New perspectives for use of gamma-glutamyltranspeptidase in clinical enzymes tests by L. A. Alexandrova

“…Gamma-glutamyltranspeptidase (GGTP), isolated from a variety of sources from microorganisms to mammals, including human blood and organs, has been studied sufficiently detailed, which allowed to take a fresh look at the role of this enzyme in cellular metabolism, the pathogenesis of several diseases and its application in clinical medicine. …”
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EFFECTIVENESS OF MELDONIUMIN IN CHRONIC HEART FAILURE PATIENTS by G. N. Gorokhovskaya, V. L. Yoon, A. S. Skotnikov, A. I. Martynov, E. Yu. Maychuk

“…In treatment notes medications that possess cytoprotective effects that affect cellular metabolism, ionic homeostasis, structure and function of membranes. …”
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Association of prooxidant-antioxidant disorders with the development of morphofunctional disorders in rats with subtotal cerebral ischemia by N. E. Maksimovich, E. I. Bon, E. I. Troyan, N. A. Valko

“…Brain ischemia has been followed by oxidative stress in brain tissue. The cellular metabolism has been disturbed under the oxidative stress that leads to a water-electrolyte imbalance, manifested by deformation of neuron bodies, wrinkling, and swelling. …”
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HYPERAMMONIUM IN PATIENTS WITH PRECIRRHOSIS STAGE: CLINICAL REALITY? by L. Yu. Ilchenko, I. G. Nikitin

“…Ammonia induces the formation of oxygen active forms, reduces the activity of endothelial NO synthase, dose-dependently decreases the cellular metabolism and proliferation of stellate cells, and promotes fibrogenesis, disturbance of intrahepatic hemodynamics and, accordingly, the formation of portal hypertension. …”
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Therapy experience in alopecia after COVID-19 by O. A. Katkhanova, M. V. Golubchenko

“…The patients received a complex drug for the treatment of alopecia, 1 tablet three times a day for 2 months, and a peptide lotion for cutaneous use with active ingredients, which activate cellular metabolism in hair follicles, encourage the hair follicles to switch to the active growth phase. …”
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Biochemical blood values of ewes in the first month of lactation and their relation to milk productivity by Ya. A. Zharikov

“…Glucose and alkaline phosphatase indicate an increase in the intensity of cellular metabolism.…”
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Overexpression of p63 Protein in Patients with Seborrheic Keratosis in the Setting of Carbohydrate Metabolism Disorders by A. К. Alexandrova, V. A. Smolyannikova

“…P63 overexpression in seborrheic keratosis correlates with the presence of chronic hyperglycemia in patients. Disruption of cellular metabolism leads to changes in the balance between p63 isoforms and plays an important role in the pathogenesis of seborrheic keratosis.…”
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Effect of β-alanine on humoral immune response in low-dose allergy model by D. B. Chudakov, O. D. Kotsareva, D. S. Tsaregorotseva, E. I. Kashirina, G. V. Fattakhova

“…The effect of β-alanine on humoral immune response could be linked to its non-specific action, e.g., due to its ability to induce oxidative stress through blocking taurine transporter, or due to its ability to stimulate cellular metabolism.…”
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A comparative analysis of miRNA expression in human lung epithelial cells during infection with influenza virus and RNAse treatment by Irina A. Baichurina, M. I. Markelova, R. Shah Mahmud

“…We hypothesize that intact viruses or their intracellular components are able to alter cellular metabolism by skewing it to decreased resistance to carcinogenesis processes.…”
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Pleiotropic effects of PPAR-α – from benchside to bedside by I. V. Shirinsky, V. S. Shirinsky

“…We discuss structure of natural and synthetic ligands of PPARa, molecular and cellular mechanisms of PPARa regulation of lipid and carbohydrate cellular metabolism. PPARa activity in hepatocytes results in decrease of intracellular concentrations of lipid acids. …”
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Congenital cerebral palsy: genetic cause and nosological integrity by P. I. Sokolov, N. V. Chebanenko, V. P. Zykov, I. V. Kanivets, A. G. Prityko, P. A. Romanov

“…Based on the study of data from numerous studies, the authors draw the following conclusions:1) the pathogenesis of the phenotype of CP includes a large number of genes that determine violations of cellular metabolism, neuroontogenesis, brain resistance to hypoxia, etc;2) genes whose abnormalities form a syndromic pathology are involved in the pathogenesis of CP;3) the multidirectionality and breadth of the effects of the gene pool with the outcome in a syndrome-specific distinctive picture of the CP allows us to propose the concept of a neurotropic genome;4) the mechanisms of gene involvement can vary from aberrations to epigenetic imbalances;5) different groups of genes can differentially influence the formation of individual syndromes in the phenotype of CP;6) there are data indicating a genetic determinism of the tendency to contracture, pharmacoreactivity to drugs that reduce muscle tone, reactivity to habilitation effects;7) genomic-epigenomic interactions normally ensure the body’s adaptation to environmental conditions, and with pathology, they increase the likelihood of regulatory breakdowns that lead to the formation of a CP phenotype;8) the exclusion from the diagnosis of CP of genetically determined cases of phenotype development is incorrect.The authors present two anthropogenic reasons for the increase in the frequency of occurrence of de novo identified gene abnormalities:1) anthropogenic impact on the environment, increasing the number of anomalies of the genome de novo; 2) iatrogenic effects of technologies for preserving life, vitality and reproductive ability of carriers of genomic anomalies. …”
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FUNCTIONS OF THE mTOR SIGNALING PATHWAY IN NORMAL ARTICULAR CARTILAGE CHONDROCYTES AND IN OSTEOARTHRITIS by E. V. Chetina, N. G. Kashevarova, E. P. Sharapova

“…One of the major cellular metabolic regulators is the protein mTOR (mechanistic target of rapamycin) that controls cell growth, proliferation, protein biosynthesis and integrates extracellular signals from growth factors and hormones with amino acid availability and intracellular energy status. …”
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EXPERIENCE OF PERFUSION RECELLULARIZATION OF BIOLOGICAL LUNG SCAFFOLD IN RATS by E. V. Kuevda, E. A. Gubareva, A. S. Sotnichenko, I. S. Gumenyuk, I. V. Gilevich, I. S. Polyakov, V. A. Porhanov, S. N. Alekseenko, P. Macchiarini

“…Recellularization was followed by assessment of the cellular metabolic activity by colorimetric method; cell viability was analyzed by calcein and ethidium homodimer staining. …”
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Analysis of Gene Expression Omnibus high-throughput sequencing data for the determination of microribonucleic acids in the blood plasma of patients with glioblastomas by A. A. Pushkin, D. Yu. Gvaldin, N. N. Timoshkina, E. E. Rostorguev, L. Yu. Vladimirova, E. A. Dzenkova

“…For significant miRNAs, information was obtained on experimentally confirmed target genes, a gene ontology demonstrating their participation in enzyme binding, participation in the regulation of primary cellular metabolic processes, and the development of glioblastomas and cancer in general.Conclusion. …”
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DEPENDENCE OF NEUTROPHIL RESPIRATORY BURST ON THEIR METABOLIC STATE IN THE PATIENTS WITH ACUTE DESTRUCTIVE PANCREATITIS OF DIFFERENT SEVERITY by A. A. Savchenko, A. G. Borisov, D. E. Zdzitovetskiy, A. Yu. Medvedev, I. I. Gvozdev

“…The changes in cellular metabolic activity in the patients with moderate ADP led to disturbances of their regulatory effect upon the state of neutrophil respiratory burst. …”
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