Halofantrine in the treatment of malaria. by Horton, J

Halofantrine in the treatment of multidrug resistant malaria by Philip Davis Marsden

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Cardiac effects of antimalarial treatment with halofantrine. by Nosten, F, ter Kuile, F, Luxemburger, C, Woodrow, C, Kyle, D, Chongsuphajaisiddhi, T, White, N

“…More than 60% of the effect occurred with three doses of halofantrine (24 mg/kg). The arrhythmogenic potential of halofantrine should now be investigated.…”

The treatment of falciparum malaria in children with halofantrine suspension by R. J. Horton, S. N. Parr, L. C. Bokor

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Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. by Krishna, S, ter Kuile, F, Supanaranond, W, Pukrittayakamee, S, Teja-Isavadharm, P, Kyle, D, White, N

“…1 The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12 adults with acute uncomplicated falciparum malaria and nine adults who attended in convalescence. 2 Intravenous halofantrine (1 mg kg(-1) infused in 1 h) was given every 8 h for a total of three doses in the acute study. …”

Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography. by Ter Kuile, F, Teja-Isavatharm, P, Edstein, MD, Keeratithakul, D, Dolan, G, Nosten, F, Phaipun, L, Webster, H, White, N

“…Whole blood mefloquine, halofantrine, and desbutyl-halofantrine concentrations were measured by high-performance liquid chromatography in capillary blood, venous blood, and venous plasma samples from patients along the Thai/Burmese border with falciparum malaria who were treated with either mefloquine (25 mg/kg) or halofantrine (24 mg/kg or 72 mg/kg). …”

Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats by BC Didia, EB Dede, AO Obianime

“…The toxicity of halofantrine hydrochloride to the pancreas of wistar rats (Rattus norvegicus) was studied using twenty five male wistar rats divided into five groups of five rats per group. …”
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Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria. by ter Kuile, F, Dolan, G, Nosten, F, Edstein, MD, Luxemburger, C, Phaipun, L, Chongsuphajaisiddhi, T, Webster, H, White, N

“…We have investigated the relative efficacy of halofantrine and mefloquine in two paired randomised trials on the Thai-Burmese border, a multidrug-resistant area. …”

Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine. by Baird, J, Basri, H, Subianto, B, Fryauff, D, McElroy, P, Leksana, B, Richie, T, Masbar, S, Wignall, F, Hoffman, S

“…Thus, chloroquine plus primaquine in combination and halofantrine alone are effective therapies for chloroquine-resistant P. vivax.…”

Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia. by Fryauff, D, Baird, J, Basri, H, Wiady, I, Purnomo, Bangs, M, Subianto, B, Harjosuwarno, S, Tjitra, E, Richie, T, Hoffman, S

“…The combination of halofantrine and primaquine therapies was calculated as a regimen for achieving radical curve of falciparum or vivax malaria in Irian Jaya, Indonesia, and compared with combined chloroquine and primaquine therapies. …”

Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria. by Watkins, WM, Winstanley, P, Mberu, E, Kokwaro, G, Murphy, SA, Newton, C, Mwangi, I, Forster, D, Marsh, K

“…Kenyan children with uncomplicated malaria given oral halofantrine (HF; non-micronised suspension; 8 mg base kg-1 body weight 6 hourly for three doses) showed wide variation in the disposition of HF and desbutylhalofantrine (HFm). 2. …”

Preliminary Study on the Effect of Halofantrine Hydrochloride on the Testes of Mature Wistar Rats by B C Didia, P S Gbigbi, D Dapper, P. C VOFOJEKWU, I S EZENWAKA, W O ALEGBELEYE

“…Halofantrine hydrochloride is a phenantrine methanol antimalarial, which is schizonticidal with a high degree of activity against the asexual erythrocytic stage of malaria parasites. …”
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Other 4-methanolquinolines, amyl alcohols and phentathrenes: Mefloquine, lumefantrine and halofantrine by Nosten, F, Phillips-Howard, P, ter Kuile, F

“…This chapter describes mefloquine, pyronaridine, halofantrine, piperaquine and lumefantrine under the broader title of the 4-methanolquinolines, amyl alcohols and phentathrenes. …”

Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria by Klein, K, Aarons, L, Ter Kuile, F, Nosten, F, White, N, Edstein, MD, Teja-Isavadharm, P

“…Aims To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. …”

Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria. by Klein, K, Aarons, L, Ter Kuile, F, Nosten, F, White, N, Edstein, MD, Teja-Isavadharm, P

“…AIMS: To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. …”

Short report: in vivo sensitivity of Plasmodium falciparum to halofantrine in southern central Vietnam. by Doan, H, Taylor, W, Nguyen, D, Tran, T, Fryauff, D, Susanti, I, Gómez-Saladín, E, Le, D, Baird, J

“…We assessed the in vivo sensitivity of P. falciparum to halofantrine in two villages in the southern part of central Vietnam. …”

Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base by Danis Martin, Dodoo Alex NO, Touze Jean, Imbert Patrick, Bouchaud Olivier, Legros Fabrice

“…<p>Abstract</p> <p>Background</p> <p>Halofantrine (HF) was considered an effective and safe treatment for multi-drug resistant falciparum malaria until 1993, when the first case of drug-associated death was reported. …”
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Halofantrine Hydrochloride Acts as an Antioxidant Ability Inhibitor That Enhances Oxidative Stress Damage to <i>Candida albicans</i> by Juan Xiong, Li Wang, Zhe Feng, Sijin Hang, Jinhua Yu, Yanru Feng, Hui Lu, Yuanying Jiang

Subjects: “…halofantrine hydrochloride…”
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Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in southern, central Vietnam using an extended 28-day in vivo test and polymerase chain reaction genotyping. by Taylor, W, Doan, H, Nguyen, D, Tran, T, Fryauff, D, Gómez-Saladín, E, Kain, K, Le, D, Baird, J

“…We assessed the drug sensitivity of P. vivax to chloroquine or halofantrine in two villages in southern, central Vietnam. …”

Antimalarial drug susceptibility testing of Plasmodium falciparum in Brazil using a radioisotope method by Crispim Cerutti Junior, Christiane Marques, Filomena EC de Alencar, Rui Rafael Durlacher, Anna Alween, Aluísio AC Segurado, Lorrin W Pang, Mariano G Zalis

“…Thirty-one samples were tested for chloroquine, mefloquine, halofantrine, quinine, arteether and atovaquone. Resistance was evidenced in 96.6% (29/30) of the samples tested for chloroquine, 3.3% (1/30) for quinine, none (0/30) for mefloquine and none for halofantrine (0/30). …”
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