Preliminary analysis on the MD-4(r) plasma-sprayed titanium acetabular component by Elmano de Araújo Loures, Leandro Furtado Simoni, Isabel Cristina Gonçalves Leite, Daniel Naya Loures, Clarice Naya Loures

“…OBJECTIVES: To evaluate the short-term performance of a type of implant manufactured in Brazil.METHODS: This study analyzed a cohort of 60 patients who underwent implantation of MD-4(r) acetabular components during primary hip arthroplasty procedures performed between January 1, 2010, and August 1, 2012. …”
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The 2017, MD = 4.0, Casamicciola Earthquake: ESI-07 Scale Evaluation and Implications for the Source Model by Rosa Nappi, Sabina Porfido, Elisa Paganini, Luigina Vezzoli, Maria Francesca Ferrario, Germana Gaudiosi, Giuliana Alessio, Alessandro Maria Michetti

“…On 21 August 2017 at 20:57 (local time) a very shallow (H = 1.2 km), moderate (Md = 4.0), earthquake hit the volcanic island of Ischia (Southern Italy), causing the death of two people. …”
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Advanced meet-in-the-middle preimage attacks : first results on full Tiger, and improved results on MD4 and SHA-2 by Guo, Jian, Ling, San, Rechberger, Christian, Wang, Huaxiong

“…Using pre-computation techniques, the time complexity for finding a new preimage or second-preimage for MD4 can now be as low as 278.4 and 269.4 MD4 computations, respectively. …”
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Directional amplification and ground motion polarization in Casamicciola area (Ischia volcanic island) after the 21 August 2017 Md 4.0 earthquake by M. Pischiutta, S. Petrosino, R. Nappi

“…In this paper, we investigated ground motion directional amplification and horizontal polarization using ambient noise measurements performed in the northern sector of Ischia Island which suffered damage (VIII EMS) during the 21 August 2017, Md 4.0 earthquake. Over 70 temporary seismic stations were installed by the INGV EMERSITO task force, whose aim is to monitor site effects after damaging earthquakes in Italy. …”
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Binding Ensembles of <i>p53</i>-MDM2 Peptide Inhibitors by Combining Bayesian Inference and Atomistic Simulations by Lijun Lang, Alberto Perez

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Within-week and between-week variability of external and internal load demands of professional male volleyball players by Ricardo Lima, Francisco Tomás González Fernandez, Joel Pereira, Lorenzo Laporta, Henrique Castro, André Rebelo, Ana Filipa Silva, Sérgio Matos, Filipe Manuel Clemente

“…Results According to the internal workload, RPE revealed significant differences between MD-4 and MD-2, MD-4 and MD1, MD-3 and MD-1, and MD-2 and MD-1 ( p < 0.05). …”
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Universal Template-Assisted, Cloning-free Method for the Generation of Small RNA-Expressing Dumbbell-Shaped DNA Vectors by Samantha Leeanne Cyrill, Avantika Ghosh, Pei She Loh, Genim Siu Xian Tan, Volker Patzel

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RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats by Terigele Bao, Lan Feng, Sungbo Cho, Hongzhen Yu, Wenjie Jin, Lili Dai, Junqing Zhang, Laxinamujila Bai, Minghai Fu, Yongsheng Chen

“…This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the mechanism behind this protective effect. …”
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Quantification of training load across two competitive seasons in elite senior and youth male soccer players from an English Premiership club by Ryland Morgans, Dave Rhodes, Jose Teixeira, Toni Modric, Sime Versic, Rafael Oliveira

“…Sprint distance was greater for first-team players at MD-3 and MD-4, while explosive distance was greater for U-18 players at MD-2. …”
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Delirium in hospitalized COVID-19 patients: Predictors and implications for patient outcome. by Vera Wilke, Mihaly Sulyok, Maria-Ioanna Stefanou, Vivien Richter, Benjamin Bender, Ulrike Ernemann, Ulf Ziemann, Nisar Malek, Katharina Kienzle, Constantin Klein, Stefanie Bunk, Siri Goepel, Annerose Mengel

“…The strongest predictors for the occurrence of delirium were blood urea nitrogen (minimal depth value (MD): 3.33), age (MD: 3.75), disease severity (as captured by WHO grading; MD: 3.93), leukocyte count (MD: 4.22), the presence of a neurodegenerative history (MD: 4.43), ferritin (MD: 4.46) and creatinine (MD: 4.59) levels.…”
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Effects of Resistance Exercise on Balance Ability: Systematic Review and Meta-Analysis of Randomized Controlled Trials by Nejc Šarabon, Žiga Kozinc

“…Moderate to large improvements following RE were seen in adults in star excursion balance test (MD: +4.09–5.17 cm; <i>p</i> = 0.001–0.020), but not for Y-balance test score (MD: +4.94%, <i>p</i> = 0.14). …”
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Efficacy and safety of different immunotherapies combined with chemotherapy as first-line therapy in patients with small cell lung cancer: a network meta-analysis by Siyao Gong, Qian Li, Xin Yu, Sha Yang

“…For OS, relative to chemotherapy (MD=-4.49; 95%CI [-7.97, -1.03]), durvalumab plus tremelimumab (MD=-4.62; 95%CI [-9.08, -0.11]), ipilimumab (MD=-4.26; 95%CI [-8.01, -0.3]) and nivolumab(MD=-5.66; 95%CI [-10.44, -1.11]) and nivolumab plus ipilimumab (MD=-4.56; 95%CI [-8.7, -0.1]), serplulimab can significantly increase the OS of SCLC patients. …”
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Arterial Perfusion of the Medial Femoral Trochlea Flap: Elucidation of Perfusion By Micro-Computed Tomographic Angiography by Andrew I. Abadeer, M.D. M.Eng., Austin Hembd, MD, Daina Brooks, MS, Bryan W. Cunningham, PhD, James P. Higgins, MD, Aviram M. Giladi, MD, MS, Valeriy Shubinets, MD

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Personality Dimensions Drive Achievement Levels of Cricket Players: A Study on the Five-Factor Model by Abhishek Kumar, Maniah Shukla, Jayashree Acharya

“…National level pace bowlers scored high on openness (national vs. district, Mean Difference (MD) = 4.25, p < 0.05; national vs. state, MD = 2.75, p < 0.05) and agreeableness (national vs. district, MD = 4.70, p < 0.05; national vs. state, MD = 3.40, p < 0.05). …”
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Effect of training day, match, and length of the microcycle on workload periodization in professional soccer players: a full-season study by José M. Oliva-Lozano, Carlos D. Gómez-Carmona, Víctor Fortes, José Pino-Ortega

“…Although MD-4 and MD-3 were the most suitable days for loading the players, the results showed that MD elicited a unique stimulus in terms of volume and intensity. …”
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Quantification of high speed actions across a competitive microcycle in professional soccer by Miguel Angel Campos-Vazquez, Asier Zubillaga, Francisco Javier Toscano-Bendala, Adam Lee Owen, Alfonso Castillo-Rodríguez

“…TRs were categorised according to days leading to the match day (MD-5, MD-4, MD-3, MD-1). The results showed significant differences between OMs and TRs across all analysed variables, except for N-HV, N-VHV, and N-SP 15–30m in the comparisons between OMs and MD-4. …”
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The efficacy and safety of Chinese herbal medicine in the treatment of painful diabetic neuropathy: A systematic review and meta-analysis by Min Song, Min Song, Baogeng Huai, Zhenpeng Shi, Wenyi Li, Yutan Xi, Zhenguo Liu, Jihang Zhang, Junyu Zhou, Yun Qiao, Deshan Liu

“…This meta-analysis found that using CHM as adjuvant treatment or as monotherapy for PDN can improve SCV of median nerve [mean difference (MD) = 3.56, 95% Confidence interval (CI) (2.19, 4.92) ], MCV of median nerve [ MD = 3.82, 95% CI (2.51, 5.12) ], SCV of common peroneal nerve [ MD = 4.16, 95% CI (1.62, 6.70) ], MCV of common peroneal nerve [ MD = 4.37, 95% CI (1.82, 6.93) ], SCV of gastrocnemius nerve [ MD = 4.95, 95% CI (3.52, 6.37) ], SCV of tibial nerve [ MD = 3.17, 95% CI (−2.64, 8.99) ], MCV of tibial nerve [MD = 6.30, 95%CI (5.00, 7.60)] and clinical effective rate [ odds ratio (OR) = 4.00, 95% CI (2.89, 5.52) ] and reduce pain score [standardized mean difference (SMD) = -2.23, 95% CI (-3.04, -1.41) ], TCM syndrome score [ MD = -4.70, 95% CI (-6.61, -2.80) ]. …”
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Comparison of Remimazolam–Flumazenil versus Propofol for Recovery from General Anesthesia: A Systematic Review and Meta-Analysis by Quantong Wu, Fuchao Xu, Jie Wang, Ming Jiang

“…Compared to propofol, the remimazolam–flumazenil combination shortened the emergence time (MD = −4.34 min, 95% CI = [−6.88, −1.81], <i>p</i> = 0.0008, low certainty), extubation time (MD = −4.26 min, 95% CI = [−6.81, −1.7], <i>p</i> = 0.0011, low certainty), and the post-anesthesia care unit (PACU) stay (MD = −4.42 min, 95% CI = [−7.45, −1.38], <i>p</i> = 0.0044, low certainty), while reducing the incidence of respiratory depression (RR = 0.2, 95% CI = [0.04, 0.89], <i>p</i> = 0.03, high certainty) after general anesthesia. …”
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Effects and safety of Ginkgo biloba on depression: a systematic review and meta-analysis by Jingya Lin, Xiaojing Sun, Lingli Yang

“…Several outcomes showed a difference, and the GKB group had better results than the control group, including the Hamilton Depression Scale (HAMD), after taking GKB for 4 weeks (MD = −2.86, 95%CI [−4.27, −1.46], p &lt; 0.01), 6 weeks (mean difference (MD) = −3.36, 95%CI [−4.05, −2.67], p &lt; 0.01), and 8 weeks (MD = −4.58, 95% CI [−6.11, −3.05], p &lt; 0.01), modified Barthel index (MBI) (MD = 14.86, 95%CI [12.07, 17.64], p &lt; 0.01), modified Edinburgh-Scandinavian stroke scale (MESSS) (MD = −4.57, 95%CI [−6.34, −2.79], p &lt; 0.01), brain-derived neurotrophic factor (BDNF) (MD = 16.35, 95%CI [7.34, 25.36], p &lt; 0.01), 5-hydroxytryptamine (5-HT) (MD = 4.57, 95%CI [3.08, 6.05], p &lt; 0.01), and clinical efficacy (risk ratio, RR = 1.24, 95%CI [1.17, 1.32], p &lt; 0.01). …”
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Xinmailong injection on left ventricular remodeling and inflammatory mediators in patients with CHF: a systematic review and meta-analysis by Xu Han, Xi Chen, Yanling Liu, Jie Yang, Wuzhi Nie, Mingjiu Yang, Xinglang Mou

“…Furthermore, statistical analysis, sensitivity analysis, and publication bias assessment were conducted using Stata 17.0 software.Result:Compared with conventional treatment (CT), the combination therapy of XMLI and CT significantly improved LVR and reduced inflammatory mediators, mainly manifested by an increase in LVEF (MD = 6.40, 95% CI: 5.25 to 7.55, p = 0.000), a decrease in LVEDD (MD = −4.63, 95% CI: −5.69 to −3.57, p = 0.000) and LVESD (MD = −4.00, 95% CI: −5.50 to −2.50, p = 0.000), as well as a decrease in TNF-α (MD = −7.93, 95% CI: −9.86 to −6.00, p = 0.000), IL-6 (MD = −5.25, 95% CI: −6.59 to −3.92, p = 0.000), IL-18 (MD = −36.07, 95% CI: −46.76 to −25.38, p = 0.000), CRP (MD = −4.41, 95% CI: −6.40 to −2.42, p = 0.000), hs-CRP (MD = −4.90, 95% CI: −5.71 to −4.08, p = 0.000), and an increase in IL-10 (MD = 20.19, 95% CI: 10.42 to 29.97, p = 0.000). …”
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