is critical for the investigation of vascular disease mechanisms using genetically modified animal models. Previous assays of NO production measuring the conversion of arginine to citrulline have required homogenisation of tissue and reconstitution with cofactors including NADPH and tetrahydrobiopterin. …”

Utilizing Coagulant Plants in the Development of Functional Dairy Foods and Beverages: A Mini Review by Bathmanathan, Rupbansraaj, Yasmin Amira, Che Yahya, M. M., Yusoff, Jaya Vejayan, Palliah

“…Dairy products like cheese require coagulation of milk by using enzymes such as rennet either in its original state, purified or genetically modified. Animal and microbe sourced coagulants have been facing many challenges due to increasing public awareness. …”
Get full text

The Non-Linear Path from Gene Dysfunction to Genetic Disease: Lessons from the MICPCH Mouse Model by Konark Mukherjee, Leslie E. W. LaConte, Sarika Srivastava

“…Here we discuss the implications of our observations from the pathogenesis of MICPCH as a cautionary narrative against oversimplifying molecular interpretations of data obtained from genetically modified animal models of human diseases.…”
Get full text

Physiology and Pathophysiology of Heparan Sulfate in Animal Models: Its Biosynthesis and Degradation by Ryuichi Mashima, Torayuki Okuyama, Mari Ohira

“…Mucopolysaccharidosis is a genetic disorder characterized by an accumulation of glycosaminoglycans in the body associated with neuronal, skeletal, and visceral disorders. Genetically modified animal models have significantly contributed to the understanding of the in vivo role of these enzymes. …”
Get full text

Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis by Lei Wei, Jianjian Shi

“…Studies via genetically modified animal models further established isoform-specific roles of ROCK in the pathogenesis of metabolic disorders including obesity. …”
Get full text

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases by Elsa Wilma Böhm, Nils F. Grauhan, Norbert Pfeiffer, Adrian Gericke

“…Additionally, ex vivo studies, such as myography, utilizing genetically modified animal models may provide high optical resolution for functional vascular investigations in these small vessels. …”
Get full text